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Antibody Engineering Jobs (NOW HIRING)

Ohio State University

The Center will leverage cutting-edge technologies to develop monoclonal antibodies, bispecific antibodies (bsAb), antibody-drug conjugates (ADCs), antibody engineering, and other antibody-based ...

Vistera Inc

Senior Scientist, Research

Waltham, MA

$107K - $136K/yr

Design and execute experiments involving immunization strategies, antibody library generation, antibody engineering, and in vitro/in vivo characterization of antibody-antigen interactions. * Provide ...

Ohio State University

Applicants must have a national and international reputation in antibody discovery and engineering, and significant independent research experience with both historical and current federal funding of ...

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How much do antibody engineering jobs pay per hour?

As of Jun 15, 2026, the average hourly pay for antibody engineering in the United States is $33.06, according to ZipRecruiter salary data. Most workers in this role earn between $26.44 and $38.22 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Antibody Engineering position, and why are they important?

To thrive in Antibody Engineering, you need a strong background in molecular biology, biochemistry, and protein engineering, typically supported by an advanced degree in a related field. Experience with molecular cloning techniques, high-throughput screening platforms, and data analysis software such as Python or R is highly valuable. Strong problem-solving abilities, attention to detail, and effective teamwork skills set top candidates apart. These competencies enable successful design and optimization of antibodies, critical for therapeutic and diagnostic applications.

What does a typical day look like for someone working in Antibody Engineering?

A typical day in Antibody Engineering involves designing and generating antibody variants in the lab, analyzing experimental data, and collaborating with multidisciplinary teams such as bioinformatics, cell biology, and process development. You may participate in regular meetings to discuss project progress, troubleshoot experiments, and optimize methodologies. Much of the work is hands-on and fast-paced, with deadlines tied to ongoing research projects or product development timelines. This role offers a dynamic environment where continuous learning and innovation are highly encouraged.

What is an Antibody Engineering job?

An Antibody Engineering job involves designing, modifying, and optimizing antibodies for therapeutic, diagnostic, or research applications. Professionals in this field use techniques such as protein engineering, phage display, and computational modeling to enhance antibody specificity, stability, and efficacy. They work in biotechnology, pharmaceutical, or academic settings to develop novel treatments for diseases like cancer, autoimmune disorders, and infectious diseases. This role requires expertise in molecular biology, immunology, and bioinformatics.

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Antibody Engineering jobs near you
Infographic showing various Antibody Engineering job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $68,760 per year, or $33.1 per hour.
Director/Senior Director, Antibody Discovery

Director/Senior Director, Antibody Discovery

BigHat Biosciences

San Mateo, CA

$230K - $270K/yr

Other

Medical, Dental, Vision, Retirement

Posted 3 hours ago

Job description

The Role: BigHat is seeking an exceptional and highly experienced individual for a position as Director/Senior Director of Antibody Discovery. This individual will lead the company's antibody discovery and display function. They will be responsible for conceiving of and leading multi-year team and technology strategy as well as managing routine operational execution for identification and maturation of high-quality antibodies across antigen types for both BigHat and BigHat-partnered therapeutic research programs.
  • Lead BigHat's antibody discovery and display functions, setting the scientific, technical, and strategic direction 
  • Oversee the routine execution of display-based selection campaigns to enhance and diversify affinity, developability, and function across diverse antibody formats and antigen types in support of BigHat and BigHat-partnered therapeutic programs
  • Manage and mentor a team of scientists responsible for antibody library design, generation, screening, selection, and early optimization
  • Shape and expand BigHat's antibody discovery technologies and capabilities, including new display and selection methods, library design strategies, and technical approaches that leverage and enhance the company's integrated experimental and computational platform
  • Provide scientific leadership across discovery and early optimization efforts, ensuring antibodies emerging from selections possess strong functional and developability characteristics
  • Work closely with leaders in Protein Sciences, Data Science/Machine Learning, Engineering, and Platform groups to ensure seamless progression from discovery through characterization and optimization
  • Collaborate with biology and therapeutic research leads to ensure display outputs align with and advance program objectives
  • Foster a collaborative and high-performance culture within the discovery organization
  • Ph.D. in molecular biology, biochemistry, protein engineering, or related discipline with 12+ years of experience in antibody discovery and engineering within academia, biotechnology, or pharmaceutical industries
  • 8+ years of managerial experience leading scientific teams
  • Strong expertise with protein display systems such as yeast, phage, mammalian, or mRNA display
  • Demonstrated experience with antibody library design, construction, screening, and selection analysis
  • Deep understanding of antibody structure-function relationships and mechanisms of antigen recognition
  • Experience integrating antibody discovery workflows with downstream characterization and developability assessment, including functional screening and biophysical evaluation of antibody candidates
  • Familiarity with computational or ML-enabled approaches to protein design and optimization
  • Experience advancing biologics from early discovery through lead optimization stages
  • Knowledge of diverse antibody modalities including multispecific antibodies, antibody fragments, and other advanced formats
  • Strong leadership skills with experience building and mentoring scientific teams
  • Strategic thinker capable of aligning discovery activities with broader company goals
  • Excellent communication and cross-functional collaboration skills
  • Self-motivated and comfortable working in a fast-paced startup environment
  • Must be willing to work onsite 5 days per week
The salary estimated for this position is $230,000 - $270,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match 
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave

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