60 Regeneron Engineers Jobs Hiring Near You

Location: Cambridge, MA (primary site)

The Head of Regeneron Cell Medicines (RCM) sets the vision, strategy, and execution for Regeneron's cell medicines portfolio and technology platform. Scope includes ex vivo and in vivo CAR T programs and enabling technologies for delivery, including chemo-free conditioning. This leader oversees cross-functional initiatives from discovery through early clinical development, builds and mentors high-performing teams, and partners across the enterprise and with external collaborators to deliver transformative cell-based therapies. Based in Cambridge, MA, this role serves as the site's senior scientific executive and advances the RCM portfolio in alignment with Regeneron's broader scientific vision.

In This Role, You Will:

• Define and drive the long-term scientific vision and portfolio strategy for ex vivo and in vivo cell medicines, aligned to enterprise priorities.
• Prioritize programs and platform investments using data-driven governance, scenario planning, and risk/benefit frameworks.
• Champion innovation in cell engineering, in vivo delivery (e.g., LNPs, viral vectors), and manufacturing to create differentiated therapies.
• Establish and evolve the CAR T strategy, including target selection, tissue/cell targeting, potency enhancement, and combinations with antibody-based approaches.

• Lead matrixed teams to deliver milestones from target validation to IND, Phase I manufacturing, and early clinical readouts.
• Guide technical problem solving across modalities, including CAR T design, delivery optimization, biodistribution/PK, on/off-target assessment, and safety risk mitigation.
• Integrate enabling platforms where justified (e.g., CAR Ts, antibody-based approaches such as CPIs and bispecifics, encoded potency enhancements, ARMoR'ing strategies).
• Drive benign conditioning initiatives that enable chemo-free delivery of cell-based medicines (including T cells and hematopoietic stem cells).

• Build, mentor, and retain a diverse, high-performing organization of senior scientific leaders and functional experts.
• Foster a culture of scientific excellence, accountability, collaboration, and inclusion across sites and functions.
• Implement succession planning, talent development, and performance management.

• Partner closely with Research, Preclinical Development, Clinical, Regulatory, Quality, CMC, Manufacturing, BD, and Finance.
• Serve as the senior scientific leader for the Cambridge site; maintain strong operating rhythms with Seattle and Tarrytown leadership.
• Coordinate with vector/delivery, immunology, and translational biomarker teams to accelerate RCM programs to clinical evaluation.

• Identify and evaluate external opportunities (academia, biotech, consortia, platforms) to accelerate the pipeline and capabilities.
• Negotiate and govern collaborations to clear, value-creating outcomes.

• Own budgets, headcount planning, and resource allocation across programs and platform functions.
• Ensure adherence to biosafety, ethical guidelines, and regulatory standards (e.g., IND enabling, GxP interfaces), including nonclinical programs specific to ex vivo and in vivo cell therapy (biodistribution, preclinical safety).
• Drive reproducibility, data integrity, and robust decision records.

• Provide clear, concise updates to executive leadership and governance bodies on strategy, progress, risks, and mitigation plans.
• Represent Regeneron Cell Medicines at internal and external forums, scientific conferences, and with partners.

What You Need to Succeed:

• Advanced degree (PhD, MD, or MD/PhD) in cell biology, immunology, bioengineering, or related discipline.
• 20+ years of biopharmaceutical R&D experience with a substantial focus on cell-based therapies; track record advancing programs from discovery to IND and early clinical.
• Demonstrated leadership of multidisciplinary, multisite teams and senior people leaders in a fast-paced environment.
• Deep expertise across key domains:
• Cell engineering (e.g., CAR design, viral vectors), potency/identity assays, process and analytical development, and translational biology.
• In vivo gene delivery for in vivo CAR T, including viral and non-viral modalities (e.g., LVV, LNPs), tissue/cell targeting strategies, biodistribution/PK, on/off-target risk assessment, and immunogenicity management.
• CMC considerations for in vivo modalities (vector design, release testing, stability) versus ex vivo products.
• Familiarity with regulatory pathways for cell and gene therapies (e.g., FDA/EMA guidance, IND preparation, RMAT considerations), including in vivo gene therapy nonclinical packages (biodistribution, toxicology, shedding).
• Strong portfolio management, resource planning, and financial acumen.
• Exceptional communication, influence, and stakeholder management; effective in executive forums and cross-functional decision making.
• Commitment to building an inclusive culture and developing talent.

• Strategic vision and critical thinking that drive high-quality decisions.
• Scientific rigor and an innovation mindset, balanced by a patient-centric bias for action.
• Talent development and coaching.
• Cross-functional collaboration and influence beyond direct reporting lines.
• Results orientation and accountability.
• Change leadership and resilience.

• On-site presence 4+ days per week in Cambridge, MA; regular travel to Tarrytown, NY and Seattle, WA.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on?site. Please speak with your recruiter and hiring manager for more information about on?site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.