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Guardant Health
Guardant Health

54 Guardant Health Hardware Design Engineer Jobs Hiring Near You

Guardant Health

Staff Scientist-LCMS

Palo Alto, CA · On-site

$150K - $206K/yr

Company Description Guardant Health is a leading precision oncology company focused on guarding ... Design and refineLC gradients to achieve optimal separation, sensitivity, and throughput * Optimize ...

Guardant Health

Staff Business Analyst

Palo Alto, CA

$72K - $96K/yr

Company Description Guardant Health is a leading precision oncology company focused on guarding ... Operate as part of the product and engineering team, owning the problem space from early discovery ...

Guardant Health

Staff Business Analyst

Palo Alto, CA · On-site

$72K - $96K/yr

Company Description Guardant Health is a leading precision oncology company focused on guarding ... Operate as part of the product and engineering team, owning the problem space from early discovery ...

Guardant Health

Manager, Business Systems

Palo Alto, CA · On-site

$150.80 - $207.35/hr

Guardant Health is a leading precision oncology company focused on guarding wellness and giving ... Lead analysis, design, implementation, and support of the Oracle Fusion Financial Cloud production ...

Guardant Health

Manager, Business Systems

Palo Alto, CA · On-site

Company Description Guardant Health is a leading precision oncology company focused on guarding ... Lead analysis, design, implementation, and support of the Oracle Fusion Financial Cloud production ...

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Guardant Health Jobs Information

What is it like to work at Guardant Health?

Guardant Health is a company that values innovation, collaboration, and a patient-centric approach, fostering a culture of teamwork and open communication among its employees.

The company's structure is organized into multidisciplinary teams that work together to develop and commercialize liquid biopsy technologies, with a focus on improving cancer diagnosis and treatment. The work environment is dynamic and fast-paced, with opportunities for professional growth and development in a rapidly evolving field.

Working at Guardant Health may appeal to individuals who are passionate about advancing cancer care and are looking for a challenging and rewarding career in a cutting-edge biotechnology company with a strong commitment to innovation and patient outcomes.

What makes Guardant Health an attractive place to work?

Guardant Health is a leading precision oncology company that has established itself as a pioneer in the field of liquid biopsy and cancer genomics. The company's workplace culture values innovation, collaboration, and a commitment to making a meaningful impact in the fight against cancer, with a focus on fostering a dynamic and inclusive environment that encourages creativity and growth. By joining Guardant Health, individuals can contribute to groundbreaking research and development, expand their skills and expertise, and be part of a team that is shaping the future of cancer care.

Does Guardant Health pay people when they’re sick?

Yes. Most people get paid when they’re sick.
83% of people say they would get paid if they were sick but scheduled to work.
Based on data from 6 people who took the Breakroom Quiz between May 2025 and July 2026.

At Guardant Health, are sick days and vacation days separate paid time off?

Sick days and vacation days are separate paid time off.
80% of people say they don’t have to use vacation days when they’re out sick.
Based on data from 5 people who took the Breakroom Quiz between June 2025 and July 2026.

Is the health insurance from Guardant Health affordable enough for their workers?

Most people say the health insurance costs are okay.
100% of people say the health insurance costs are okay
Based on data from 5 people who took the Breakroom Quiz between May 2025 and July 2026.

Do people get paid time off at Guardant Health?

Most people get paid time off work.
100% of people say they get paid time off.
Based on data from 5 people who took the Breakroom Quiz between June 2025 and July 2026.

How easy is it to get time off at Guardant Health?

Most people find it easy to get time off.
100% of people report it’s easy to get time off.
Based on data from 5 people who took the Breakroom Quiz between May 2025 and July 2026.

How easy is it to take sick days at Guardant Health?

Most people find it easy to take sick days.
100% of people report that it’s easy to take time off if they are sick.
Based on data from 5 people who took the Breakroom Quiz between May 2025 and July 2026.

Do people at Guardant Health feel treated with respect by their managers?

Most people feel treated with respect by their managers.
100% of people say they’re treated with respect by their managers.
Based on data from 6 people who took the Breakroom Quiz between May 2025 and July 2026.

Do people at Guardant Health get to take their breaks without interruption?

Most people get breaks without interruption.
100% of people report that they get to take their breaks without interruption.
Based on data from 5 people who took the Breakroom Quiz between May 2025 and July 2026.

Is it stressful to work at Guardant Health?

Some people feel stressed here.
67% of people say they often feel stressed at work.
Based on data from 6 people who took the Breakroom Quiz between May 2025 and July 2026.

Do people at Guardant Health enjoy their jobs?

Most people enjoy their job.
100% of people report they enjoy their job.
Based on data from 5 people who took the Breakroom Quiz between May 2025 and December 2025.

Do people at Guardant Health recommend working with their team?

Most people recommend working with their team.
100% of people report that they would recommend working with their immediate team to a friend.
Based on data from 6 people who took the Breakroom Quiz between May 2025 and July 2026.

Do people get support to advance at Guardant Health?

Most people are given support to advance their career here.
In the last year, 100% of people report being given support to advance their career here.
Based on data from 6 people who took the Breakroom Quiz between May 2025 and July 2026.

Do workers feel well informed about how Guardant Health is doing?

Most people feel well informed about how the company is doing.
80% of people feel that they are kept well informed about how the company is doing as a whole.
Based on data from 5 people who took the Breakroom Quiz between May 2025 and July 2026.

What other companies are hiring for Hardware Design Engineer jobs?

What are the most popular jobs at Guardant Health?

What are the most popular categories at Guardant Health?

Infographic showing various Hardware Design Engineer job openings at Guardant Health in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 58% Physical, 1% Hybrid, and 41% Remote job distribution.

Staff Scientist-LCMS

Guardant Health

Palo Alto, CA • On-site

$150K - $206K/yr

Full-time

Re-posted 28 days ago

Guardant Health rating

9.4

Company rating: 9.4 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

3rd of 120 rated laboratories

Job description

Company Description
Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant® is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook.
Key Responsibilities
  • Develop and optimize targeted LC-MS methods (MRM/PRM) for small molecules, lipids, and/or peptides
  • Design and refineLC gradients to achieve optimal separation, sensitivity, and throughput
  • Optimize MS/MS parameters (collision energy, resolution, scan speed, dwell time)
  • Establish and implement quantification strategies (internal standards, calibration curves, QC normalization)
  • Evaluate assay performance: precision, accuracy, linearity, dynamic range, LLOQ/ULOQ
  • Assess and mitigate matrix effects and ion suppression
  • Operate and troubleshoothigh-resolution MS systems (e.g., Orbitrap) and/or triple quadrupole platforms
  • Support method transfer across instruments and sites
  • Integrate workflows with automated sample preparation systems
  • Document methods and support CLIA/FDA-aligned validation and SOP development

Qualifications
  • PhD (or MSc with strong experience) in Analytical Chemistry, Biochemistry, or related field
  • 5+ years of experience in targeted LC-MS method development
  • Hands-on expertise withPRM (HRMS)
  • Strong understanding of quantitative LC-MS workflows in biological matrices

Preferred:
  • Experience in lipidomics, proteomics, or clinical assays
  • Familiarity with regulated environments (CLIA/FDA/ISO)
  • Experience with high-throughput or automated workflows
  • Experience with biological specimens.
  • Experience with high resolution mass spectrometry

AI & Digital Fluency
  • Demonstrate curiosity, sound judgment, and the ability to critically evaluate and responsibly leverage AI-enabled tools in accordance with company policies, ethical standards, and regulatory requirements to improve the efficiency, effectiveness, and quality of work.

Hybrid Work Model:This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays, Tuesdays, and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant, our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.
The annualized base salary ranges for the primary location and any additional locations are listed below. This range does not include benefits or, if applicable, bonus, commission, or equity. Each candidate's compensation offer will be based on multiple factors including, but not limited to, geography, experience, education, job-related skills, job duties, and business need.Primary Location: Palo Alto, CAPrimary Location Base Pay Range: $150,100 - $206,400Other US Location(s) Base Pay Range: $127,585 - $175,440If the role is performed in Colorado, the pay range for this job is: $135,090 - $185,760
Employee may be required to lift routine office supplies and use office equipment. Majority of the work is performed in a desk/office environment; however, there may be exposure to high noise levels, fumes, and biohazard material in the laboratory environment. Ability to sit for extended periods of time.
Guardant Health is committed to providing reasonable accommodations in our hiring processes for candidates with disabilities, long-term conditions, mental health conditions, or sincerely held religious beliefs. If you need support, please reach out to Peopleteam@guardanthealth.com
A background screening including criminal history is required for this role. GH will consider qualified applicants with criminal arrest or conviction histories in a manner consistent with applicable law including but not limited to the LA County Fair Chance Policies and the Fair Chance Act (Gov. Code Section 12952).
Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
All your information will be kept confidential according to EEO guidelines.
To learn more about the information collected when you apply for a position at Guardant Health, Inc. and how it is used, please review our Privacy Notice for Job Applicants.
Please visit our career page at: http://www.guardanthealth.com/jobs/

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