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Oligonucleotide Jobs (NOW HIRING)

Dyne Tx

$159 - $200/hr

Role Summary The Principal Scientist of Oligonucleotide Development will lead the chemical synthesis strategy for PMO and modified ASO payload molecules, managing execution both internally and across ...

Eli Lilly and Company

Advisor - RNA Chemistry

Indianapolis, IN · On-site

$23.25 - $30.50/hr

The Lilly Genetic Medicine group is at the forefront of oligonucleotide medicinal chemistry research and synthetic chemistry innovation, with the goal of establishing Lilly as a leader in genetic ...

LGC Group

Principal Chemist

Petaluma, CA · On-site

Principal Oligonucleotide Chemist Company: LGC Biosearch Technologies Location: 2100 South McDowell, Petaluma, CA 94952 Type: Fulltime Company Overview LGC Biosearch Technologies operates across ...

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How much do oligonucleotide jobs pay per hour?

As of Sep 4, 2026, the average hourly pay for oligonucleotide in the United States is $23.35, according to ZipRecruiter salary data. Most workers in this role earn between $18.27 and $26.44 per hour, depending on experience, location, and employer.

What is an oligonucleotide?

An Oligonucleotide job typically involves the synthesis, purification, analysis, and quality control of short DNA or RNA sequences used in research, diagnostics, and therapeutics. Professionals in this role may work in biotechnology, pharmaceutical, or academic settings, ensuring the accurate production of oligonucleotides for applications such as PCR, gene editing, and drug development. Responsibilities often include operating automated synthesizers, troubleshooting synthesis issues, and maintaining laboratory protocols. Strong knowledge of molecular biology, chemistry, and instrumentation is essential.

What are the typical responsibilities of an oligonucleotide specialist, and how does the role collaborate with others in the lab?

Oligonucleotide Specialists are primarily responsible for synthesizing, purifying, and characterizing short strands of DNA or RNA according to project specifications, often following strict protocols to ensure accuracy and reproducibility. They frequently utilize specialized laboratory equipment and maintain detailed records to support quality control and reporting requirements. Collaboration is integral, as they often work closely with molecular biologists, chemists, and quality assurance teams to troubleshoot issues and meet project deadlines. This teamwork enhances the development of custom oligonucleotides for research, diagnostics, or therapeutic applications.

What are the key skills and qualifications needed to thrive in the oligonucleotide position, and why are they important?

To thrive in an Oligonucleotide Specialist or Research Scientist role, a background in molecular biology, biochemistry, or a related life science—usually with a bachelor’s or advanced degree—is essential. Familiarity with DNA/RNA synthesis platforms, analytical instruments like HPLC and mass spectrometry, and quality control processes is crucial, along with knowledge of relevant regulatory standards. Attention to detail, strong problem-solving abilities, and effective teamwork skills help individuals excel in a laboratory environment. These competencies ensure precise design, synthesis, and validation of oligonucleotides, which are critical for quality research and development in biotechnology.

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oligonucleotide jobs near you
Infographic showing various Oligonucleotide job openings in the United States as of August 2026, with employment types broken down into 98% Full Time, and 2% Contract. Highlights an 88% Physical, 5% Hybrid, and 7% Remote job distribution, with an average salary of $48,570 per year, or $23.4 per hour.

Principal Scientist, Oligonucleotide (PMO, ASO) Development

Dyne Therapeutics

Waltham, MA • On-site

Full-time

Posted 7 days ago

Job description

Role Summary

The Principal Scientist of Oligonucleotide Development will lead the chemical synthesis strategy for PMO and modified ASO payload molecules, managing execution both internally and across CDMOs. This role oversees the early development aspects from preclinical process and analytical development leading into GMP manufacture for IND-enabling studies.

This role will ensure the delivery of robust, scalable, and cost-effective manufacturing processes, serve as the primary technical lead for external CDMOs, driving aggressive timelines while delivering well-characterized products optimized for our proprietary bioconjugation platform.

The Principal Scientist of Oligonucleotide Development will steer the development of preclinical assets and help define CMC strategies within a matrixed environment. The role will play a critical role in global regulatory filings (IND, IMPD, etc.) by authoring and reviewing key Module 3 sections. 

This role is based in Waltham, MA without the possibility of being a remote role. Physical presence onsite is expected on 4-5 days/week.

Key Responsibilities

Technical Leadership & Strategy

  • Drive Process Excellence: Lead the design, optimization, and execution of process development for PMO and modified ASO payload molecules, ensuring scalability for clinical supply.
  • Define Analytical Strategy: Support analytical development, focusing on robust impurity control strategies, raw material specifications, and comprehensive physicochemical characterization for both oligonucleotide payloads and conjugated protein drug substances.
  • Innovate & Improve: Proactively identify and implement emerging technologies and continuous improvement initiatives to enhance product quality and manufacturing efficiency.
  • Prepare technical source documents, publications, and oral presentations
  • Prepare and review relevant CMC and product related sections and documentation for regulatory submission (IND, IMPD etc.)
  • Review and approve documents related to development and cGMP operations, including Tech Transfer, Process Characterization, Master Batch Records (MBRs) and Campaign Summary Reports

External Partner & Project Management

  • Technology Transfer: Spearhead the seamless transfer of processes and analytical assays to external partners, ensuring technical success and data integrity.
  • Issue Resolution: Serve as the technical lead for resolving complex manufacturing or analytical challenges, driving timely and data-driven solutions.

Regulatory & Quality Compliance

  • Regulatory Authoring: Contribute to regulatory filings (IND, IMPD, etc.), ensuring high-quality, submission-ready Module 3 content.
  • GMP Oversight: Review and approve critical development and cGMP documentation, including Tech Transfer protocols, Master Batch Records (MBRs), and Campaign Summary Reports.
  • Knowledge Dissemination: Oversee the creation of technical source documents, publications, and high-level presentations for internal stakeholders and external forums.
Education & Experience
  • Bachelor's degree in Biochemistry, Chemical Engineering, Chemistry, or Pharmaceutical Sciences
  • 8+ years of relevant pharmaceutical/biotech industry experience (advanced degree preferred)
  • Oligonucleotide Expertise: Proven track record in the process chemistry and development of PMO and modified ASO oligonucleotides, including deep technical knowledge of synthesis and purification.
  • Experience in Research & Development preferably in a clinical-stage biotechnology company
  • External Management: Direct experience in the oversight of CDMOs, including managing technology transfers.
  • Analytical Depth: Technical proficiency in analytical development, including impurity control strategies and physicochemical characterization of payload and conjugated drug substances.
  • Strategic Problem Solving: Ability to navigate shifting priorities and evolving timelines using robust analytical and risk-mitigation capabilities.
  • Collaborative Influence: Exceptional interpersonal and communication skills, with a proven ability to lead and influence cross-functional teams, contractors, and third-party vendors.

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