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Oligonucleotide Jobs (NOW HIRING)

GSK

Scientist, Oligonucleotide Synthesis

Cambridge, MA · On-site

$96K - $160K/yr

  • Medical

  • Retirement

  • PTO

Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries. * Perform ...

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Oligonucleotide information

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How much do oligonucleotide jobs pay per hour?

As of Aug 17, 2026, the average hourly pay for oligonucleotide in the United States is $23.35, according to ZipRecruiter salary data. Most workers in this role earn between $18.27 and $26.44 per hour, depending on experience, location, and employer.

What is an oligonucleotide?

An Oligonucleotide job typically involves the synthesis, purification, analysis, and quality control of short DNA or RNA sequences used in research, diagnostics, and therapeutics. Professionals in this role may work in biotechnology, pharmaceutical, or academic settings, ensuring the accurate production of oligonucleotides for applications such as PCR, gene editing, and drug development. Responsibilities often include operating automated synthesizers, troubleshooting synthesis issues, and maintaining laboratory protocols. Strong knowledge of molecular biology, chemistry, and instrumentation is essential.

What are the typical responsibilities of an oligonucleotide specialist, and how does the role collaborate with others in the lab?

Oligonucleotide Specialists are primarily responsible for synthesizing, purifying, and characterizing short strands of DNA or RNA according to project specifications, often following strict protocols to ensure accuracy and reproducibility. They frequently utilize specialized laboratory equipment and maintain detailed records to support quality control and reporting requirements. Collaboration is integral, as they often work closely with molecular biologists, chemists, and quality assurance teams to troubleshoot issues and meet project deadlines. This teamwork enhances the development of custom oligonucleotides for research, diagnostics, or therapeutic applications.

What are the key skills and qualifications needed to thrive in the oligonucleotide position, and why are they important?

To thrive in an Oligonucleotide Specialist or Research Scientist role, a background in molecular biology, biochemistry, or a related life science—usually with a bachelor’s or advanced degree—is essential. Familiarity with DNA/RNA synthesis platforms, analytical instruments like HPLC and mass spectrometry, and quality control processes is crucial, along with knowledge of relevant regulatory standards. Attention to detail, strong problem-solving abilities, and effective teamwork skills help individuals excel in a laboratory environment. These competencies ensure precise design, synthesis, and validation of oligonucleotides, which are critical for quality research and development in biotechnology.

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Oligonucleotide jobs near you
Infographic showing various Oligonucleotide job openings in the United States as of August 2026, with employment types broken down into 96% Full Time, and 4% Contract. Highlights an 89% Physical, 5% Hybrid, and 6% Remote job distribution, with an average salary of $48,570 per year, or $23.4 per hour.

Oligonucleotide Scientist II

Software Guidance & Assistance

South San Francisco, CA • On-site

Other

Re-posted 21 days ago

Job description

Software Guidance & Assistance, Inc., (SGA), is searching for an Oligonucleotide Scientist II for a CONTRACT assignment with one of our premier Pharmaceutical clients in San Francisco, CA .
The Client is seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department. We are looking for a candidate with experience in oligonucleotide discovery and synthesis to support our new oligonucleotide therapeutics discovery group. Experience in delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The successful candidate will join an interdisciplinary chemistry team working in RNAi biology research and will contribute positively to its developing culture.
Responsibilities :
  • The candidate will work in an oligonucleotide therapeutic drug discovery research lab and interface across different therapeutic areas, including neuroscience, immunology and oncology, to help build a comprehensive therapeutic discovery strategy.
  • Good understanding and also troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus.
  • Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units.
  • Perform literature reviews, propose, and execute nucleic acid chemistry plans, coordinate chemistry and biology data to support oligonucleotide compound progression.
  • Establish methods for scaled-up synthesis of lead molecules and coordinate material delivery for preclinical studies.
  • Maintaining a high level of productivity in the laboratory setting to meet the timelines for in vitro and in vivo studies.
Required Skills :
  • The candidate must have hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry.
  • The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
  • The pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics is preferred.
  • Good communication and interpersonal skills are essential and will be evaluated during the interview process.
  • The ideal candidate should be highly motivated and have strong problem-solving, analytical, communication and organizational skills.
Preferred Skills :
  • A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action is preferred. Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation is desirable.

SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. Please find us at .
SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status. We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company to request an accommodation or assistance regarding our policy.

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