ZipRecruiter

Log In

1

Oligonucleotide Jobs (NOW HIRING)

GSK

Scientist, Oligonucleotide Synthesis

Cambridge, MA · On-site

$96K - $160K/yr

Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities of ASOs, siRNA, SSO, and RNA editors with routine and novel next generation amidite chemistries. * Perform ...

next page

Showing results 1-20

All JobsOligonucleotide Jobs

Oligonucleotide information

See salary details

$14

$23

$39

How much do oligonucleotide jobs pay per hour?

As of Jul 7, 2026, the average hourly pay for oligonucleotide in the United States is $23.35, according to ZipRecruiter salary data. Most workers in this role earn between $18.27 and $26.44 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Oligonucleotide position, and why are they important?

To thrive in an Oligonucleotide Specialist or Research Scientist role, a background in molecular biology, biochemistry, or a related life science—usually with a bachelor’s or advanced degree—is essential. Familiarity with DNA/RNA synthesis platforms, analytical instruments like HPLC and mass spectrometry, and quality control processes is crucial, along with knowledge of relevant regulatory standards. Attention to detail, strong problem-solving abilities, and effective teamwork skills help individuals excel in a laboratory environment. These competencies ensure precise design, synthesis, and validation of oligonucleotides, which are critical for quality research and development in biotechnology.

What is an Oligonucleotide job?

An Oligonucleotide job typically involves the synthesis, purification, analysis, and quality control of short DNA or RNA sequences used in research, diagnostics, and therapeutics. Professionals in this role may work in biotechnology, pharmaceutical, or academic settings, ensuring the accurate production of oligonucleotides for applications such as PCR, gene editing, and drug development. Responsibilities often include operating automated synthesizers, troubleshooting synthesis issues, and maintaining laboratory protocols. Strong knowledge of molecular biology, chemistry, and instrumentation is essential.

What typical responsibilities does an Oligonucleotide Specialist handle day-to-day, and how does the role collaborate with others in the lab?

Oligonucleotide Specialists are primarily responsible for synthesizing, purifying, and characterizing short strands of DNA or RNA according to project specifications, often following strict protocols to ensure accuracy and reproducibility. They frequently utilize specialized laboratory equipment and maintain detailed records to support quality control and reporting requirements. Collaboration is integral, as they often work closely with molecular biologists, chemists, and quality assurance teams to troubleshoot issues and meet project deadlines. This teamwork enhances the development of custom oligonucleotides for research, diagnostics, or therapeutic applications.

More about Oligonucleotide jobs
What cities are hiring for Oligonucleotide jobs? Cities with the most Oligonucleotide job openings:
What are the most commonly searched types of Oligonucleotide jobs? The most popular types of Oligonucleotide jobs are:
What states have the most Oligonucleotide jobs? States with the most job openings for Oligonucleotide jobs include:
What job categories do people searching Oligonucleotide jobs look for? The top searched job categories for Oligonucleotide jobs are:
Oligonucleotide jobs near you
Infographic showing various Oligonucleotide job openings in the United States as of July 2026, with employment types broken down into 96% Full Time, 1% Part Time, 1% Temporary, and 2% Contract. Highlights an 90% Physical, 4% Hybrid, and 6% Remote job distribution, with an average salary of $48,570 per year, or $23.4 per hour.
Oligonucleotide Scientist II

Oligonucleotide Scientist II

Lancesoft

South San Francisco, CA • On-site

$54/hr

Temporary

This job post has expired today. Applications are no longer accepted.

Job description


The Position:
We are seeking a creative, self-motivated, collaborative Contractor/Scientist-II to join the
Nucleic Acid Design and Discovery (NADD) team within ProteinSciences (PS) department at
. We are looking for a candidate with experience in oligonucleotide discovery and
synthesis to support our new oligonucleotide therapeutics discovery group. Experience in
delivery of oligonucleotide therapeutics, large molecule drug discovery, would be preferred. The
successful candidate will join an interdisciplinary chemistry team working in RNAi biology
research and will contribute positively to its developing culture.
Key Responsibilities:
. The candidate will work in an oligonucleotide therapeutic drug discovery research lab
and interface across different therapeutic areas, including neuroscience, immunology
and oncology, to help build a comprehensive therapeutic discovery strategy.
. Good understanding and also troubleshooting experience in oligonucleotide synthesis,
impurity profiling is a plus.
. Collaborate with other scientists to maintain common lab equipment such as oligo
synthesizers, HPLC and desalting units.
. Perform literature reviews, propose, and execute nucleic acid chemistry plans,
coordinate chemistry and biology data to support oligonucleotide compound
progression.
. Establish methods for scaled-up synthesis of lead molecules and coordinate material
delivery for preclinical studies.
. Maintaining a high level of productivity in the laboratory setting to meet the timelines
for in vitro and in vivo studies.
Requirements:
. The candidate must have hands-on experience in oligonucleotide synthesis using
automated oligo synthesizers, Client nucleic acid chemistry, oligonucleotide purification
and characterization using HPLC and mass spectrometry.
. The qualified individual will possess a BS/MS in Organic Chemistry or related discipline.
. The pharmaceutical or biotechnology industry experience in research and development
of RNAi therapeutics is preferred.
. A good understanding of nucleic acid therapeutic modalities, modification chemistries,
sequence selection, and mechanism of action is preferred. Relevant experience in
oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or
bio-conjugation is desirable.
. Good communication and interpersonal skills are essential and will be evaluated during
the interview process.
. The ideal candidate should be highly motivated and have strong problem-solving,
analytical, communication and organizational skills.
Meet Your Recruiter
Manuja Gowda
LanceSoft logo

About LanceSoft

Sourced by ZipRecruiter

Established in 2000, LanceSoft is a Certified MBE and Woman-Owned organization. Lancesoft Inc. is one of the highest rated companies in the industry. We have been recognized as one of the Largest Staffing firms and ranked in the top 50 fastest Growing Healthcare Staffing firms in 2022. Lancesoft offers short- and long-term contracts, permanent placements, and travel opportunities to credentialed and experienced professionals throughout the United States. We pride ourselves on having industry leading benefits. We understand the importance of partnering with an expert who values your needs, which is why we're 100% committed to finding you an assignment that best matches your career and lifestyle goals. Our team of experienced career specialists takes the time to understand your needs and match you with the right job Lancesoft has been chosen by Staffing Industry Analysts as one of the Best Staffing Firms to Work for.LanceSoft specializes in providing Registered Nurses, Nurse Practitioners, LPNs/LVNs, Social Workers, Medical Assistants, and Certified Nursing Assistants to work in Acute Care Centers, Skilled Nursing Facilities, Long-Term Care centers, Rehab Facilities, Behavioral Health Centers, Drug & Alcohol Facilities, Home Health & Community Health, Urgent Care Clinics, and many other provider-based facilities.

Industry

Recruiting and staffing services

Company size

1,001 - 5,000 Employees

Headquarters location

Herndon, VA, US

Year founded

2000

Social media

FacebookTwitter

View All LanceSoft Jobs

Apply