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How much do oligonucleotide jobs pay per hour?

As of Aug 17, 2026, the average hourly pay for oligonucleotide in the United States is $23.35, according to ZipRecruiter salary data. Most workers in this role earn between $18.27 and $26.44 per hour, depending on experience, location, and employer.

What is an oligonucleotide?

An Oligonucleotide job typically involves the synthesis, purification, analysis, and quality control of short DNA or RNA sequences used in research, diagnostics, and therapeutics. Professionals in this role may work in biotechnology, pharmaceutical, or academic settings, ensuring the accurate production of oligonucleotides for applications such as PCR, gene editing, and drug development. Responsibilities often include operating automated synthesizers, troubleshooting synthesis issues, and maintaining laboratory protocols. Strong knowledge of molecular biology, chemistry, and instrumentation is essential.

What are the typical responsibilities of an oligonucleotide specialist, and how does the role collaborate with others in the lab?

Oligonucleotide Specialists are primarily responsible for synthesizing, purifying, and characterizing short strands of DNA or RNA according to project specifications, often following strict protocols to ensure accuracy and reproducibility. They frequently utilize specialized laboratory equipment and maintain detailed records to support quality control and reporting requirements. Collaboration is integral, as they often work closely with molecular biologists, chemists, and quality assurance teams to troubleshoot issues and meet project deadlines. This teamwork enhances the development of custom oligonucleotides for research, diagnostics, or therapeutic applications.

What are the key skills and qualifications needed to thrive in the oligonucleotide position, and why are they important?

To thrive in an Oligonucleotide Specialist or Research Scientist role, a background in molecular biology, biochemistry, or a related life science—usually with a bachelor’s or advanced degree—is essential. Familiarity with DNA/RNA synthesis platforms, analytical instruments like HPLC and mass spectrometry, and quality control processes is crucial, along with knowledge of relevant regulatory standards. Attention to detail, strong problem-solving abilities, and effective teamwork skills help individuals excel in a laboratory environment. These competencies ensure precise design, synthesis, and validation of oligonucleotides, which are critical for quality research and development in biotechnology.

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Oligonucleotide jobs near you
Infographic showing various Oligonucleotide job openings in the United States as of August 2026, with employment types broken down into 97% Full Time, 1% Part Time, and 2% Contract. Highlights an 89% Physical, 5% Hybrid, and 6% Remote job distribution, with an average salary of $48,570 per year, or $23.4 per hour.

Research Scientist I or II, Oligonucleotide Chemistry

Novartis

Cambridge, MA

Full-time

Retirement

Posted 4 days ago

Novartis rating

7.5

Company rating: 7.5 out of 10

Based on 17 frontline employees who took The Breakroom Quiz

64th of 86 rated pharmaceutical

Job description

Job Description Summary

Job Title: Research Scientist I or II, Oligonucleotide Chemistry
#LI-Onsite
Location: Cambridge, USA
Relocation Support: This role is based in Cambridge, USA. Novartis is unable to offer relocation support: please only apply if accessible.
Imagine helping shape the future of RNA-based medicines through hands-on scientific innovation. At Novartis, we're pushing the boundaries of xRNA therapeutics to address some of the world's most challenging diseases, and we're looking for a talented scientist to join us on that journey. As a Research Scientist in Oligonucleotide Chemistry, you'll play a key role in synthesizing, optimizing, and characterizing therapeutic oligonucleotides while collaborating with a diverse team of experts across discovery and development. This is an exciting opportunity to apply your scientific expertise, grow your technical skills, and contribute directly to groundbreaking therapies that have the potential to transform patients' lives.


Job Description

Key Responsibilities
  • Execute solid-phase synthesis of research-scale oligonucleotides using advanced automated DNA and RNA synthesizers.
  • Purify, desalt, and characterize oligonucleotides using chromatographic and mass spectrometry techniques.
  • Develop and optimize synthesis, purification, and analytical methods to improve performance and reproducibility.
  • Operate, maintain, and troubleshoot laboratory instrumentation supporting oligonucleotide production and analysis.
  • Prepare and maintain standard operating procedures to support high-quality and consistent laboratory practices.
  • Organize, analyze, and document experimental results using electronic laboratory notebook systems.
  • Contribute effectively within a collaborative, fast-paced research environment focused on therapeutic innovation.
Essential Requirements
  • Bachelor of Science or Master of Science in Chemistry or a related scientific discipline.
  • One to three years of laboratory experience in academic or industrial research environments.
  • Hands-on experience with automated solid-phase synthesizers and therapeutic oligonucleotide synthesis workflows.
  • Proficiency in oligonucleotide purification, characterization, and analysis using chromatography and mass spectrometry techniques.
  • Understanding of RNA therapeutics and their application in biological systems.
  • Strong collaboration, adaptability, and self-motivation in a fast-paced scientific environment.
Desirable Requirements
  • Experience supporting oligonucleotide process development, optimization, or technology innovation initiatives.
  • Excellent scientific communication skills with the ability to present findings to multidisciplinary teams.

Rewards

At Novartis,we'recommitted to reimagining medicine together - and rewarding the people who make it happen.

The rewards of being part of our team go far beyond base pay and incentives.We also offer a variety of competitive benefits inkindto help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeingresourcesand global recognition programs. In addition, we provide flexible and hybrid working options, where possible, anda minimum of14 weekspaid parental leave.

Expected Annual Base Salary Range for role:

  • US:66,800.00 - 124,000.00 USD Annual

The salary offered isdeterminedbased on gender-neutralobjectives, such as relevant skills,competenciesand experiencein accordance withthe Novartis pay setting policy and upon joining Novartis will be reviewed periodically.

In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Further details will be provided during the application process.

Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse,equitableand inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.

Readourbrochureto learn more about our global total rewards offering:https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf

Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the applicationprocess.

Commitment to Diversity and Inclusion / EEO paragraph:

Novartis is committed to building an outstanding, inclusive work environment and diverseteams'representativeof the patients and communities we serve.

Why Novartis:Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating,supportingand inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together?https://www.novartis.com/about/strategy/people-and-culture


EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.


Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.


Salary Range

$66,800.00 - $124,000.00


Skills Desired

Algorithms, Analytical Chemistry, Automation, Chemical Analysis, Chemical Biology, Chemical Laboratory, Chemical Synthesis, Chemistry, Collaboration, Creativity, Data Analysis, Drug Development, Innovation, Medicinal Chemistry, Organic Chemistry, Pharmaceutical Industry, Physics, Team Player

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