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How much do oligonucleotide jobs pay per hour?

As of Sep 4, 2026, the average hourly pay for oligonucleotide in the United States is $23.35, according to ZipRecruiter salary data. Most workers in this role earn between $18.27 and $26.44 per hour, depending on experience, location, and employer.

What is an oligonucleotide?

An Oligonucleotide job typically involves the synthesis, purification, analysis, and quality control of short DNA or RNA sequences used in research, diagnostics, and therapeutics. Professionals in this role may work in biotechnology, pharmaceutical, or academic settings, ensuring the accurate production of oligonucleotides for applications such as PCR, gene editing, and drug development. Responsibilities often include operating automated synthesizers, troubleshooting synthesis issues, and maintaining laboratory protocols. Strong knowledge of molecular biology, chemistry, and instrumentation is essential.

What are the typical responsibilities of an oligonucleotide specialist, and how does the role collaborate with others in the lab?

Oligonucleotide Specialists are primarily responsible for synthesizing, purifying, and characterizing short strands of DNA or RNA according to project specifications, often following strict protocols to ensure accuracy and reproducibility. They frequently utilize specialized laboratory equipment and maintain detailed records to support quality control and reporting requirements. Collaboration is integral, as they often work closely with molecular biologists, chemists, and quality assurance teams to troubleshoot issues and meet project deadlines. This teamwork enhances the development of custom oligonucleotides for research, diagnostics, or therapeutic applications.

What are the key skills and qualifications needed to thrive in the oligonucleotide position, and why are they important?

To thrive in an Oligonucleotide Specialist or Research Scientist role, a background in molecular biology, biochemistry, or a related life science—usually with a bachelor’s or advanced degree—is essential. Familiarity with DNA/RNA synthesis platforms, analytical instruments like HPLC and mass spectrometry, and quality control processes is crucial, along with knowledge of relevant regulatory standards. Attention to detail, strong problem-solving abilities, and effective teamwork skills help individuals excel in a laboratory environment. These competencies ensure precise design, synthesis, and validation of oligonucleotides, which are critical for quality research and development in biotechnology.

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oligonucleotide jobs near you
Infographic showing various Oligonucleotide job openings in the United States as of August 2026, with employment types broken down into 98% Full Time, and 2% Contract. Highlights an 88% Physical, 5% Hybrid, and 7% Remote job distribution, with an average salary of $48,570 per year, or $23.4 per hour.

Principal Scientist - Oligonucleotide Design and Chemistry

Genentech, Inc.

South San Francisco, CA • On-site

$143K - $266K/yr

Full-time

Posted 25 days ago

Key responsibilities

  • Lead the design, synthesis, purification, and characterization of novel oligonucleotide modalities for drug discovery programs.

  • Guide and mentor junior scientists in chemical synthesis, troubleshooting, impurity profiling, and analytical characterization.

  • Partner with biology and biochemistry teams to design in vitro/in vivo assays, interpret data, and support rapid decision-making.

Genentech rating

8.8

Company rating: 8.8 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

11th of 86 rated pharmaceutical

Job description

The Opportunity
The Therapeutic Modalities and Technologies group in the Protein Sciences organization at Genentech is responsible for the design and generation of new therapeutic modalities that combine the engineering and analytical principles of multiple scientific disciplines. We are excited to be at the forefront of therapeutic design by generating molecules with unique mechanisms of action. We are seeking a talented and dynamic individual with extensive oligonucleotide experience to join our team as a Principal Scientist (Group Leader), and support our nucleic-acid based medicines portfolio. This role offers a significant opportunity to impact our science and pipeline by leading the design and synthesis of novel oligonucleotides for drug discovery programs. The successful candidate will be a technical leader taking on responsibilities across the portfolio.
  • Drive Pipeline Innovation: Lead the design, synthesis, purification, and characterization of novel oligonucleotide modalities (e.g., ASOs, siRNAs, saRNAs) across drug discovery programs.
  • Lead & Mentor: Guide and mentor junior scientists in chemical synthesis, troubleshooting, impurity profiling, and analytical characterization.
  • Champion Cross-Disciplinary Collaboration: Partner closely with biology and biochemistry teams to design in vitro/in vivo assays, interpret complex data, and facilitate rapid decision-making.
  • Shape Strategy: Serve as a technical authority across the nucleic-acid portfolio, communicating scientific progress, key milestones, and insights to multidisciplinary project teams and stakeholders.
  • Lab Excellence: Manage cutting-edge laboratory instrumentation and maintain smooth, efficient lab operations to accelerate research outcomes.
  • Inspire Team Culture: Foster an open, highly collaborative, and inclusive environment that encourages bold scientific curiosity and innovative problem-solving.

Who You Are
You are a passionate, collaborative scientific leader with deep technical expertise in oligonucleotide chemistry who thrives in a team-oriented research environment.
  • Education & Experience: Ph.D. in Organic/Medicinal Chemistry, Chemical Biology, Oligonucleotide Chemistry, or a closely related field, with 3+ years of postdoctoral or industry experience.
  • Modality Expertise: Strong hands-on knowledge of siRNA and/or ASO therapeutics, including synthesis, purification, analytics, and fluency with diverse backbone modifications and delivery technologies.
  • Scientific Leadership: Proven track record of leading scientific initiatives, mentoring team members, and driving cross-functional collaborations (evidenced by publications or patents).
  • Communication: Excellent verbal and written communication skills with the ability to articulate complex scientific concepts to diverse audiences.

Preferred
  • Bioconjugation Skills: Experience in designing optimized oligonucleotide conjugates, linker discovery, or bioconjugation optimization is an asset.

At Roche, you'll thrive in a culture that values different perspectives and creates a place of belonging, where we challenge ourselves to excel and achieve strong results, together.
This position is located in South San Francisco and is an on-site research position.
Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of California is $143,200.00 - 266,000.00 USD. Annual Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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About Genentech

Sourced by ZipRecruiter

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Industry

Scientific research and development services

Company size

10,000+ Employees

Headquarters location

South San Francisco, CA, US

Year founded

1976

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