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Weekend Prn Rn Jobs in Littleton, CO (NOW HIRING)

PRN RN

Aurora, CO · On-site

$36 - $46/hr

Overview Rocky Mountain Cancer Centers, Colorado's largest and most comprehensive provider of cancer care has an exciting opportunity for a PRN Registered Nurse to float between Aurora and Centennail.

PRN RN

Thornton, CO · On-site

$36 - $46/hr

Overview Rocky Mountain Cancer Centers, Colorado's largest and most comprehensive provider of cancer care has an exciting opportunity for a PRN Registered Nurse to float between our NoCo division ...

PRN RN

Aurora, CO · On-site

$36 - $46/hr

Overview Rocky Mountain Cancer Centers, Colorado's largest and most comprehensive provider of cancer care has an exciting opportunity for a PRN Registered Nurse to float between Aurora and Centennail.

PRN RN

Thornton, CO · On-site

$36 - $46/hr

Overview Rocky Mountain Cancer Centers, Colorado's largest and most comprehensive provider of cancer care has an exciting opportunity for a PRN Registered Nurse to float between our NoCo division ...

Registered Nurse

Lakewood, CO · On-site

$55 - $69/hr

Sierra Post Acute is Hiring Part-Time/PRN Registered Nurses!Open Positions: PRN 6am-6pm and 6pm-6am; Part Time 6am-6pm on Thursday;At Sierra Post Acute, we take pride in working together to provide ...

New

Registered Nurse

Lafayette, CO · On-site

$41 - $51/hr

Coal Creek Post Acute and Assisted Living is Hiring Part-Time and PRN RN's! Shifts : Part Time & PRN 12-hour shifts, 6am-6pm & 6pm-6am At Coal Creek Post Acute & Assisted Living , we're committed to ...

Registered Nurse

Lakewood, CO · On-site

$40 - $50/hr

Sierra Post Acute is Hiring Part-Time/PRN Registered Nurses! Open Positions: PRN 6am-6pm and 6pm-6am; Part Time 6am-6pm on Thursday; At Sierra Post Acute , we take pride in working together to ...

The Birth Center PRN RN role provides opportunities for you to work to the top of your scope and ... You will be scheduled for both day, night and weekend shifts. You will have the opportunity to take ...

PRN RN

Denver, CO · On-site

$40 - $50/hr

As a Registered Nurse, they will demonstrate professional nursing skills in assessing, planning, implementing, and evaluating nursing care from admission to discharge. DUTIES AND RESPONSIBILITIES:

PRN RN

Denver, CO · On-site

$75 - $95/hr

As a Registered Nurse, they will demonstrate professional nursing skills in assessing, planning ... This is a PRN role and you will be scheduled based on business needs. Equal Employment Opportunity ...

PRN RN

Denver, CO · On-site

$55 - $69/hr

As a Registered Nurse, they will demonstrate professional nursing skills in assessing, planning ... This is a PRN role and you will be scheduled based on business needs. Equal Employment Opportunity ...

Showing results 21-40

Weekend Prn Rn information

See Littleton, CO salary details

$19

$36

$53

How much do weekend prn rn jobs pay per hour?

As of Sep 4, 2026, the average hourly pay for weekend prn rn in Littleton, CO is $36.53, according to ZipRecruiter salary data. Most workers in this role earn between $29.13 and $42.12 per hour, depending on experience, location, and employer.

What is a Weekend PRN RN?

A Weekend PRN RN (As Needed Registered Nurse) is a nursing position where the nurse works primarily on weekends and on an as-needed basis. These roles are typically found in hospitals, nursing homes, and healthcare facilities that require additional weekend staffing. PRN nurses do not usually have a set schedule and may be called to fill in for staff shortages. This role offers flexibility but may not guarantee a certain number of hours. Weekend PRN RNs must still meet licensing and certification requirements like full-time nurses.

What are the typical shift expectations and workload for a Weekend PRN RN?

Weekend PRN RN positions usually require nurses to work flexible hours on Saturdays and Sundays, with potential opportunities for additional shifts based on staffing needs. The workload can vary each weekend, depending on patient census and acuity, so adaptability is important. These roles often involve collaborating with a leaner weekend team, requiring strong teamwork and autonomy. While you may not have a set schedule every week, PRN positions can offer valuable hands-on experience and are ideal for nurses seeking flexibility or supplemental income.

What are the key skills and qualifications needed to thrive in the Weekend PRN RN position, and why are they important?

To thrive as a Weekend PRN RN, you need a current RN license, strong clinical assessment abilities, and experience in acute or long-term care settings. Familiarity with electronic health record (EHR) systems, medication administration protocols, and facility-specific safety procedures is important. Flexibility, excellent communication, and the ability to work independently are valuable soft skills for managing varied shifts and patient needs. These competencies ensure that you can provide high-quality care and respond effectively to weekend staffing and patient demands.

Do PRN registered nurses have to work weekends?

PRN registered nurses are scheduled on an as-needed basis and are not typically required to work weekends unless assigned to weekend shifts. Their work schedule depends on the facility's staffing needs and the nurse's availability, often offering flexibility. However, some PRN positions may include weekend shifts if the facility requires coverage during those times.

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For Weekend Prn Rn jobs in Littleton, CO, the most frequently searched job titles are:

What job categories do people searching Weekend Prn Rn jobs in Littleton, CO look for?

The top searched job categories for Weekend Prn Rn jobs in Littleton, CO are:

What cities near Littleton, CO are hiring for Weekend Prn Rn jobs?

Cities near Littleton, CO with the most Weekend Prn Rn job openings:

Infographic showing various Weekend Prn Rn job openings in Littleton, CO as of August 2026, with employment types broken down into 1% As Needed, 68% Full Time, 27% Part Time, 3% Contract, and 1% Nights. Highlights an 94% Physical, 1% Hybrid, and 5% Remote job distribution, with an average salary of $75,991 per year, or $36.5 per hour.

$36 - $46/hr

Per diem

Posted 14 days ago


Key responsibilities

  • Administers chemotherapy, hydration, and other medications under the supervision of a physician.

  • Performs venipuncture, accesses implanted ports, maintains central line catheter devices, and programs infusion pumps.

  • Documents nursing assessments, patient teaching, medication administration, and communicates relevant information to physicians.


US Oncology rating

7.1

Company rating: 7.1 out of 10

Based on 109 frontline employees who took The Breakroom Quiz

380th of 898 rated healthcare providers


Job description

Overview

Rocky Mountain Cancer Centers, Colorado's largest and most comprehensive provider of cancer care has an exciting opportunity for a PRN Registered Nurse to float between Aurora and Centennail.

We realize that it sounds cliché but it is true - taking care of cancer patients is a calling. It’s much more than a job. Each of us has a unique story that brought us to Rocky Mountain Cancer Centers (RMCC), but those stories usually share common themes of care, compassion, and commitment.

No matter the role each RMCC team member serves in, the goal is the same: to provide the best care possible for each and every one of our patients. Whether we are a nurse holding our patient’s hand, or a scheduler on the phone finding an appointment that fits into a patient’s schedule, we are deeply connected to our patients and do what we can to help.

If this sounds like you, we’d love to have you join our team.

Salary Range: $36.00-46.00

Pay is based on several factors including but not limited to education, work experience, certification, etc. 

Nurses with OCN certification are eligible for OCN Incentive Pay after 90 days of employment or upon obtainment of certification.


Responsibilities
  • Administers chemotherapy, hydration and other medications under the direction and supervision of a physician.
  • Maintains knowledge of drug reimbursement procedures. Completes all chemotherapy charge forms.
  • Assures pre-authorization and appropriate consent forms are obtained prior to administration of therapies.
  • Demonstrates knowledge of ambulatory infusion pump use and maintenance, cleaning pumps after use, and proper documentation of pump usage.
  • Facilitates dose modification by assessing patient, assessing labs, consulting protocol or treatment plan, calculating dose, and consulting physician regarding dosage modifications, including problems and symptom management.
  • Performs venipuncture, accesses implanted ports and maintains central lines catheter devices.
  • Administers all medications using correct medication product, dosage/amount, route, time and technique.
  • Displays appropriate technical skills for the administration of chemotherapy and medications to include, but not limited to, venipuncture, central line access and infusion devices, programs portable infusion pumps for continuous drug delivery, and provides instruction to the patient and/or caregiver in the use of the pump at home.
  • Documents nursing assessments, patient teaching and fluid and medication administration in the patient chart.
  • Communicates all pertinent information and any interventions to the physician.
  • Triages patient phone calls as needed and documents relevant information in the patient's chart.
  • Assesses patient/family needs and provides teaching and other instructional material

Qualifications

Graduate from an accredited program for professional nursing education, BSN preferred.

RN state license and current registration with the State Board of Nursing in practicing state. 

Current Basic Life Support (BLS) certification. 
Must maintain continuing education requirements. 

Minimum two years nursing experience required, oncology experience preferred.

 

Working Conditions:

Environment-

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.  There is a possible exposure to communicable diseases, toxic substances, ionizing radiation, medical preparations and other conditions common to an oncology/hematology clinic environment.

Physical Requirements (Lifting, standing, etc.) –

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.  Requires full range of body motion including handling and lifting patients, manual and finger dexterity, and eye-hand coordination.  Requires standing and walking for extensive periods of time.  Occasionally lifts and carries items weighing up to 40 lbs.  Requires corrected vision and hearing to normal range.

All qualified candidates are required to pass a background check and non-federal drug test (which excludes marijuana) post offer of employment and prior to hire.

This job posting will remain open until we have identified an adequate applicant pool. Applicants are strongly encouraged to apply early.  To apply for this position, start the process by clicking the blue "apply" button.

Qualifications:

Graduate from an accredited program for professional nursing education, BSN preferred.

RN state license and current registration with the State Board of Nursing in practicing state. 

Current Basic Life Support (BLS) certification. 
Must maintain continuing education requirements. 

Minimum two years nursing experience required, oncology experience preferred.

 

Working Conditions:

Environment-

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.  There is a possible exposure to communicable diseases, toxic substances, ionizing radiation, medical preparations and other conditions common to an oncology/hematology clinic environment.

Physical Requirements (Lifting, standing, etc.) –

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.  Requires full range of body motion including handling and lifting patients, manual and finger dexterity, and eye-hand coordination.  Requires standing and walking for extensive periods of time.  Occasionally lifts and carries items weighing up to 40 lbs.  Requires corrected vision and hearing to normal range.

All qualified candidates are required to pass a background check and non-federal drug test (which excludes marijuana) post offer of employment and prior to hire.

This job posting will remain open until we have identified an adequate applicant pool. Applicants are strongly encouraged to apply early.  To apply for this position, start the process by clicking the blue "apply" button.

Education:UNAVAILABLEEmployment Type: PER_DIEM

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