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Senior Vice President,Preclinical Toxicology

NurixTherapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligaseexpertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements.Nurixaims toestablishdegrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Senior Vice President, Toxicology (Safety Pharmacology) leadsNurix'snonclinical safety function and reports to the Chief Scientific Officer. This role sets toxicologyandsafety pharmacology strategy across the portfolio, from discovery through clinical development, andrepresentsToxicology to senior management, the Board, external partners, and regulatory authorities.

The SVP operates across three dimensions: leading aninternal team and managing the department's CRO relationships, budget, and study portfolio; setting strategic direction for nonclinical safety across programs and the portfolio; and executing with the scientific rigor and credibility to influence program-level decisions and Nurix's broader R&D direction.

• Set toxicology and safety pharmacology strategy across the discovery, preclinical, and clinical portfolio, and make sure nonclinical safety plansalignwith the company's development priorities and risk tolerance.

• Represent Toxicology on the Research & Early Discovery leadership team andotherinternalorcollaborationleadership teams,acting asa key contributortoportfolio prioritization, program governance, and related decisions.

• Lead and develop aninternal Toxicology team, including hiring, mentoring, and setting priorities as workload and the portfolio evolve.

• Direct the design and execution of preclinical pharmacology, pharmacokinetic, mammalian toxicology, and genetic toxicology IND-enabling studies (GLP and non-GLP), ensuring packages meet regulatory filing standards.

• Manage the Toxicologydepartmentbudget and resourcing, including decisions about what stays in-house versus what goes to CRO partners.

• Select and oversee the CRO and external partner network, including contracting, risk management, and quality oversight of outsourced GLP and non-GLP studies.

• Serve as the senior toxicology representative in interactions with FDA and other health authorities, including IND, CTA, NDA, BLA, andMAAsubmissions and agency meetings.

• Communicate toxicology findings and risk assessments clearly to program teams, senior management, and the Board, translating nonclinical safety data into practical implications for decision-making.

• Provide toxicology and safety input on business development activities, including due diligence on in-licensing or partnership opportunities.

• Workcross-functionally withresearch,CMCandclinicalteams toresolve nonclinical safety issues thatdevelopacross discovery and developmentprograms, andassess the relevance of toxicological findings to human risk.

• RepresentNurixToxicology externally,including withkey opinion leaders, industry groups, and regulatory forums.

• Ph.D., M.D., or D.V.M. in Toxicology, Pharmacology, ora relateddiscipline.

• Minimum15years of drug development experience in the pharmaceutical or biotechnology industry, including experience leading a toxicology or nonclinical safetyfunctionTrackrecord advancing multiple programs from IND through Phase I, II, and III clinical development, with direct experience authoring and defending FDA and international regulatory submissions.

• Experience with ADCs (Antibody-Drug Conjugate) and small molecule stronglypreferred

• Experience presenting toxicology and nonclinical safetystrategyto senior management and external stakeholders, including investors and partners.

• People-leadership experience, including hiring, developing, and managing a team, plus experience owning a department budget.

• Strong knowledge of safety pharmacology and toxicology study design in compliance with GLP, ICH, FDA, and EMA guidelines across multiple therapeutic modalities.

• Proven experience preparing and defending regulatory submissions (IND, CTA, NDA, BLA, MAA, etc.) in direct interactions with global regulatory authorities.

• Experience contributing a toxicology and safety perspective to business development or due diligence activities preferred.

• Strong communicationskills, with the ability to influence senior leadership and represent the function credibly outside the company.

• Certification by the American Board of Toxicology (D.A.B.T.)requiredor strongly preferred.

• Travelrequiredas needed.

• Strong teamorientation; highly collaborative

• Solutions and results-oriented focus

• Hands-on approach; resourceful and open to diverse points of view

Salary Range:$360K – $420K

Location:Brisbane, CA (Onsite role)

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