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Variant Interpretation Scientist Jobs (NOW HIRING)

Washington University of St. Louis

$77K - $120K/yr

Focus of the position is on all aspects of genetic variant analysis, curation, and interpretation ... Scientific Literature, Stress Management, Team Collaboration, Working Independently Grade C14 ...

Mayo Foundation for Medical Education and Research

$100 - $125/hr

The Variant Scientist develops and maintains gene-level curation resources to support clinical test interpretation. The Variant Scientist participates as appropriate in gene/variant curation-focused ...

Astrix Inc

Associate AI Scientist

South San Francisco, CA · On-site

$30 - $38/hr

Job Title: Associate AI Scientist (Contract) Location: South San Francisco, CA (Onsite with ... The work supports research efforts in genomics, regulatory biology, and variant interpretation. Key ...

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Variant Interpretation Scientist information

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$36.5K

$79.4K

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How much do variant interpretation scientist jobs pay per year?

As of Sep 8, 2026, the average yearly pay for variant interpretation scientist in the United States is $79,408.00, according to ZipRecruiter salary data. Most workers in this role earn between $57,500.00 and $93,000.00 per year, depending on experience, location, and employer.

What is a variant interpretation scientist?

A Variant Interpretation Scientist is a genetics professional who analyzes and interprets genetic variants found in DNA sequencing data. Their main role is to determine whether specific genetic changes are benign, pathogenic, or of uncertain significance by integrating scientific literature, databases, and clinical information. They often work in clinical laboratories, research institutions, or biotechnology companies, contributing to genetic testing, diagnosis, and personalized medicine. Their expertise helps guide clinical decisions and advance our understanding of genetic diseases.

What are the key skills and qualifications needed to thrive as a variant interpretation scientist?

To succeed as a Variant Interpretation Scientist, you need a strong background in genetics, molecular biology, and bioinformatics, typically supported by an advanced degree in a life science field. Familiarity with genomic databases, variant annotation tools, and next-generation sequencing (NGS) platforms is essential, along with knowledge of standards like ACMG guidelines. Attention to detail, critical thinking, and effective communication are vital soft skills for collaborating with clinical teams and conveying complex findings. These competencies ensure accurate interpretation of genetic variants, supporting precise diagnoses and impactful patient care.

What are some common challenges faced by variant interpretation scientists when analyzing genetic data?

Variant Interpretation Scientists often encounter challenges such as distinguishing between benign and pathogenic variants, especially when dealing with variants of uncertain significance (VUS). Interpreting novel or rare variants can require extensive literature review and collaboration with clinicians and other scientists. Additionally, staying updated with rapidly evolving databases and guidelines is crucial for accurate interpretation. Effective communication of findings to multidisciplinary teams is also essential, as results can impact patient care and clinical decision-making.

What are popular job titles related to Variant Interpretation Scientist jobs?

For Variant Interpretation Scientist jobs, the most frequently searched job titles are:

Infographic showing various Variant Interpretation Scientist job openings in the United States as of June 2026, with employment types broken down into 34% As Needed, 33% Full Time, and 33% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $79,408 per year, or $38.2 per hour.

Clinical Genomics Scientist: Variant Interpretation & NGS

Phoenix, AZ • On-site

Phoenix Children's Hospital, Inc.
Health Care and Social Assistance • 1 - 5K employees
Learn more about Phoenix Children's Hospital, Inc.external

$80 - $100/hr

Other

Posted 7 days ago

Job description

Phoenix Children's Hospital, Inc. is looking for a Clinical Genomics Scientist to support genomic testing through variant interpretation, classification, and reporting. Responsibilities include working with clinical genomic physician leadership and ensuring high-quality genomic results through a meticulous scientific approach.

The ideal candidate holds a PhD or Master’s degree in a relevant field and has at least 3 years of experience in Clinical Genomics or Molecular Diagnostics. Additional preferred skills include proficiency with bioinformatics tools and a strong understanding of molecular genetics.

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About Phoenix Children's Hospital

Sourced by ZipRecruiter

Phoenix Children's Hospital, located in Phoenix, AZ, is a prominent establishment within the healthcare industry. Known for its commitment to pediatric healthcare, the hospital provides a vast range of services catering to the unique health needs of children. Originally founded in 1983, Phoenix Children's Hospital prides itself on being one of the largest and most respected children's hospitals in the country. Guided by its mission–"to provide hope, healing and the best healthcare for children and their families"–the hospital holds strong on its core values of family-centered care, excellence in clinical care, innovation, and stewardship.

Industry

Health care and social assistance

Company size

1,001 - 5,000 Employees

Headquarters location

Phoenix, AZ, US

Year founded

1983

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