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Upstream Process Development Mammalian Jobs (NOW HIRING)

Legend Biotech USA, Inc.

$104K - $132K/yr

Role OverviewThe Senior Scientist, Lentivirus Upstream Process Development, will be a core ... seed train optimization, mammalian cell culture (HEK293/HEK293T), large-scale transient ...

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How much do upstream process development mammalian jobs pay per hour?

As of Sep 9, 2026, the average hourly pay for upstream process development mammalian in the United States is $33.68, according to ZipRecruiter salary data. Most workers in this role earn between $27.64 and $41.35 per hour, depending on experience, location, and employer.

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Infographic showing various Upstream Process Development Mammalian job openings in the United States as of June 2026, with employment types broken down into 4% As Needed, 80% Part Time, 4% Temporary, and 12% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $70,060 per year, or $33.7 per hour.

Upstream Senior Scientist, Process Development / Wheeler Bio

Oklahoma City, OK • On-site

Plainsvc
See more jobs at Plainsvcexternal

$85K - $116K/yr

Other

Posted 22 days ago

Job description

Description

As an upstream Process Development Senior Scientist, you will support the development, optimization, and scale-up of mammalian upstream bioprocesses for the manufacture of biologic drug substances. You will contribute to the design and execution of laboratory experiments, data analysis, and technical documentation.

Key Responsibilities
  • Perform laboratory experiments to support mammalian upstream (cell culture) process development.
  • Utilize Design of Experiments (DoE) for data analysis and experimental design.
  • Assist in the optimization of upstream bioprocess parameters for yield, purity, and product quality attributes, collaborating with downstream, analytical and formulation teams.
  • Support scale-up and technology transfer of processes to manufacturing or pilot facilities based on engineering principles including oxygen transfer.
  • Work cross-functionally with analytical development, MSAT, manufacturing and quality teams to drive successful technology transfer.
  • Prepare buffers, media, and other solutions according to SOPs and protocols.
  • Operate and maintain flask and bioreactor equipment.
  • Collect, analyze, and interpret experimental data; maintain accurate lab records and electronic notebooks.
  • Present findings in internal and client meetings.
  • Author technical reports and regulatory documentation.
  • Complete Root Cause Analyses as needed, implementing corrective and preventative actions as needed.
  • Mentor junior scientists and research associates in daily activities, data trending and data analysis.
  • Follow all safety, quality, and compliance requirements.
Qualifications Education
  • Bachelor’s, master’s or PhD degree in Chemical Engineering, Biochemistry, Biotechnology, Biology, or related field.
Experience
  • 5 – 12 years of hands‑on experience in a bioprocessing or biopharmaceutical development environment (academic or industrial); some education qualifications may substitute for some years of experience.
  • Experience in a CDMO environment is required.
  • Experience with suspension mammalian cell culture and stirred tank bioreactors is required.
  • Knowledge of protein purification and analytical techniques is a plus.
Skills and Knowledge
  • Understanding of cGMP, GLP, or other regulatory standards (preferred).
  • Strong analytical and problem‑solving skills.
  • Good written and verbal communication skills.
  • Ability to work both independently and in a collaborative team environment.
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