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Salary: Per UAW starting salary effective 7/1/25 $74,692
Department: 866 - Department of Immunology and Immunotherapy
Location: Icahn Building 12th floor-1425 Madison Ave, New York, NY 10029
Department website: https://icahn.mssm.edu/about/departments-offices/immunology-immunotherapy
Laboratory website: https://profiles.mountsinai.org/louai-labanieh
Responsibilities
The Louai Labanieh Lab is seeking motivated postdocs to develop, characterize, and test novel biotechnology platforms for: i) the precise in vivo delivery of genetic cargo and ii) regulation of immune cell function. These projects are focused on making safer and more effective cell therapies (e.g., CAR-T) and gene therapies for cancer and beyond. We are an interdisciplinary lab spanning the fields of synthetic biology, immune cell engineering, protein engineering, and immunology, with an eye towards clinical translation. Postdoctoral fellows will gain extensive experience with cutting-edge methodologies in T cell engineering, gene editing, viral vector engineering, single-cell omics, and in vivo gene delivery. This is a unique opportunity for passionate scientists to develop next-generation cell and gene therapies that overcome pressing clinical challenges with the potential to provide curative therapies for patients suffering from cancer and other debilitating diseases. We aim to provide a supportive lab environment that fosters research excellence, integrity, and positivity. The Principal Investigator will work closely with trainees to help them reach their full potential and make sure they are on track to achieve their career goals.
The candidate should have a PhD and/or MD in bioengineering, immunology, cellular/molecular biology, cancer biology, or related field, and experience in wet lab research. Prior experience in cell engineering, synthetic biology, T cell biology, or protein engineering is highly desirable but not required. We encourage applications from individuals with a strong foundation in related fields who are eager to learn and contribute to our research program.
Technical duties include but are not limited to:

• Lead independent research projects, including hypothesis development, experimental design, execution, and data interpretation.
• Design and engineer novel synthetic constructs to precisely control immune cell function.
• Analyze, visualize, and interpret data
• Document and maintain raw data, analyzed data, constructs, and protocols in an organized manner and share them with others when needed
• Engage in regular meetings with the Principal Investigator for project updates, scientific discussions, and career mentorship.
• Present research findings at scientific conferences and contribute to the publication of manuscripts and grant proposals.
• Train and mentor junior lab members
• Assist in maintaining lab functions
• Perform mammalian cell culture, viral transduction, and molecular cloning
• Apply and develop methods in protein biochemistry
• Utilize advanced microscopy techniques, including confocal microscopy.
• Conduct functional assays to assess immune cell activity (e.g., cytotoxicity assays, proliferation assays, ELISA).
• Perform in vivo experiments in mouse models to evaluate the safety and efficacy of bioengineered constructs and investigate underlying biological mechanisms.
• Analyze immune cell populations by flow cytometry, RNA-seq, and ATAC-seq
• Collaborate effectively with members of the research team.
• Communicate clearly and concisely, both orally and in writing, and adhere to project deadlines.
• Maintain strict adherence to laboratory safety policies and procedures.

Qualifications
The Labanieh Lab is affiliated with the Department of Immunology and Immunotherapy, the Icahn Genomics Institute (IGI), and the Precision Immunology Institute (PrIISM). We are part of a collaborative community of bold thinkers with world renowned expertise in basic sciences and cutting-edge clinical care. The department is supported by state-of-the-art technology cores. We are located in the Icahn Building in the Upper East Side in Manhattan, one block from Central Park. The Icahn School of Medicine at Mount Sinai (ISMM) is an international leader in medical and scientific training, biomedical research, and patient care. It is the medical school for the Mount Sinai Health System, which includes seven hospital campuses, and has more than 5,000 faculty and nearly 2,000 students, residents and fellows.
In addition to submitting an application through https://careers.mountsinai.org/, candidates are encouraged to send the following directly to Dr. Labanieh (louai.labanieh@mssm.edu):

• Cover letter (indicating earliest and preferred start dates)
• Updated Curriculum Vitae or Biosketch
• Brief statement of research interests (<300 words)
• Contact information for three references

This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW.
Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf.
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