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Systems Integration Engineer Jobs in California (NOW HIRING)

ONI

Senior Systems Integration Engineer

San Diego, CA

$130K - $144K/yr

We are seeking a versatile Senior Systems Integration Engineer who thrives at the intersection of hardware, software, and biology to lead the technical realization of our next-generation biotech ...

JT4 LLC

Human Systems Integration - Engineer

Edwards, CA · On-site

$110K - $185K/yr

Candidates will perform a variety of engineering tasks in the field of aerospace human systems integration (HSI) in design, development, manufacturing, testing, installation, integration, sustainment ...

Apple

Wireless Systems Integration Engineer

Irvine, CA · On-site

$179K/yr

We have an opportunity for a forward-thinking and unusually hardworking Wireless System Engineer ... integration, design of radio calibration algorithms, chip bringup, and characterization of ...

Apple

Wireless Systems Integration Engineer

Los Angeles, CA · On-site

$179K/yr

We have an opportunity for a forward-thinking and unusually hardworking Wireless System Engineer ... integration, design of radio calibration algorithms, chip bringup, and characterization of ...

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All JobsSystems Integration Engineer JobsSystems Integration Engineer Jobs in California

Systems Integration Engineer information

See California salary details

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$155K

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How much do systems integration engineer jobs pay per year?

As of Jul 16, 2026, the average yearly pay for systems integration engineer in California is $154,986.00, according to ZipRecruiter salary data. Most workers in this role earn between $164,800.00 and $164,800.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Systems Integration Engineer, and why are they important?

To thrive as a Systems Integration Engineer, you need a strong background in computer science or engineering, experience with systems architecture, and proficiency in integrating hardware and software components. Familiarity with tools such as middleware platforms, scripting languages (like Python or Bash), and integration frameworks (such as RESTful APIs or message brokers), along with relevant certifications, is highly valued. Strong problem-solving abilities, effective communication, and teamwork are vital soft skills for managing complex projects and collaborating across departments. These skills ensure seamless system interoperability, minimize integration issues, and drive successful project outcomes.

What is the difference between Systems Integration Engineer vs Network Engineer?

AspectSystems Integration EngineerNetwork Engineer
CredentialsBachelor's in Engineering, Computer Science, or related field; certifications like Cisco CCNA, CompTIA Network+Bachelor's in Computer Science, Networking, or related; certifications like Cisco CCNA, CompTIA Network+
Work EnvironmentDesigning, testing, and implementing integrated systems across hardware and softwareDesigning, deploying, and maintaining network infrastructure and security
Industry UsageIT, telecommunications, manufacturing, aerospaceIT, telecommunications, data centers, enterprise networks

While both roles require networking knowledge and certifications, Systems Integration Engineers focus on combining various systems into cohesive solutions, whereas Network Engineers specialize in designing and managing network infrastructure. Both roles are essential in technology environments but serve different aspects of system and network integration.

What are some typical challenges Systems Integration Engineers face when working on cross-functional projects?

Systems Integration Engineers often encounter challenges when coordinating between diverse teams, such as software developers, hardware engineers, and project managers. Ensuring all components from different disciplines function together seamlessly can be complex, requiring strong communication and problem-solving skills. Additionally, managing integration timelines and troubleshooting unforeseen compatibility issues are common aspects of the role. Being proactive in identifying potential risks and maintaining organized documentation can help mitigate these challenges.

What are Systems Integration Engineers?

Systems Integration Engineers are professionals who design, implement, and manage the integration of various software and hardware systems within an organization. Their main role is to ensure that different technological components, often from different vendors, work together seamlessly to meet business requirements. This involves troubleshooting integration issues, developing custom solutions, and collaborating with other IT professionals. They play a critical role in streamlining operations and improving system efficiency.
What cities in California are hiring for Systems Integration Engineer jobs? Cities in California with the most Systems Integration Engineer job openings:
What are popular job titles related to Systems Integration Engineer jobs in CA? For Systems Integration Engineer jobs in CA, the most frequently searched job titles are:
Systems Integration Engineer jobs near you
Infographic showing various Systems Integration Engineer job openings in California as of July 2026, with employment types broken down into 92% Full Time, 4% Part Time, 1% Temporary, and 3% Contract. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $154,986 per year, or $74.5 per hour.

Senior Systems Integration Engineer

ONI

San Diego, CA

$130K - $144K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 18 days ago

Job description

 
 

At ONI, we are driven by a profound mission: to propel scientific discovery and combat diseases by granting everyone the ability to visualize, comprehend, and share the intricate microscopic details of life. Our revolutionary super resolution microscope and fluidic systems stand at the forefront of advancing cellular studies on a molecular level. 

We are seeking a versatile Senior Systems Integration Engineer who thrives at the intersection of hardware, software, and biology to lead the technical realization of our next-generation biotech platforms. 

Your role at ONI as a Senior Systems Integration Engineer 

As a Senior Systems Integration Engineer within the Fluidics Team, you will be the technical "glue" between design and production. You will not only verify that our systems work, but actively participate in the design, prototyping, and manufacturing scale-up of complex biotech hardware. This role requires a unique blend of fluid dynamic knowledge, mechanical design (CAD), automated testing (Python), and a deep understanding of manufacturing processes (injection molding, CNC machining). 

 
 
 
 
Key Responsibilities

System Integration & Verification 

  • Lead end-to-end system integration across fluidic systems, consumables, optics, and electronics. 

  • Develop system-level test strategies, integration plans, and verification protocols aligned with product requirements. 

  • Design and execute rigorous V&V protocols to identify technical issues early in the development lifecycle. 

Mechanical Design & Prototyping 

  • Design and manufacture test fixtures and prototypes using SolidWorks. 

  • Utilize 3D printing (Resin/FDM), CNC machining, and sheet metal fabrication to accelerate R&D. 

Consumables & Fluidic Systems Development 

  • Lead development of microfluidic devices and injection-molded consumables, including tooling oversight, material selection (e.g., PSA, overmolding), and biocompatibility considerations. 

Manufacturing Transfer (NPI) 

  • Drive transfer from R&D to manufacturing, ensuring designs are robust, documented and scalable.  

  • Create and maintain Work Instructions (WI), SOPs, and validation documentation (IQ/OQ/PQ). 

  • Manage Bill of Materials (BOMs) and Engineering Change processes (ECO/ECR) using PDM tools (3DXperience). 

Automation & Control 

  • Develop automated test frameworks in Python for hardware testing (e.g., leak testing, heat sealing, liquid handling). 

  • Collaborate with the Software team for firmware/software integration and version control (GitHub). 

Risk & Quality Management 

  • Maintain and manage dFMEA, pFMEA, and risk register ownership. 

  • Conduct root-cause analysis and failure investigations using HAL logs and data analysis. 

Cross-functional Leadership 

  • Work independently to source materials, manage vendors and contractors, and collaborate with Assay, Software, and Production teams to meet product launch milestones. 

Essential skills and qualifications 

  • Bachelor's degree in an engineering discipline (Mechanical, Electrical, Optical, or related field). 

  • 5+ years of experience in system integration, hardware development, or complex instrumentation.

  • Demonstrated experience in testing and integrating systems containing automated liquid handlers, fluidic consumables and high-precision instrumentation. 

  • Deep understanding of fluid dynamics as well as fluidic components, including peristaltic/syringe pumps, solenoid valves, sensors (pressure/flow), and connectors.  

  • Proficiency in 3D CAD for part/assembly design, detailed drawings, and design iteration.  

  • Experience with SolidWorks is strongly preferred, particularly for complex assemblies, production ready drawings, and Product Data Management (PDM) workflows. 

  • Proficiency in Python for test automation and data analysis (Excel/Custom scripts). 

  • Experience developing test methods and executing system-level verification and validation. 

  • Solid understanding of various manufacturing methods, specifically injection molding, assembly, and quality control (e.g., First Article Inspection). 

  • Familiarity with full product development processes (concept to launch) and rigorous technical documentation standards. 

Preferred skills and qualifications

  • Hands-on wet lab experience, with familiarity in biological workflows or assay development.  

  • Experience with embedded systems (e.g., STM32) and integration of PCB-based hardware and firmware. 

  • Knowledge of super-resolution microscopy, optics, and imaging subsystems. 

  • Working knowledge of electronics design tools (e.g., Altium Designer, KiCAD) and hands-on skills such as soldering, and custom cabling. 

  • Experience with sterilization methods (e.g., Gamma, EtO) and materials used in biomedical consumables. 

  • Familiarity with pressure-sensitive adhesives (PSA), overmolding, or microfluidic device fabrication. 

$130,000 - $144,000 a year
At ONI, we understand that a fulfilling career involves more than just challenging work - it's about enjoying a well-rounded experience. When you become a part of our team, you not only contribute to groundbreaking research but also enjoy a range of benefits designed to enhance your life both inside and outside the workplace. 

As an equal opportunity employer, we prioritize fairness and respect, ensuring every team member thrives regardless of their background. But that's not all - our perks include:

Competitive Compensation We recognize and reward your talent. Enjoy a competitive salary that reflects your expertise and contributions, ensuring your hard work is recognized.
Flex PTO plus 11 federal holidays and 4 dedicated wellbeing days.
Gym Access via ARE: Sorrento Valley, Torrey Pines, and UTC
401K via ADP
Life Insurance
Medical
Dental
Vision
Perks at Work: Enjoy exclusive discounts and deals through our perks at work program, adding value to your everyday life.

If you are driven by innovation, eager to make a significant impact in the realm of scientific and medical research, and possess the skills and passion we are looking for, we invite you to apply and be a part of our mission to improve our understanding of the details of life. 
We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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