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System Manager Jobs in West Roxbury, MA (NOW HIRING)

Boston Red Sox

Financial Systems Manager

Boston, MA · On-site

$115K - $135K/yr

The Finance Systems Manager will be the primary owner and administrator of the Finance department ... System Administration * Serve as the lead administrator for Oracle NetSuite and associated modules ...

Boston Red Sox

Financial Systems Manager

Boston, MA

$115K - $135K/yr

The Finance Systems Manager will be the primary owner and administrator of the Finance department ... System Administration * Serve as the lead administrator for Oracle NetSuite and associated modules ...

Mwe

Accounting & Finance Systems Manager

Boston, MA

Deliver end-to-end system enhancements and projects, including intake, design, configuration, testing, deployment, and adoption, coordinating with internal partners and vendors as needed * Manage day ...

Vicor Corporation

Manager Financial Systems

Andover, MA · On-site

$130K - $160K/yr

Manage third-party consulting resources, system integrators, and software vendors * Develop project plans, resource requirements, budgets, timelines, risk mitigation plans, and executive-level status ...

Vicor Corporation

Manager Financial Systems

Andover, MA

$130K - $160K/yr

Manage third-party consulting resources, system integrators, and software vendors * Develop project plans, resource requirements, budgets, timelines, risk mitigation plans, and executive-level status ...

Polygon US

Systems & Data Manager

Andover, MA · On-site

$80 - $110K/hr

Oversight and ownership of system functionality as modified, including operational support of tasks, projects, workflows, and business process improvements. * Partner with the IT Manager on ...

Polygon US

Systems & Data Manager

North Andover, MA

$80 - $110K/hr

Oversight and ownership of system functionality as modified, including operational support of tasks, projects, workflows, and business process improvements. * Partner with the IT Manager on ...

Vicor Corporation

Manager Financial Systems

Andover, MA

$130K - $160K/yr

Manage third-party consulting resources, system integrators, and software vendors * Develop project plans, resource requirements, budgets, timelines, risk mitigation plans, and executive-level status ...

Editas Medicine

Manager, Quality Systems

Cambridge, MA · On-site

$135K - $150K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Support the management and administration of the electronic document management system (Veeva QualityDocs), the electronic quality management system (Veeva QMS), and the electronic learning ...

Editas Medicine

Manager, Quality Systems

Cambridge, MA · On-site

$135K - $150K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Support the management and administration of the electronic document management system (Veeva QualityDocs), the electronic quality management system (Veeva QMS), and the electronic learning ...

Xinnovit

UNIX-Linux System Admin

Waltham, MA

Test Manager MD) To provide a return on investment to shareholders. To promote employee development ... Operating System Configuration/Tuning Must possess a very good hands-on routine Linux/RedHat ...

Jobtailor

Director, HRIS - SAP Success Factors

Milford, MA · On-site

$110 - $160/hr

Prior leadership experience managing a global HRIS team. * Strong knowledge of HR processes, workforce planning, compensation, performance management, and talent acquisition. * Experience leading HRI ...

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All JobsSystem JobsSystem Manager JobsSystem Manager Jobs in West Roxbury, MA

System Manager information

See West Roxbury, MA salary details

$47.1K

$104.5K

$156.7K

How much do system manager jobs pay per year?

As of Aug 17, 2026, the average yearly pay for system manager in West Roxbury, MA is $104,546.00, according to ZipRecruiter salary data. Most workers in this role earn between $78,900.00 and $128,000.00 per year, depending on experience, location, and employer.

What are some common challenges a system manager faces when overseeing IT infrastructure across multiple departments?

A System Manager often encounters challenges in ensuring seamless integration and compatibility among various systems used by different departments. Balancing the unique needs of each department while maintaining security and compliance standards can be complex. Additionally, System Managers must proactively address potential system downtimes and coordinate with cross-functional teams to implement updates or troubleshoot issues. Effective communication and strong organizational skills are essential to manage these challenges and support smooth business operations.

What are the key skills and qualifications needed to thrive as a system manager, and why are they important?

To thrive as a System Manager, you need a solid background in IT systems administration, network management, and computer science, often supported by a relevant degree and professional certifications like CompTIA, Microsoft, or Cisco. Familiarity with operating systems (such as Windows Server, Linux), virtualization tools, and network security platforms is typically required. Strong problem-solving, leadership, and communication skills set outstanding system managers apart. These competencies are crucial for maintaining secure, efficient IT environments and supporting organizational operations.

What is the difference between System Manager vs Network Administrator?

AspectSystem ManagerNetwork Administrator
CertificationsCompTIA Security+, Microsoft Certified: Windows Server FundamentalsCompTIA Network+, Cisco CCNA
Work EnvironmentOversees entire IT systems, including hardware, software, and security across organizationsFocuses on managing and maintaining network infrastructure and connectivity
Employer & Industry UsageUsed in various industries for IT system oversightPrimarily in organizations with complex network needs

The System Manager typically oversees the entire IT infrastructure, including networks, servers, and security, requiring broader technical knowledge. In contrast, the Network Administrator specializes in managing network-specific components like routers, switches, and network security. Both roles are essential in IT operations but focus on different areas within the technology environment.

How much do system managers make in the US?

System managers in the US typically earn a median annual salary of around $100,000, with salaries ranging from approximately $70,000 to $130,000 depending on experience, location, and industry. Higher salaries are often associated with certifications, advanced skills, and management responsibilities.

What does a system manager do?

A system manager oversees the installation, configuration, and maintenance of computer systems and networks within an organization. They ensure system security, troubleshoot issues, and optimize performance, often using tools like monitoring software and following industry best practices. Strong technical skills and certifications such as CompTIA or Microsoft are commonly required.

What cities near West Roxbury, MA are hiring for System Manager jobs?

Cities near West Roxbury, MA with the most System Manager job openings:

System Manager jobs near you
Infographic showing various System Manager job openings in West Roxbury, MA as of August 2026, with employment types broken down into 86% Full Time, 12% Part Time, and 2% Contract. Highlights an 86% Physical, 2% Hybrid, and 12% Remote job distribution, with an average salary of $104,546 per year, or $50.3 per hour.

Quality Management System Lead

Tango Therapeutics

Boston, MA • On-site

$151K - $226K/yr

Full-time

Posted 24 days ago

Job description

Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
Own and continuously improve the QMS framework to ensure processes, document control, training, and quality records support consistent compliance across functions and regions.
Your Role:
  • Define and maintain QMS structure: policies, SOPs, work instructions, templates, and governance
  • Ensure harmonization across GxP domains (GMP/GLP/GCP) and alignment with applicable regulations/standards
  • Oversee document lifecycle management (authoring standards, review/approval, periodic review, archival)
  • Ensure change control processes exist and are followed (QMS changes and cross-functional change impacts)
  • Oversee GxP training framework (curricula, assignment rules, effectiveness checks, compliance reporting)
  • Partner with functional owners to define role-based training requirements
  • Ensure QMS records are complete, traceable, audit-ready, and meet data integrity principles
  • Establish metrics and trending for QMS health (cycle time, overdue items, training compliance)
  • Lead QMS simplification/optimization, including CAPA prevention initiatives based on trending and learnings
  • Prepare Quality Management Review packages: KPIs, risks, audit outcomes, CAPA effectiveness, and improvement plans

What You Bring:
  • Bachelor's degree in Life Sciences, Quality, or related discipline (required)
  • Quality-related certification preferred (e.g., ASQ, ISO Lead Auditor, Quality Systems)
  • Training in electronic QMS platforms advantageous
  • 8-12 years in Quality Assurance or Compliance
  • Hands-on experience managing QMS in regulated GxP environments
  • Experience supporting QMS-related inspections and audits
  • QMS design, lifecycle management, and governance
  • GxP training systems and compliance tracking
  • Data integrity and document control standards
  • Process-oriented, structured, and detail focused
  • Strong communication and training skills
  • Ability to simplify complex processes and drive alignment

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Salary range
$151,200-$226,800 USD

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