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Staff Software Engineer Principal Engineer Jobs

Vibehackers

Staff Software Engineer

Chicago, IL · On-site

$150 - $200/hr

Role Staff Software Engineer located at John Deere World Headquarters in Chicago, IL. Lead ... and principal engineers. * Provide full‑stack leadership across React/Redux front ends, Java ...

GDIT

Principal Software Engineer

San Antonio, TX

$121K - $163K/yr

The Software Engineer Principal must have experience with: * Providing technical leadership and ... staff) on secure system design, deployment, and operation. This includes mentoring junior engineers ...

Victory

Staff Software Engineer

Austin, TX · On-site

About the Staff Software Engineer position We are looking for a Staff Software Engineer who will be a key member of the Engineering team. You will be architecting, implementing and maintaining the ...

Victory

Staff Software Engineer

Austin, TX · On-site

About the Staff Software Engineer position We are looking for a Staff Software Engineer who will be a key member of the Engineering team. You will be architecting, implementing and maintaining the ...

Victory

Staff Software Engineer

Austin, TX · On-site

About the Staff Software Engineer position We are looking for a Staff Software Engineer who will be a key member of the Engineering team. You will be architecting, implementing and maintaining the ...

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Staff Software Engineer Principal Engineer information

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How much do staff software engineer principal engineer jobs pay per year?

As of Sep 9, 2026, the average yearly pay for staff software engineer principal engineer in the United States is $161,148.00, according to ZipRecruiter salary data. Most workers in this role earn between $134,500.00 and $190,500.00 per year, depending on experience, location, and employer.

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Staff Software Engineer / Technical Lead

San Francisco, CA • On-site

Tamarind Bio
See more jobs at Tamarind Bioexternal

$150 - $200/hr

Other

Re-posted 25 days ago

Job description

About Tamarind Bio

We enable any scientist to access AI-powered drug discovery. Thousands of scientists from large pharma companies, top biotechs, and academic institutions use Tamarind to design protein drugs, improve industrial enzymes, and create cutting edge molecules that weren’t feasible until now.

New AI models are quickly eclipsing physics-based tools in computational drug discovery. Scientists often struggle to fine-tune, deploy, and scale these models, leaving breakthroughs on the table. Tamarind provides a simple interface to the vast array of tools being released daily.

Staff Software Engineer / Technical Lead

We're hiring a Staff Software Engineer to provide technical leadership across our engineering team as we continue to scale the platform behind Tamarind.

Today, our engineering team consists primarily of early and mid-career engineers. As the complexity of our systems and customer requirements continues to grow, we're looking for someone who can help guide technical decision-making, mentor engineers, and drive architectural discussions across the organization.

This is not an engineering management role.

We're looking for a hands‑on technical leader who enjoys writing code, reviewing designs, solving difficult engineering problems, and helping other engineers grow. You'll work closely with the CTO to shape technical direction while remaining deeply involved in execution.

The role spans architecture, infrastructure, product development, code reviews, technical mentorship, and engineering best practices.

What You'll Do
  • Partner with the CTO on architecture, technical planning, and major engineering initiatives
  • Provide technical guidance across a team of 7-8 engineers
  • Lead design reviews and architectural discussions
  • Help engineers navigate complex technical challenges
  • Contribute directly to the codebase across infrastructure, backend services, APIs, and product development
  • Review code and provide feedback on implementation approaches
  • Identify opportunities to improve reliability, scalability, performance, and developer productivity
  • Support technical decision-making across new products and platform capabilities
  • Work closely with customers and internal stakeholders to understand requirements and translate them into practical solutions
  • Help establish engineering standards as the team continues to grow
Week in the Life
  • Collaborate with the CTO on technical priorities and architectural decisions
  • Review designs and provide guidance on implementation approaches
  • Build and operate services across infrastructure, ML systems, APIs, and customer‑facing applications
  • Participate in code reviews and technical discussions
  • Help unblock engineers working through difficult technical problems
  • Work directly with customers to understand requirements and gather feedback
  • Balance hands‑on engineering work with technical leadership responsibilities
Ideal Qualifications
  • 7+ years of software engineering experience
  • Experience serving as a senior technical contributor, staff engineer, principal engineer, or technical lead
  • Strong software architecture and distributed systems experience
  • Experience building and operating production infrastructure and cloud services
  • AWS experience (EC2, S3, DynamoDB, Docker, etc.)
  • Ability to mentor engineers and provide technical guidance across multiple projects
  • Strong communication skills and sound engineering judgment
  • Comfort operating in an early‑stage startup environment
  • Willingness to work onsite in San Francisco
Technology

Our technology sits at the intersection of DevOps, MLOps, and Computational Biology. We support workloads ranging from large‑scale ML inference and model deployment to workflow orchestration across research, infrastructure, and scientific computing environments.

The role requires someone who enjoys moving between architecture, implementation, operations, and mentorship while helping a growing engineering team tackle increasingly complex technical challenges.

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