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Sr Python Engineer Jobs in Missouri (NOW HIRING)

This is a senior engineering opportunity at the intersection of software development and production ... The role spans asynchronous Python, network orchestration, routing automation, cloud interconnects ...

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

As a Senior Software Engineer in Information Security, you will deliver advanced support and develop enterprise security services by analyzing systems and designing robust security solutions. This ...

As a Senior Software Engineer in Information Security, you will deliver advanced support and develop enterprise security services by analyzing systems and designing robust security solutions. This ...

As a Senior Software Engineer in Information Security, you will deliver advanced support and develop enterprise security services by analyzing systems and designing robust security solutions. This ...

Design and implement backend services and APIs using Python (FastAPI, Flask, or similar frameworks ... Stack Engineer or Software Developer building enterprise-grade web applications. * Strong ...

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

Senior AI Engineer

O Fallon, MO · Hybrid

$97K - $134K/yr

Title and Summary Senior AI Engineer Mastercard's Business & Market Insights (B&MI) group empowers ... Develop high-performance Python backend services for LLM inference orchestration, async job ...

As a Senior Software Engineer in Information Security, you will design, develop, and support ... Python, Java, or similar. * Experience developing and consuming REST APIs and enterprise ...

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

As a Senior Software Engineer in Information Security, you will design, develop, and support ... Python, Java, or similar. * Experience developing and consuming REST APIs and enterprise ...

Senior AI Engineer

O Fallon, MO · On-site

$97K - $134K/yr

Title and Summary Senior AI Engineer Mastercard's Business & Market Insights (B&MI) group empowers ... Python backend services for LLM inference orchestration, async job handling, streaming responses ...

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Sr Python Engineer information

What does a Sr Python Engineer do?

A Sr Python Engineer is an experienced software developer who specializes in designing, developing, and maintaining applications using the Python programming language. They often lead projects, mentor junior engineers, and work on complex problems that require deep technical expertise. Their responsibilities may include writing efficient code, optimizing performance, integrating with APIs or databases, and ensuring the overall quality of software solutions. Additionally, they may collaborate with cross-functional teams to deliver robust and scalable applications.

What are the key skills and qualifications needed to thrive as a Sr Python Engineer?

To thrive as a Sr Python Engineer, you need advanced proficiency in Python programming, strong knowledge of software design patterns, and experience with scalable application development, often supported by a degree in computer science or related field. Familiarity with frameworks like Django or Flask, version control systems such as Git, and cloud platforms like AWS or Azure is typically required, with certifications in cloud or Python development considered a plus. Excellent problem-solving abilities, strong communication, and leadership skills help you collaborate effectively and mentor junior engineers. These competencies are critical for delivering robust, efficient solutions and driving technical excellence within development teams.

What are some common challenges Sr Python Engineers face when working on large-scale applications?

Sr Python Engineers often encounter challenges related to maintaining code quality and scalability as applications grow. Managing dependencies, ensuring optimal performance, and coordinating with cross-functional teams can be complex, especially in distributed systems. Additionally, integrating new technologies or frameworks while maintaining backward compatibility requires careful planning and communication. Proactive code reviews, clear documentation, and collaborative problem-solving are essential to overcoming these challenges.

What is the difference between Sr Python Engineer vs Python Developer?

AspectSr Python EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in Python, often some leadership skillsBachelor's degree in CS or related field, strong Python skills, often less emphasis on leadership
Work EnvironmentTeam lead, project architect, involved in system design and optimizationCode writing, feature development, bug fixing
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects

While both roles require strong Python skills, Sr Python Engineers typically have more experience, leadership responsibilities, and involvement in system architecture, whereas Python Developers focus more on coding and feature implementation.

What cities in Missouri are hiring for Sr Python Engineer jobs?

Cities in Missouri with the most Sr Python Engineer job openings:

Infographic showing various Sr Python Engineer job openings in Missouri as of August 2026, with employment types broken down into 94% Full Time, 3% Part Time, and 3% Contract. Highlights an 85% Physical, 5% Hybrid, and 10% Remote job distribution.

Senior Python Developer

Saint Louis, MO • On-site

Noor Staffing Group
Recruiting and Staffing Services • 201 - 500 employees

$150K - $190K/yr

Full-time

Re-posted 19 days ago


Job description

Position: Senior Python Developer

Location: St. Louis area (onsite)

Salary: $150,000 - $190,000 DOE + full benefits

What you need for this position:

Hold a TS/SCI Clearance

Experience with Python or similar backend programming language (Java, Golang, node.js)

Excellent communication and team skills

5+ years of Software Development experience