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Sr Python Engineer Jobs in Missouri (NOW HIRING)

$5.0K - $6.5K/mo

Our partner is looking for a Senior Python Engineer based in Netherlands. This fully remote opportunity is designed for an experienced Python engineer passionate about building scalable data ...

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Description SR. PYTHON DEVELOPER This position is based out of our St Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated ...

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

Description SR. PYTHON DEVELOPER This position is based out of our S t Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated ...

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

The Senior Python Developer is responsible for designing, developing, and maintaining complex Python applications and systems while providing technical leadership and mentoring to team members.

Python Senior Software Engineer

Cassville, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are seeking a Senior Software Engineer with information security expertise to help design and ... Expert skills in programming languages such as Java or Python and in interfacing with a backend ...

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are seeking a Senior Software Engineer with information security expertise to help design and ... Expert skills in programming languages such as Java or Python and in interfacing with a backend ...

Python Senior Software Engineer

Anderson, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are seeking a Senior Software Engineer with information security expertise to help design and ... Expert skills in programming languages such as Java or Python and in interfacing with a backend ...

GenAI Python Systems Engineer -Senior Manager

Saint Louis, MO · On-site

$124K - $280K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

... Level Senior Manager & Summary At PwC, our people in data and analytics engineering focus on ... is a plus - Proficient in Python and structured/unstructured data - Proficient in SQL and ...

GenAI Python Systems Engineer -Senior Manager

Kansas City, MO · On-site

$124K - $280K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

... Level Senior Manager & Summary At PwC, our people in data and analytics engineering focus on ... is a plus - Proficient in Python and structured/unstructured data - Proficient in SQL and ...

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

Python Senior Software Engineer

Anderson, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

Python Senior Software Engineer

Cassville, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

$38.75 - $53.50/hr

This role is an opportunity for a senior software engineer to build and support enterprise-grade applications using .NET Core and Python. You will focus on backend and web application development ...

$94K - $124K/yr

We are seeking a Senior Geospatial Machine Learning Engineer to develop advanced AI solutions that ... Develop new geospatial intelligence products using Python-based geospatial libraries, machine ...

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Showing results 1-20

Sr Python Engineer information

What does a Sr Python Engineer do?

A Sr Python Engineer is an experienced software developer who specializes in designing, developing, and maintaining applications using the Python programming language. They often lead projects, mentor junior engineers, and work on complex problems that require deep technical expertise. Their responsibilities may include writing efficient code, optimizing performance, integrating with APIs or databases, and ensuring the overall quality of software solutions. Additionally, they may collaborate with cross-functional teams to deliver robust and scalable applications.

What are the key skills and qualifications needed to thrive as a Sr Python Engineer?

To thrive as a Sr Python Engineer, you need advanced proficiency in Python programming, strong knowledge of software design patterns, and experience with scalable application development, often supported by a degree in computer science or related field. Familiarity with frameworks like Django or Flask, version control systems such as Git, and cloud platforms like AWS or Azure is typically required, with certifications in cloud or Python development considered a plus. Excellent problem-solving abilities, strong communication, and leadership skills help you collaborate effectively and mentor junior engineers. These competencies are critical for delivering robust, efficient solutions and driving technical excellence within development teams.

What is the difference between Sr Python Engineer vs Python Developer?

AspectSr Python EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in Python, often some leadership skillsBachelor's degree in CS or related field, strong Python skills, often less emphasis on leadership
Work EnvironmentTeam lead, project architect, involved in system design and optimizationCode writing, feature development, bug fixing
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects

While both roles require strong Python skills, Sr Python Engineers typically have more experience, leadership responsibilities, and involvement in system architecture, whereas Python Developers focus more on coding and feature implementation.

What are some common challenges Sr Python Engineers face when working on large-scale applications?

Sr Python Engineers often encounter challenges related to maintaining code quality and scalability as applications grow. Managing dependencies, ensuring optimal performance, and coordinating with cross-functional teams can be complex, especially in distributed systems. Additionally, integrating new technologies or frameworks while maintaining backward compatibility requires careful planning and communication. Proactive code reviews, clear documentation, and collaborative problem-solving are essential to overcoming these challenges.

What are popular job titles related to Sr Python Engineer jobs in Missouri?

For Sr Python Engineer jobs in Missouri, the most frequently searched job titles are:

What cities in Missouri are hiring for Sr Python Engineer jobs?

Cities in Missouri with the most Sr Python Engineer job openings:

Infographic showing various Sr Python Engineer job openings in Missouri as of August 2026, with employment types broken down into 93% Full Time, 2% Part Time, and 5% Contract. Highlights an 86% Physical, 5% Hybrid, and 9% Remote job distribution.

$5.0K - $6.5K/mo

Full-time

Posted 9 days ago


Job description

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Senior Python Engineer based in Netherlands.

This fully remote opportunity is designed for an experienced Python engineer passionate about building scalable data platforms and solving complex backend challenges. In this role, you will contribute to the development and improvement of high-volume data ingestion systems that power critical business insights. You will work with large-scale data pipelines, distributed systems, and modern engineering practices while collaborating with a highly skilled international technology team. The position offers the opportunity to take ownership of impactful technical projects, improve platform reliability, and influence architectural decisions. You will play a key role in transforming complex data sources into reliable, actionable intelligence for global users.

Accountabilities
  • Develop and maintain robust Python-based solutions for large-scale data ingestion and backend systems.
  • Build, improve, and maintain data collection processes, including web scrapers and automated data pipelines.
  • Enhance platform performance, reliability, observability, and overall data quality.
  • Conduct technical research and investigations to solve complex engineering challenges.
  • Take ownership of architectural and conceptual components, including reliability, quality assurance processes, and automation initiatives.
  • Collaborate with engineering teams through code reviews, technical discussions, and cross-functional initiatives.
  • Analyze existing systems, reduce technical debt, and improve codebase maintainability.
  • Make data-driven technical decisions through exploratory data analysis and evaluation of system performance.
  • Contribute to scalable solutions using modern backend technologies, distributed systems, and event-driven architectures.
Requirements
  • Strong professional experience developing backend systems with advanced Python and SQL.
  • Experience working with large-scale data processing, distributed systems, and high-load environments.
  • Knowledge of event-driven architectures and message queue technologies such as RabbitMQ or Kafka.
  • Ability to investigate technical challenges, analyze data, and make informed engineering decisions.
  • Experience building reliable, maintainable software with a strong focus on quality and scalability.
  • Strong ownership mindset with the ability to manage projects independently and deliver impactful solutions.
  • Excellent communication skills, with the ability to explain complex technical concepts to both technical and non-technical stakeholders.
  • Comfortable working in a fast-paced environment with changing priorities and evolving requirements.
  • Experience with data products, Big Data environments, BI, analytics, or machine learning teams is considered an advantage.
  • Familiarity with technologies such as PostgreSQL, Redis, Puppeteer, Playwright, Selenium, Pandas, NumPy, or Scikit-learn is a plus.
Benefits
  • Fully remote position based in Europe.
  • Competitive compensation ranging from approximately $5,000 to $6,500 per month, depending on experience.
  • Opportunity to work on large-scale data systems supporting global business intelligence products.
  • High level of ownership and autonomy within an experienced technology team.
  • Exposure to advanced technologies in data engineering, automation, and machine learning.
  • Collaborative international environment with opportunities for knowledge sharing and professional growth.
  • Opportunity to contribute to impactful products used by leading organizations worldwide.
  • Flexible remote working structure with collaboration across European time zones.
How Jobgether works:
We use an AI-powered matching process to ensure your application is reviewed quickly, objectively, and fairly against the role's core requirements. Our system identifies the top-fitting candidates, and this shortlist is then shared directly with the hiring company. The final decision and next steps (interviews, assessments) are managed by their internal team.
We appreciate your interest and wish you the best!
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