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Sr Python Engineer Jobs in Saint Louis, MO (NOW HIRING)

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

Description SR. PYTHON DEVELOPER This position is based out of our St Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated ...

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

Description SR. PYTHON DEVELOPER This position is based out of our S t Louis, MO office About ArchKey ArchKey is one of the nation's largest privately held specialty trade installation and integrated ...

Senior Python Developer

Fenton, MO · On-site

$116K - $156K/yr

The Senior Python Developer is responsible for designing, developing, and maintaining complex Python applications and systems while providing technical leadership and mentoring to team members.

Senior AI Engineer

O Fallon, MO · Hybrid

$97K - $134K/yr

Title and Summary Senior AI Engineer Mastercard's Business & Market Insights (B&MI) group empowers ... Develop high-performance Python backend services for LLM inference orchestration, async job ...

Senior AI Engineer

O Fallon, MO · On-site

$97K - $134K/yr

Title and Summary Senior AI Engineer Mastercard's Business & Market Insights (B&MI) group empowers ... Python backend services for LLM inference orchestration, async job handling, streaming responses ...

Sr. Elastic Engineer

Scott Air Force Base, IL · On-site

$110K - $151K/yr

Sr. Elastic Engineer (Scott AFB) We are seeking a Sr. Elastic Engineer to join our clients Federal ... integrations (Python, PowerShell, Bash, etc.) to streamline operations, data processing, and ...

Sr. Elastic Engineer

Scott Air Force Base, IL · On-site

$100K - $138K/yr

ECS is seeking a Sr. Elastic Engineer to work in our Scott AFB, IL office. Are you passionate about ... Write scripts, automation, and integrations (Python, PowerShell, Bash, etc.) to streamline ...

Senior AI/ML Engineer

Saint Louis, MO · On-site

$99K - $136K/yr

Role:-Senior AI/ML Engineer Location: St. Louis, MO (Locals only) Duration:- Long term We are ... Python code with error handling, logging, observability, and unit tests - Participate in code ...

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Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

Title and Summary Senior Software Engineer Who is Mastercard? Mastercard is a global technology ... Strict Must-Haves (Non-Negotiable) Python - Proven experience building and operationalizing ...

Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

Title and Summary Senior Software Engineer Who is Mastercard? Mastercard is a global technology ... Strict Must-Haves (Non-Negotiable) • Python - Proven experience building and operationalizing ...

Sr. Elastic Engineer

Scott Air Force Base, IL · On-site

$110K - $151K/yr

We are seeking a Sr. Elastic Engineer to join our Professional team. The ideal candidate has hands ... Write scripts, automation, and integrations (Python, PowerShell, Bash, etc.) to streamline ...

You will leverage senior-level Python programming skills to build production-ready tools, automate manual processes, and develop reusable analytic capabilities. Your work will include designing ...

Senior Network Software Engineer

Shiloh, IL · On-site

$96K - $132K/yr

The Senior Network Software Engineer will support the development and release of new software tools ... Design, develop, document, test and release software written in Python, XML, and other languages ...

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Showing results 1-20

Sr Python Engineer information

See Saint Louis, MO salary details

$22.4K

$136.1K

$196.9K

How much do sr python engineer jobs pay per year?

As of Aug 16, 2026, the average yearly pay for sr python engineer in Saint Louis, MO is $136,084.00, according to ZipRecruiter salary data. Most workers in this role earn between $107,400.00 and $159,900.00 per year, depending on experience, location, and employer.

What does a Sr Python Engineer do?

A Sr Python Engineer is an experienced software developer who specializes in designing, developing, and maintaining applications using the Python programming language. They often lead projects, mentor junior engineers, and work on complex problems that require deep technical expertise. Their responsibilities may include writing efficient code, optimizing performance, integrating with APIs or databases, and ensuring the overall quality of software solutions. Additionally, they may collaborate with cross-functional teams to deliver robust and scalable applications.

What are the key skills and qualifications needed to thrive as a Sr Python Engineer?

To thrive as a Sr Python Engineer, you need advanced proficiency in Python programming, strong knowledge of software design patterns, and experience with scalable application development, often supported by a degree in computer science or related field. Familiarity with frameworks like Django or Flask, version control systems such as Git, and cloud platforms like AWS or Azure is typically required, with certifications in cloud or Python development considered a plus. Excellent problem-solving abilities, strong communication, and leadership skills help you collaborate effectively and mentor junior engineers. These competencies are critical for delivering robust, efficient solutions and driving technical excellence within development teams.

What is the difference between Sr Python Engineer vs Python Developer?

AspectSr Python EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in Python, often some leadership skillsBachelor's degree in CS or related field, strong Python skills, often less emphasis on leadership
Work EnvironmentTeam lead, project architect, involved in system design and optimizationCode writing, feature development, bug fixing
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects

While both roles require strong Python skills, Sr Python Engineers typically have more experience, leadership responsibilities, and involvement in system architecture, whereas Python Developers focus more on coding and feature implementation.

What are some common challenges Sr Python Engineers face when working on large-scale applications?

Sr Python Engineers often encounter challenges related to maintaining code quality and scalability as applications grow. Managing dependencies, ensuring optimal performance, and coordinating with cross-functional teams can be complex, especially in distributed systems. Additionally, integrating new technologies or frameworks while maintaining backward compatibility requires careful planning and communication. Proactive code reviews, clear documentation, and collaborative problem-solving are essential to overcoming these challenges.

What are popular job titles related to Sr Python Engineer jobs in Saint Louis, MO?

For Sr Python Engineer jobs in Saint Louis, MO, the most frequently searched job titles are:

What job categories do people searching Sr Python Engineer jobs in Saint Louis, MO look for?

The top searched job categories for Sr Python Engineer jobs in Saint Louis, MO are:

What cities near Saint Louis, MO are hiring for Sr Python Engineer jobs?

Cities near Saint Louis, MO with the most Sr Python Engineer job openings:

Infographic showing various Sr Python Engineer job openings in Saint Louis, MO as of August 2026, with employment types broken down into 73% Full Time, 22% Part Time, and 5% Contract. Highlights an 86% Physical, 5% Hybrid, and 9% Remote job distribution, with an average salary of $136,084 per year, or $65.4 per hour.

$150K - $190K/yr

Full-time

Re-posted 25 days ago


Job description

Position: Senior Python Developer

Location: St. Louis area (onsite)

Salary: $150,000 - $190,000 DOE + full benefits

What you need for this position:

Hold a TS/SCI Clearance

Experience with Python or similar backend programming language (Java, Golang, node.js)

Excellent communication and team skills

5+ years of Software Development experience