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Sr Python Engineer Jobs in Saint Louis, MO (NOW HIRING)

GRVTY

Senior Data Scientist

Saint Louis, MO · On-site

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

You will leverage senior-level Python programming skills to build production-ready tools, automate manual processes, and develop reusable analytic capabilities. Your work will include designing ...

EmergencyMD

Senior Electrical Hardware Engineer

Saint Louis, MO · On-site

$100 - $140/hr

  • Medical

  • Dental

  • Vision

  • Retirement

Proficiency in Python for hardware automation and data collection CORE RESPONSIBILITIES Our Senior Electrical Engineer is responsible for designing PCBs, testing functionality, and fixing any issues ...

GRVTY

Senior Data Scientist

Saint Louis, MO

You will leverage senior-level Python programming skills to build production-ready tools, automate manual processes, and develop reusable analytic capabilities. Your work will include designing ...

Arka Infotech Inc

Sr. Scala Developer

Saint Louis, MO · On-site

$53 - $70/hr

Louis, Missouri 08-03-2015 Senior Scala Developer w/hands-on experience writing Scala architecture on OS X and AWS models -- experience coding in Clojure, Java, and/or Python also a plus. Client is ...

Intellectix

Senior Storage Engineer

Arnold, MO · On-site

Senior Storage Engineer Location: Arnold, MO (On Customer Site) Clearance: TS/SCI Citizenship: US ... PowerShell/Python scripting experience. * Experience leveraging scripts to audit and enforce ...

Intellectix

Senior Storage Engineer

Arnold, MO · On-site

Senior Storage Engineer Location: Arnold, MO (On Customer Site) Clearance: TS/SCI Citizenship: US ... PowerShell/Python scripting experience. * Experience leveraging scripts to audit and enforce ...

GDIT

Senior DevOps Engineer

Saint Louis, MO · On-site

$126K - $162K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

... ENGINEER WILL MAKE AN IMPACT A Senior DevOps Engineer will drive faster, more reliable software ... Comfortable writing Python and BASH to create systems tooling * Ability to contribute code updates ...

GCyber

Senior Network Engineer

Scott Air Force Base, IL · On-site

$100K - $137K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Senior Network Engineer is responsible for managing and maintaining network availability ... Python against network APIs, GitLab CI, and EVE-NG or a similar lab emulation tool. * Experience ...

Biomerieux

Sr. Software Engineer

Hazelwood, MO · On-site

$113K - $149K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

bioMérieux

Sr. Software Engineer

Hazelwood, MO · On-site

$115K - $152K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

bioMerieux

Sr. Software Engineer

Hazelwood, MO · On-site

$115K - $152K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

Biomerieux

Sr. Software Engineer

Hazelwood, MO · On-site

$113K - $149K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

Biomerieux

Sr. Software Engineer

Hazelwood, MO · On-site

$113K - $149K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

BioFire Diagnostics

Sr. Software Engineer

Hazelwood, MO

$115K - $152K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

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Showing results 21-40

All JobsSr Python Engineer JobsSr Python Engineer Jobs in Saint Louis, MO

Sr Python Engineer information

See Saint Louis, MO salary details

$22.4K

$136.1K

$196.9K

How much do sr python engineer jobs pay per year?

As of Aug 16, 2026, the average yearly pay for sr python engineer in Saint Louis, MO is $136,084.00, according to ZipRecruiter salary data. Most workers in this role earn between $107,400.00 and $159,900.00 per year, depending on experience, location, and employer.

What does a Sr Python Engineer do?

A Sr Python Engineer is an experienced software developer who specializes in designing, developing, and maintaining applications using the Python programming language. They often lead projects, mentor junior engineers, and work on complex problems that require deep technical expertise. Their responsibilities may include writing efficient code, optimizing performance, integrating with APIs or databases, and ensuring the overall quality of software solutions. Additionally, they may collaborate with cross-functional teams to deliver robust and scalable applications.

What are the key skills and qualifications needed to thrive as a Sr Python Engineer?

To thrive as a Sr Python Engineer, you need advanced proficiency in Python programming, strong knowledge of software design patterns, and experience with scalable application development, often supported by a degree in computer science or related field. Familiarity with frameworks like Django or Flask, version control systems such as Git, and cloud platforms like AWS or Azure is typically required, with certifications in cloud or Python development considered a plus. Excellent problem-solving abilities, strong communication, and leadership skills help you collaborate effectively and mentor junior engineers. These competencies are critical for delivering robust, efficient solutions and driving technical excellence within development teams.

What is the difference between Sr Python Engineer vs Python Developer?

AspectSr Python EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in Python, often some leadership skillsBachelor's degree in CS or related field, strong Python skills, often less emphasis on leadership
Work EnvironmentTeam lead, project architect, involved in system design and optimizationCode writing, feature development, bug fixing
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects

While both roles require strong Python skills, Sr Python Engineers typically have more experience, leadership responsibilities, and involvement in system architecture, whereas Python Developers focus more on coding and feature implementation.

What are some common challenges Sr Python Engineers face when working on large-scale applications?

Sr Python Engineers often encounter challenges related to maintaining code quality and scalability as applications grow. Managing dependencies, ensuring optimal performance, and coordinating with cross-functional teams can be complex, especially in distributed systems. Additionally, integrating new technologies or frameworks while maintaining backward compatibility requires careful planning and communication. Proactive code reviews, clear documentation, and collaborative problem-solving are essential to overcoming these challenges.

What are popular job titles related to Sr Python Engineer jobs in Saint Louis, MO?

For Sr Python Engineer jobs in Saint Louis, MO, the most frequently searched job titles are:

What job categories do people searching Sr Python Engineer jobs in Saint Louis, MO look for?

The top searched job categories for Sr Python Engineer jobs in Saint Louis, MO are:

What cities near Saint Louis, MO are hiring for Sr Python Engineer jobs?

Cities near Saint Louis, MO with the most Sr Python Engineer job openings:

Sr Python Engineer jobs near you
Infographic showing various Sr Python Engineer job openings in Saint Louis, MO as of August 2026, with employment types broken down into 73% Full Time, 22% Part Time, and 5% Contract. Highlights an 86% Physical, 5% Hybrid, and 9% Remote job distribution, with an average salary of $136,084 per year, or $65.4 per hour.

Senior Software Engineer 622

Freedom Technology Solutions Group

Saint Louis, MO • Remote

$119K - $157K/yr

Full-time

Re-posted 23 days ago

Job description

Freedom Technology Solutions Group is seeking a Software Developer to support our client's intelligence analysis products and capabilities. This position involves providing software development capabilities to enhance existing and emerging client capabilities, including design and development, modernization of existing applications and services, and operations and sustainment. The role focuses on driving the client's adaptation of higher levels of automation and operational efficiency through agile development methodologies, rapid prototyping, and modern technology stacks. 

The Senior Software Developer provides comprehensive knowledge across multiple backend and cloud technologies, leading major assignments and guiding project outcomes. Functions as a technical expert and may lead teams of developers. 

Responsibilities: 

  • Lead the design, development, and deployment of enterprise-scale backend services.
  • Architect and optimize secure DevSecOps pipelines and automated testing frameworks.
  • Direct the migration, scaling, and modernization of applications in AWS environments.
  • Drive geospatial solution integration across enterprise applications.
  • Define technical standards, coding guidelines, and best practices.
  • Supervise development teams and provide technical mentorship.
  • Evaluate performance results and recommend project-wide improvements.
  • Support proposal writing, technical white papers, and client briefings. 

Key Technologies:

  • Linux
  • Java, JavaScript, Python
  • Containerization (Docker, OpenShift, Kubernetes, ...)
  • AWS Services
  • GitLab
  • Apache Spark, Glue, and other ETL processes/procedures
  • Data Types: Structured and Unstructured, Parquet, JSON, XML, etc. 

Required Qualifications:

  • Active security clearance TS/SCI (eligible for CI Poly).
  • 9-13 years of backend development experience.
  • Expert proficiency in Java, JavaScript, and/or Python.
  • Proven leadership in DevSecOps adoption and Agile/SAFe development frameworks.
  • Advanced AWS expertise, including architecture and deployment of containerized applications.
  • Deep experience with geospatial systems and enterprise integration.
  • Strong ability to plan, manage, and deliver complex technology assignments.
  • Using GitLab for code source repository and using GitLab CI/CD
  • Developing customized code, scripts, modules, macro procedures, or libraries for specialized spatial analysis functions using languages such as Python, Java, JavaScript, PHP, C, C++, C#, Perl, or similar
  • Experience working independently with clients or stakeholders to develop user stories for full-service consumer and business applications 

Desired Qualifications:

  • Experience with government and/or commercial imagery products, including SAR or related RADAR imaging technologies
  • Developing geospatial information systems (GIS) and working with open-source and proprietary geospatial formats
  • Using and developing common geospatial tools, data, and operating platforms such as:
    • Tools: Boundless Spatial suite, Remote View, PostGRES/PostGIS, Oracle Spatial, ArcGIS Desktop, ArcGIS Server, Image Server, File Geodatabases
    • Data Formats: KML, KMZ, NITF, TIFF, JPEG, GeoPDF, and similar geo-related formats and data structures
  • Abstracting new or legacy systems via standards-based APIs, including Open Geospatial Consortium standards
  • Developing terrain analysis visualization and algorithms
  • Developing automated detection algorithms
  • Experience with Argo Workflows 

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