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Senior Python Software Engineer Jobs in Missouri

Jobgether

$5.0K - $6.5K/mo

Our partner is looking for a Senior Python Engineer based in Netherlands. This fully remote ... Experience building reliable, maintainable software with a strong focus on quality and scalability.

Walmart

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are seeking a Senior Software Engineer with information security expertise to help design and ... Expert skills in programming languages such as Java or Python and in interfacing with a backend ...

Walmart

Python Senior Software Engineer

Cassville, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are seeking a Senior Software Engineer with information security expertise to help design and ... Expert skills in programming languages such as Java or Python and in interfacing with a backend ...

Walmart

Python Senior Software Engineer

Anderson, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are seeking a Senior Software Engineer with information security expertise to help design and ... Expert skills in programming languages such as Java or Python and in interfacing with a backend ...

Walmart

Python Senior Software Engineer

Cassville, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

Walmart

Python Senior Software Engineer

Anderson, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

Walmart

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

We are hiring a Senior Software Engineer to help evolve our enterprise SSO platform within IAM. You ... Build secure RESTful APIs and backend services using Java, Go, or Python, and integrate with ...

Walmart

Python Senior Software Engineer

Anderson, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As a Senior Software Engineer in Information Security, you will design, develop, and support ... Python, Java, or similar. * Experience developing and consuming REST APIs and enterprise ...

Walmart

Python Senior Software Engineer

Noel, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As a Senior Software Engineer in Information Security, you will design, develop, and support ... Python, Java, or similar. * Experience developing and consuming REST APIs and enterprise ...

Walmart

Python Senior Software Engineer

Cassville, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As a Senior Software Engineer in Information Security, you will design, develop, and support ... Python, Java, or similar. * Experience developing and consuming REST APIs and enterprise ...

MasterCard

Senior Software Engineer

O Fallon, MO

$114K - $151K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Title and Summary Senior Software Engineer Who is Mastercard? Mastercard is a global technology ... Strict Must-Haves (Non-Negotiable) Python - Proven experience building and operationalizing ...

Mastercard, Inc.

Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Title and Summary Senior Software Engineer Who is Mastercard? Mastercard is a global technology ... Strict Must-Haves (Non-Negotiable) • Python - Proven experience building and operationalizing ...

Biomerieux

Sr. Software Engineer

Hazelwood, MO · On-site

$113K - $149K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

Biomerieux

Sr. Software Engineer

Hazelwood, MO · On-site

$113K - $149K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

Biomerieux

Sr. Software Engineer

Hazelwood, MO · On-site

$113K - $149K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

BioFire Diagnostics

Sr. Software Engineer

Hazelwood, MO

$115K - $152K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

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All JobsPython Software Engineer JobsSenior Python Software Engineer JobsSenior Python Software Engineer Jobs in Missouri

Senior Python Software Engineer information

See Missouri salary details

$51.6K

$133.2K

$182.9K

How much do senior python software engineer jobs pay per year?

As of Aug 19, 2026, the average yearly pay for senior python software engineer in Missouri is $133,174.00, according to ZipRecruiter salary data. Most workers in this role earn between $114,000.00 and $153,400.00 per year, depending on experience, location, and employer.

What does a senior Python software engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

What are the key skills and qualifications needed to thrive as a senior Python software engineer?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What are some common challenges faced by senior Python software engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

Which senior Python software engineer job is in demand?

Senior Python software engineering roles are in high demand across industries such as technology, finance, and healthcare, especially for positions involving data analysis, machine learning, and web development. Skills in frameworks like Django or Flask, along with experience in cloud platforms and version control, enhance job prospects in this field.

What are popular job titles related to Senior Python Software Engineer jobs in Missouri?

For Senior Python Software Engineer jobs in Missouri, the most frequently searched job titles are:

What job categories do people searching Senior Python Software Engineer jobs in Missouri look for?

The top searched job categories for Senior Python Software Engineer jobs in Missouri are:

Senior Python Software Engineer jobs near you

Senior Python Developer

Noor Staffing Group

Saint Louis, MO

$150K - $190K/yr

Full-time

Re-posted 29 days ago

Job description

Position: Senior Python Developer

Location: St. Louis area (onsite)

Salary: $150,000 - $190,000 DOE + full benefits

What you need for this position:

Hold a TS/SCI Clearance

Experience with Python or similar backend programming language (Java, Golang, node.js)

Excellent communication and team skills

5+ years of Software Development experience

Apply