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Senior Python Software Engineer Jobs in Missouri

Sr. Software Engineer

Hazelwood, MO · On-site

$115K - $152K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

Sr. Software Engineer

Hazelwood, MO · On-site

$115K - $152K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and ... Experience developing solutions using Python, including scripting, automation, or data processing ...

Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

Title and Summary Senior Software Engineer Who is Mastercard? Mastercard is a global technology ... All About You Proficiency and hands-on experience building agentic frameworks in Python/TypeScript.

Senior, Software Engineer - Python

Cassville, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As a Senior Software Engineer, you will lead the delivery of scoped features and solutions by collaborating with cross-functional teams to develop, test, and maintain high-quality software systems.

Senior, Software Engineer - Python

Noel, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As a Senior Software Engineer, you will lead the delivery of scoped features and solutions by collaborating with cross-functional teams to develop, test, and maintain high-quality software systems.

Senior, Software Engineer - Python

Anderson, MO · On-site

$90K - $180K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

  • PTO

As a Senior Software Engineer, you will lead the delivery of scoped features and solutions by collaborating with cross-functional teams to develop, test, and maintain high-quality software systems.

Senior Software Engineer

Springfield, MO · On-site +1

$109K - $144K/yr

  • Medical

  • Dental

  • Life

  • Retirement

  • PTO

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Proficiency in one or more back-end languages (e.g., Python, Javascript, TypeScript) and ...

Senior Software Engineer

Columbia, MO · Remote

$116K - $153K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

We're hiring a Senior Software Engineer at our Corporate Headquarters in Columbia, MO , and we're ... AWS, Kubernetes, Python, Kafka, Flink, Snowflake, OpenSearch, PostgreSQL, TypeScript, React, CDKTF ...

Senior Software Engineer

Saint Louis, MO · On-site +1

$114K - $151K/yr

  • Medical

  • Dental

  • Life

  • Retirement

  • PTO

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Proficiency in one or more back-end languages (e.g., Python, Javascript, TypeScript) and ...

Senior Software Engineer

Springfield, MO · On-site +1

$109K - $144K/yr

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Proficiency in one or more back-end languages (e.g., Python, Javascript, TypeScript) and ...

Senior Software Engineer

Jefferson City, MO · On-site +1

$116K - $153K/yr

  • Medical

  • Dental

  • Life

  • Retirement

  • PTO

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Proficiency in one or more back-end languages (e.g., Python, Javascript, TypeScript) and ...

Senior Software Engineer

Saint Louis, MO · On-site +1

$114K - $151K/yr

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Proficiency in one or more back-end languages (e.g., Python, Javascript, TypeScript) and ...

Senior Software Engineer

Kansas City, MO · On-site +1

$119K - $157K/yr

  • Medical

  • Dental

  • Life

  • Retirement

  • PTO

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Proficiency in one or more back-end languages (e.g., Python, Javascript, TypeScript) and ...

Senior Software Engineer

Columbia, MO · On-site

$116K - $153K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

We're hiring a Senior Software Engineer at our Corporate Headquarters in Columbia, MO , and we're ... AWS, Kubernetes, Python, Kafka, Flink, Snowflake, OpenSearch, PostgreSQL, TypeScript, React, CDKTF ...

Senior Software Engineer

Kansas City, MO · On-site +1

$119K - $157K/yr

The Senior Software Engineer designs, builds, and maintains the technical systems and application ... Proficiency in one or more back-end languages (e.g., Python, Javascript, TypeScript) and ...

Senior Software Engineer

Columbia, MO · On-site

$116K - $153K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

We're hiring a Senior Software Engineer at our Corporate Headquarters in Columbia, MO , and we're ... AWS, Kubernetes, Python, Kafka, Flink, Snowflake, OpenSearch, PostgreSQL, TypeScript, React, CDKTF ...

Showing results 21-40

Senior Python Software Engineer information

See Missouri salary details

$51.6K

$133.2K

$182.9K

How much do senior python software engineer jobs pay per year?

As of Aug 20, 2026, the average yearly pay for senior python software engineer in Missouri is $133,174.00, according to ZipRecruiter salary data. Most workers in this role earn between $114,000.00 and $153,400.00 per year, depending on experience, location, and employer.

What does a senior Python software engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

What are the key skills and qualifications needed to thrive as a senior Python software engineer?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What are some common challenges faced by senior Python software engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

Which senior Python software engineer job is in demand?

Senior Python software engineering roles are in high demand across industries such as technology, finance, and healthcare, especially for positions involving data analysis, machine learning, and web development. Skills in frameworks like Django or Flask, along with experience in cloud platforms and version control, enhance job prospects in this field.

What are popular job titles related to Senior Python Software Engineer jobs in Missouri?

For Senior Python Software Engineer jobs in Missouri, the most frequently searched job titles are:

What job categories do people searching Senior Python Software Engineer jobs in Missouri look for?

The top searched job categories for Senior Python Software Engineer jobs in Missouri are:

Sr. Software Engineer

bioMerieux

Hazelwood, MO • On-site

$115K - $152K/yr

Full-time

Medical, Dental, Vision, Life, Retirement

Re-posted 9 days ago


Job description

As a member of the R&D organization responsible for creating software for the development of innovative in vitro diagnostic solutions, the Senior Software Engineer contributes to the design and delivery of scalable, cloud-native software solutions by implementing modern software development practices, including microservices architecture, CI/CD, and infrastructure as code. The Senior Software Engineer works within established architectural frameworks, enhances CI/CD and infrastructure as code solutions, and develops reliable data pipelines and governance practices. The Senior Software Engineer collaborates with cross-functional teams-including data engineering, product management, and architecture-to translate requirements into well-engineered solutions, uphold governance and security standards, and drive continuous improvement through code reviews, prototyping, and technology evaluation.

Primary Duties
  1. Contributes to the design and implementation of multi-tier, distributed, and event-driven systems using cloud-native services and modern design patterns.

  2. Implements infrastructure as code (IaC) solutions using AWS CloudFormation, containerized applications (Docker/Kubernetes), and automated deployment workflows.

  3. Designs and develops microservices-based applications that leverage AWS/ECS/EKS to ensure scalability, security, and resilience.

  4. Designs and develops data pipelines using AWS Lambda, Glue, and other AWS services, following operational standards for availability, performance, and disaster recovery.

  5. Designs and develops RESTful APIs and integrates them with internal and external systems.

  6. Designs and implements data storage solutions, including data lakes and warehouses that enable analytic and operational workloads.

  7. Applies data governance practices-such as data quality, lineage, and security-within the systems and pipelines developed.

  8. Implements integration strategies, APIs, and real-time/stream data solutions to ensure reliable and scalable data flows.

  9. Contributes to technical design discussions and ensures solutions align with system engineering and architectural guidance.

  10. Produces and maintains high-quality system designs, technical documentation, and implementation specifications.

  11. Participates in design reviews, code reviews, and pair programming sessions to share knowledge and promote modern development practices.

  12. Evaluates new technologies, tools, and frameworks, providing recommendations that support technical excellence and business needs.

  13. Works closely with multidisciplinary teams to translate business requirements into technical designs and implementation plans.

  14. Collaborates with cross-functional teams to integrate and optimize processes across teams.

  15. Participates in proof-of-concept efforts by developing prototypes that validate design assumptions and accelerate solution delivery.

  16. Performs other duties as assigned.

Qualifications

Required Education, Training, and Experience

  • Bachelor's degree in Computer Science, Data Engineering, Software Engineering, Biology, Microbiology, Clinical Laboratory Science, Biomedical Engineering, or a related technical or scientific field

  • 7+ years of full stack development experience, including Java and modern web development frameworks such as Angular Suite.

  • Experience with AWS EC2, S3, Lambda Functions, ECS, EKS, RDS.

  • Proven experience with AWS integration/production systems using multiple managed services.

  • Solid grasp of security, compliance, and privacy fundamentals (least privilege, key management, network segmentation).

  • Experience developing and maintaining APIs or serverless patterns.

  • Influence and Code - Terraform (preferred) or AWS CDK/CloudFormation.

  • Implementation strategies for data integration.

  • Strong communication and collaboration skills.

  • Demonstrated architectural design patterns and automated quality gates to improve code health, reduce defects, and accelerate development.

  • Experience with relational databases (PostgreSQL, Oracle, etc.), advanced SQL.

Preferred Education, Training, and Experience

  • Compliance experience (e.g., HIPAA, SOX, ISO 13485, 21 CFR, or other related SDLC concepts).

  • Experience developing solutions using Python, including scripting, automation, or data processing workflows.

  • Automated unit and integration E2E testing framework (PyUnit, Selenium, etc.).

Knowledge, Skills, and Abilities
  • Acting with Honor and Being Open - Upholds and reflects bioMerieux's ethical principles and values.

  • Intellectual Honesty/Openness - Applies problem-solving to complex business challenges.

  • Building Relationships - Demonstrates effective verbal and written communication skills.

  • Creating the New...and Different - Influences change and persuades others to adopt new ideas, behaviors, or processes.

  • Understanding the Business - Demonstrates critical thinking, adaptability, time management, communication, problem-solving, and digital literacy.

  • Intermediate proficiency: applies skills independently in most situations; handles moderately complex tasks with occasional guidance.

  • Skilled in MS Office tools including Outlook, Teams, Word, and Excel.

Working Conditions
  • Ability to remain in a stationary position for prolonged periods.

  • Travel required: 5% (including international travel).

  • Lifting required: No.

  • Other physical requirements: No.

  • Typical office setting with hybrid schedule ( 2 WFH, 3 days in office per week)

The estimated salary range for this role is between $82,000-$115,000. This role is eligible to receive a variable annual bonus based on company, team, and individual performance per bioMerieux's bonus program. This range may differ from ranges offered for similar positions elsewhere in the country given differences in cost of living. Actual compensation within this range is determined based on the successful candidate's experience and will be presented in writing at the time of the offer.
In addition, bioMerieux offers a competitive Total Rewards package that may include:
A choice of medical (including prescription), dental, and vision plans providing nationwide coverage and telemedicine options
Company-Provided Life and Accidental Death Insurance
Short and Long-Term Disability Insurance
Retirement Plan including a generous non-discretionary employer contribution and employer match.
Adoption Assistance
Wellness Programs
Employee Assistance Program
Commuter Benefits
Various voluntary benefit offerings
Discount programs
Parental leaves
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