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Software Engineer Night Shift Remote Jobs in Indiana

micro1 AI

Bioinformatics Software Engineer

South Bend, IN · Remote

$80 - $110/hr

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

Circle

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Florence, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Atlanta, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Boston, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Miami, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Portland, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Columbus, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Nashville, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

Manager, Software Engineering

Austin, IN · On-site +1

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Circle

$195K - $257K/yr

Lead agile software processes for engineering teams and introduce best-in-class industry practices ... You have experience managing remote teams * The ability to thrive on a fast pace environment with ...

Harris

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

In this role, you will directly contribute to that mission by ensuring our software provides a ... This remote role welcomes candidates anywhere in Canada and the US. Travel is required as needed ...

Harris

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

In this role, you will directly contribute to that mission by ensuring our software provides a ... This remote role welcomes candidates anywhere in Canada and the US. Travel is required as needed ...

K1X

Data Engineer

Indianapolis, IN · On-site +1

$109K - $131K/yr

  • Medical

  • Retirement

  • PTO

... software. k1x.io As our platform evolves toward deeper analytics, insights, and AI-driven ... Fully Remote Opportunity * Healthcare Benefits and 401K * Growing Startup Culture

K1X

Data Engineer

Indianapolis, IN · On-site +1

$109K - $131K/yr

  • Medical

  • Retirement

  • PTO

... software. k1x.io As our platform evolves toward deeper analytics, insights, and AI-driven ... Fully Remote Opportunity * Healthcare Benefits and 401K * Growing Startup Culture

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Software Engineer Night Shift Remote information

What are some common challenges faced by remote software engineers working the night shift, and how can they be addressed?

Remote software engineers on the night shift often encounter challenges such as coordinating with daytime teams, managing communication across different time zones, and maintaining a healthy work-life balance due to unconventional hours. To address these issues, it's important to establish clear communication protocols, make use of collaborative tools for asynchronous work, and set personal routines that support both productivity and well-being. Regular check-ins with team members and proactive documentation can also help ensure projects stay on track despite time differences.

What does a software engineer night shift remote do?

A Software Engineer Night Shift Remote works primarily during nighttime hours, often from home or another remote location, to design, develop, test, and maintain software applications. Their responsibilities are similar to those of daytime software engineers but they may also address urgent technical issues, perform system maintenance, or support global teams operating in different time zones. Working remotely at night can help companies provide 24/7 support, meet project deadlines, or collaborate with international staff. This role requires strong technical skills, self-motivation, and effective communication, as most collaboration will occur online.

What are the key skills and qualifications needed to thrive as a software engineer night shift remote?

To thrive as a Software Engineer Night Shift Remote, you need strong programming skills, a solid understanding of software development methodologies, and typically a degree in computer science or related field. Familiarity with version control systems like Git, cloud platforms, and remote collaboration tools such as Slack or Jira is essential. Excellent problem-solving abilities, self-motivation, and effective communication are crucial soft skills, especially when working independently during off-hours. These skills and qualities ensure productivity, code quality, and seamless collaboration with distributed teams despite the challenges of remote night shift work.

What are popular job titles related to Software Engineer Night Shift Remote jobs in Indiana?

For Software Engineer Night Shift Remote jobs in Indiana, the most frequently searched job titles are:

What job categories do people searching Software Engineer Night Shift Remote jobs in Indiana look for?

The top searched job categories for Software Engineer Night Shift Remote jobs in Indiana are:

What cities in Indiana are hiring for Software Engineer Night Shift Remote jobs?

Cities in Indiana with the most Software Engineer Night Shift Remote job openings:

Software Engineer Night Shift Remote jobs near you
Infographic showing various Software Engineer Night Shift Remote job openings in Indiana as of August 2026, with employment types broken down into 90% Full Time, 5% Part Time, and 5% Contract. Highlights an 100% Remote job distribution.

Bioinformatics Software Engineer

micro1 AI

South Bend, IN • Remote

$80 - $110/hr

Part-time

Posted 14 days ago

Job description

Role Title: Computational Biology & Cheminformatics Expert


Role Type: Contractor


Location: Remote


micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer’s computational drug discovery project. In this role, you'll apply your expertise to help train next-generation AI systems. Your work will shape how models learn, reason, and perform through high-quality, real-world input. No prior experience in AI is required — your domain knowledge is what matters.


Scope of Work

  1. Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods.
  2. Curate, annotate, and validate chemical and biological datasets (e.g., ChEMBL, PubChem, DrugBank) to support AI-driven discovery platforms.
  3. Evaluate compound-target interactions, ADMET properties, and lead optimization strategies by integrating chemical, biological, and clinical data sources.
  4. Provide expert insights on structure-activity and structure-property relationships (SAR/SPR), medicinal chemistry approaches, and experimental design considerations.
  5. Build and implement code-based benchmark tasks (e.g., terminal/CLI-based environments) that reflect realistic computational drug discovery scenarios.
  6. Develop reproducible environments (e.g., using Docker) and automated testing pipelines to ensure task correctness and solvability.
  7. Assess and review AI-generated outputs for scientific rigor, accuracy, and practical relevance, delivering detailed written feedback and recommendations.


Preferred Qualifications

  1. Advanced expertise in Computational Biology, Cheminformatics, Medicinal Chemistry, Biochemistry, or related fields; advanced degree (PhD, MSc, PharmD) highly valued but not strictly required.
  2. Strong coding proficiency in Python (beyond analysis scripts), with hands-on experience building tools, pipelines, or testable code; familiarity with Git, GitHub, and Docker.
  3. Extensive experience with cheminformatics toolkits and platforms such as RDKit, KNIME, Schrödinger, OpenEye, or MOE.
  4. Proven track record in small-molecule drug discovery, SAR/QSAR evaluation, ADMET prediction, or virtual screening workflows.
  5. Comfort working with public chemical and bioactivity databases and integrating diverse datasets for scientific analysis.
  6. Demonstrated ability to clearly communicate complex chemical and biological concepts in written feedback and reports.
  7. Experience participating in multidisciplinary and/or remote projects; familiarity with AI-assisted coding tools is a plus.

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