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Single Molecule Biophysics Jobs (NOW HIRING)

Harvard University

Postdoctoral Fellow

Cambridge, MA · On-site

$54K - $73K/yr

Single-molecule fluorescence and FRET; Lasers; Pump-probe experiments -Biophysics of cell signaling and stress response; Biomolecular condensates; G-protein-coupled receptors (GPCRs); Cell and ...

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How much do single molecule biophysics jobs pay per hour?

As of Jun 11, 2026, the average hourly pay for single molecule biophysics in the United States is $21.30, according to ZipRecruiter salary data. Most workers in this role earn between $14.42 and $25.96 per hour, depending on experience, location, and employer.

What is single molecule biophysics?

Single molecule biophysics is a field of science that studies the physical properties and behaviors of individual biological molecules, such as proteins, DNA, and RNA. Unlike traditional biophysics that examines large populations of molecules, single molecule approaches provide detailed insights into molecular mechanisms, dynamics, and interactions. Techniques like optical tweezers, atomic force microscopy, and single-molecule fluorescence are commonly used. This research is important for understanding fundamental biological processes and can lead to advances in medicine and biotechnology.

What are the key skills and qualifications needed to thrive as a Single Molecule Biophysicist, and why are they important?

To thrive as a Single Molecule Biophysicist, you need a strong background in physics, chemistry, and molecular biology, usually supported by an advanced degree (PhD) in biophysics or a related field. Expertise in technical tools such as atomic force microscopy (AFM), optical tweezers, single-molecule fluorescence microscopy, and data analysis software is typically required. Strong analytical thinking, attention to detail, and collaborative communication are essential soft skills in this interdisciplinary field. These skills and qualifications enable accurate experimental design and interpretation, driving innovation and discovery at the molecular level.

What is the difference between Single Molecule Biophysics vs Molecular Biophysics?

AspectSingle Molecule BiophysicsMolecular Biophysics
Required CredentialsPh.D. in Biophysics, Physics, or related fieldPh.D. in Biophysics, Biochemistry, or related field
Work EnvironmentLaboratories focusing on single-molecule techniques, microscopy, and spectroscopyLaboratories studying molecular interactions, structural biology, and biophysical mechanisms
Employer & Industry UsageResearch institutions, universities, biotech companies
Common Search & ComparisonYes

Single Molecule Biophysics focuses on studying individual molecules using specialized techniques like fluorescence microscopy, while Molecular Biophysics examines the physical principles governing molecular interactions and structures. Both fields require advanced degrees and often overlap in research settings, but they differ in their specific methods and focus areas.

What are some common challenges faced by professionals working in single molecule biophysics research?

Professionals in single molecule biophysics often encounter challenges related to the complexity and sensitivity of experimental setups, such as maintaining equipment calibration and minimizing noise that can obscure single-molecule signals. Collaborating closely with interdisciplinary teams—often including physicists, chemists, and biologists—is essential to design experiments, interpret data, and troubleshoot technical issues. Additionally, staying up to date with rapidly evolving technologies and analytical methods is key for success, making continuous learning a significant part of the role.
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Single Molecule Biophysics jobs near you
Infographic showing various Single Molecule Biophysics job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $44,307 per year, or $21.3 per hour.
Postdoctoral Fellow Kleckner Lab

Postdoctoral Fellow Kleckner Lab

Harvard University

Cambridge, MA • On-site

$54K - $73K/yr

Full-time

Posted 6 days ago

Harvard University rating

8.1

Company rating: 8.1 out of 10

Based on 7 frontline employees who took The Breakroom Quiz

131st of 535 rated colleges and universities

Job description

Position
Details
Title
Postdoctoral Fellow Kleckner Lab
School
Faculty of Arts and Sciences
Department/Area
Molecular and Cellular Biology
Position Description
Post-doctoral position available for mechanistic analysis of meiotic crossover interference and high resolution imaging of single molecule dynamics of chromosomes
Basic Qualifications
expertise in high resolution imaging, knowledge of mitotic and meiotic chromosomes, and familiarity with biophysical analyses
Additional Qualifications
Special Instructions
Letters of recommendation are required at the time of application. Candidates should submit with their application contact information for two to three references from experts at the ladder faculty ranks or highly accomplished senior researchers from corporations or research institutes.
Please include the following items as part of your application:
  • Cover letter describing research interests and relevant experience.
  • Curriculum Vitae
  • Summary of research experience and interests.
  • Name and contact information for 2-3 references.

Contact Information
Professor Nancy Kleckner
Northwest Lab Building
52 Oxford Street
Cambridge, MA 02138
Camila Ossa (Administrator)
camila_ossa@harvard.edu
Contact Email
kleckner@fas.harvard.edu
Salary Range
Minimum Number of References Required
2
Maximum Number of References Allowed
3
Keywords

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