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Senior Python Startup Jobs (NOW HIRING)

Senior Software Engineer - Python

$125K - $165K/yr

Senior Python Engineer - Supporting ML Operations Remote (Anywhere) Full-Time, Minimal Travel About ... Startup background - you've thrived in a fast-moving environment and know how to get things done

Senior GenAI Engineer (Python)

Palo Alto, CA · On-site

$142K - $192K/yr

About Us: We are an innovative AI startup focused on transforming professional services through ... As a Senior GenAI Developer, you will lead the design, development, and deployment of scalable ...

Senior GenAI Engineer (Python)

Palo Alto, CA · Hybrid

$142K - $192K/yr

About Us: We are an innovative AI startup focused on transforming professional services through ... As a Senior GenAI Developer, you will lead the design, development, and deployment of scalable ...

Be Seen First

As a Senior GenAI Developer, you will lead the design, development, and deployment of scalable ... Comfortable working in a fast-paced, dynamic startup culture. * Eagerness to learn and contribute ...

AI Engineer

San Jose, CA · On-site

$230K - $280K/yr

Senior AI Engineer / Machine Learning Engineer / Python Software Engineer Location: San Jose, CA Salary: $230K - $280K An AI startup is hiring Mid and Senior Python Software Engineer to join a small ...

About Us: Artera is an AI startup that develops medical artificial intelligence tests to ... Strong proficiency in Python * Demonstrated experience leading the design, development, and ...

About Us: Artera is an AI startup that develops medical artificial intelligence tests to ... Strong proficiency in Python * Demonstrated experience leading the design, development, and ...

ElasticSearch or Lucene - Experience in a fast-paced/customer-centric agile startup environmentSo, if you are a Senior Software Engineer with experience in Object-Oriented Python Development, please ...

ElasticSearch or Lucene - Experience in a fast-paced/customer-centric agile startup environmentSo, if you are a Senior Software Engineer with experience in Object-Oriented Python Development, please ...

They are seeking a Sr. Staff Python Engineer to develop software that automates testing and ... Astra is a rocket launch startup that provides satellite delivery and launch services. Founded in ...

The Sr. Staff Python Engineer will develop software to automate testing and launching rockets ... Astra is a rocket launch startup that provides satellite delivery and launch services. Founded in ...

They are looking for a Sr. Staff Python Engineer to develop software that automates the testing and ... Astra is a rocket launch startup that provides satellite delivery and launch services. Founded in ...

Showing results 21-40

Senior Python Startup information

See salary details

$55K

$142K

$195K

How much do senior python startup jobs pay per year?

As of Aug 15, 2026, the average yearly pay for senior python startup in the United States is $141,976.00, according to ZipRecruiter salary data. Most workers in this role earn between $121,500.00 and $163,500.00 per year, depending on experience, location, and employer.

What is the difference between Senior Python Startup vs Python Developer?

AspectSenior Python StartupPython Developer
CredentialsBachelor's or higher in CS, experience in startupsBachelor's in CS or related field, some experience
Work EnvironmentFast-paced startup, cross-functional teamsEstablished companies or startups, team-based
Industry UsageTech startups, innovative projectsVaried industries, software development
Search IntentSenior roles, startup environment, advanced skillsEntry to mid-level roles, Python programming

Senior Python Startup roles typically require more experience, leadership skills, and familiarity with startup environments. Python Developers may have similar technical skills but often at an earlier career stage and in more established settings. The main difference lies in experience level and work context, with Senior Python Startup positions emphasizing leadership and startup agility.

More about Senior Python Startup jobs

What cities are hiring for Senior Python Startup jobs?

Cities with the most Senior Python Startup job openings:

What are the most commonly searched types of Python Startup jobs?

The most popular types of Python Startup jobs are:

What states have the most Senior Python Startup jobs?

States with the most job openings for Senior Python Startup jobs include:

Infographic showing various Senior Python Startup job openings in the United States as of August 2026, with employment types broken down into 2% Internship, 87% Full Time, 3% Part Time, and 8% Contract. Highlights an 80% Physical, 6% Hybrid, and 14% Remote job distribution, with an average salary of $141,976 per year, or $68.3 per hour.

Sr Python AI Engineer/Architect : Full time

HARAMAIN SYSTEMS INC.

San Francisco, CA • On-site

$150K - $210K/yr

Full-time

Posted 12 days ago


Job description

  • Preference for candidates in/near San Francisco, CA.
  • Visa Sponsorship not available

Role: Sr Python AI Engineer/Architect

Location: Mission District-SF, CA Onsite role

Full-Time Position


Technical Stack

  • TypeScript and Python are primary languages; experience with web stack and Chrome extensions beneficial.
  • Focus on enabling AI tools and infrastructure for rapid development.

Seniority

  • 5+ years of experience in platform engineering.


Work experience

  • Has shipped and maintained production platform infrastructure in a B2B SaaS environment -CI/CD, Kubernetes, containerization, cloud deployments, database migrations; has made painful mistakes and learned from them
  • Startup experience post-Series A; ideally has seen a company grow from Series A-B


You’re a great fit if you have:

  • Built and scaled complex infrastructure systems
  • Worked with Kubernetes, ETL pipelines, AWS/GCP/Cloudflare, CI/CD, and SOC 2 environments
  • Strong judgment across security, reliability, cost, and iteration-speed tradeoffs
  • Been operating at the edge of AI-first development for some time
  • Learned practical lessons from decades of enterprise-grade engineering patterns
  • Strong opinions on how old systems should be improved or replaced
  • High ownership and comfort working across many domains

What you'll do:

  • Build internal platforms and AI loops that increase company iteration speed
  • Strengthen security, compliance, and operational readiness
  • Improve CI/CD, testing, deployments, and developer environments
  • Evaluate and implement new tooling, storage, and compute systems
  • Enable non-technical staff to build and ship improvements safely
  • Enable technical teams to ship scalable, enterprise-ready systems faster
  • Resolve incidents and production fires with both immediate fixes and long-term solutions