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Senior Python Software Engineer Jobs in Indianapolis, IN

The Senior Software Engineer is responsible for defining, implementing, and maintaining custom software products for medium and high throughput automated research systems. Together we'll be giving ...

New

Experience building backend services using languages such as C#, Python, or similar * Understanding of software engineering disciplines and the ability to work across multiple layers of the ...

The Sr. Software Engineer will be responsible for a good portion of development working with ... Some additional languages used includes JavaScript and Python. Must Have: + Experience creating ...

Senior Software Engineer

Carmel, IN · On-site

$122K - $161K/yr

We're seeking a Senior Software Engineer to join us. As a Senior Software Engineer at Zotec, you will be challenged to stretch your expertise in new ways. Develop and maintain enterprise-grade ...

Senior Software Engineer

Carmel, IN · On-site

$122K - $161K/yr

We're seeking a Senior Software Engineer to join us. As a Senior Software Engineer at Zotec, you will be challenged to stretch your expertise in new ways. Develop and maintain enterprise-grade ...

As a Software Engineer at Haystack, you'll play a pivotal role in driving the growth of our product ... g., PHP, .NET, Python, C, TypeScript) * Proven track record of deploying web and mobile ...

As a Software Engineer at Haystack, you'll play a pivotal role in driving the growth of our product ... g., PHP, .NET, Python, C, TypeScript) * Proven track record of deploying web and mobile ...

Senior Software Engineer

Atlanta, IN · Remote

$152K - $205K/yr

The Senior Software Engineer is responsible for extending Circle's in-house blockchain systems infrastructure to support the tokenization of the world; analyzing requirements, procedures, and ...

As a Software Engineer at Haystack, you'll play a pivotal role in driving the growth of our product ... g., PHP, .NET, Python, C, TypeScript) * Proven track record of deploying web and mobile ...

Senior Software Engineer

Indianapolis, IN · On-site +1

$117K - $154K/yr

Senior Software Engineer Department & Team :Genesys Cloud CX and Core Services, Core AI Team Job Reports to :Joe Fruland Job Summary As aSenior Software Engineer, you will be responsible for the ...

Software Engineer Senior - ServiceNow

Indianapolis, IN · On-site +1

$117K - $154K/yr

We are looking for a talented Software Engineer Senior- Service Now to join our team specializing in Systems/Information Technology for our Corporate organization in Indianapolis, IN . In this role ...

Sr Software Engineer

Indianapolis, IN · On-site

$117K - $154K/yr

Summary The Senior Software Engineer creates desired functionality to assigned domain, products or services in application development, that impacts future developments. Supports and may lead ...

Senior Software Engineer

Carmel, IN · On-site

$122K - $161K/yr

The Software Engineer is responsible for developing and supporting the individual components within an application. They will participate in code reviews. Work is expected to be completed correctly ...

Sr Software Engineer

Indianapolis, IN · On-site

$117K - $154K/yr

Summary The Senior Software Engineer creates desired functionality to assigned domain, products or services in application development, that impacts future developments. Supports and may lead ...

Senior Software Engineer

Carmel, IN

$122K - $161K/yr

The Software Engineer is responsible for developing and supporting the individual components within an application. They will participate in code reviews. Work is expected to be completed correctly ...

Embedded Software Engineer

Greenwood, IN · On-site

$124K - $164K/yr

Automating testswithC#,Python,or similar languages. * Testing communication protocols (UART, SPI ... Engineering or Computer Science and preferably 3 or more years' experience in software development ...

Embedded Software Engineer

Indianapolis, IN

$125K - $165K/yr

We're a team of designers, mechanical engineers, electrical engineers, and embedded software ... Experience coding in Javascript, Python, and C++ a plus * Familiar with IDEs such as Visual Studio ...

Embedded Software Engineer

Indianapolis, IN · On-site

$125K - $165K/yr

We're a team of designers, mechanical engineers, electrical engineers, and embedded software ... Experience coding in Javascript, Python, and C++ a plus * Familiar with IDEs such as Visual Studio ...

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Senior Python Software Engineer information

See Indianapolis, IN salary details

$52.6K

$135.7K

$186.4K

How much do senior python software engineer jobs pay per year?

As of Jul 14, 2026, the average yearly pay for senior python software engineer in Indianapolis, IN is $135,710.00, according to ZipRecruiter salary data. Most workers in this role earn between $116,100.00 and $156,300.00 per year, depending on experience, location, and employer.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

What are some common challenges faced by Senior Python Software Engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What are the key skills and qualifications needed to thrive as a Senior Python Software Engineer, and why are they important?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What does a Senior Python Software Engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.
What job categories do people searching Senior Python Software Engineer jobs in Indianapolis, IN look for? The top searched job categories for Senior Python Software Engineer jobs in Indianapolis, IN are:
What cities near Indianapolis, IN are hiring for Senior Python Software Engineer jobs? Cities near Indianapolis, IN with the most Senior Python Software Engineer job openings:
Senior Software Engineer

Senior Software Engineer

Danaher

Indianapolis, IN • On-site

$95K - $105K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 7 days ago

New


Danaher rating

7.7

Company rating: 7.7 out of 10

Based on 29 frontline employees who took The Breakroom Quiz


Job description

Bring more to life.

Are you ready to accelerate your potential and make a real difference within life sciences, diagnostics and biotechnology?

At Beckman Coulter Life Sciences, one of Danaher's 15+ operating companies, our work saves lives-and we're all united by a shared commitment to innovate for tangible impact.

You'll thrive in a culture of belonging where you and your unique viewpoint matter. And by harnessing Danaher's system of continuous improvement, you help turn ideas into impact - innovating at the speed of life.

At Beckman Coulter Life Sciences, we know time is the most critical facet in the laboratory today: time to get life-saving therapies to patients faster; reclaiming time by automating tedious manual workflows; and saving time spent addressing erroneous or complex results.

We are partners in time and accelerate answers to critical questions through the power of automation. We develop innovations for scientists by scientists, with many of our 3,300+ global colleagues coming from the laboratory.

It's all part of our time-tested approach to bringing meaningful innovations at the speed of life since 1935. And we're just beginning. Working together, let's put our time and talents together to advance human health for tomorrow.

Learn about the Danaher Business System which makes everything possible.

The Senior Software Engineer is responsible for defining, implementing, and maintaining custom software products for medium and high throughput automated research systems. Together we'll be giving scientists around the world the tools to craft the next generation of medical treatments, improvements in agricultural crops, and other life science innovations.Work is performed in a team environment consisting of variousengineering disciplines, project managers, and technicians.

This position reports to the Senior Manager, ASG Innovation and is part of the Access Solutions Group located in Indianapolis and will be an on-site role. The ASG delivers over 400 custom projects per year in a fast-paced, collaborative setting.

In this role, you will have the opportunity to:

  • Develop and maintain device integrations for custom liquid handling robotic systems across multiple communication protocols (REST, gRPC, Serial, Web Sockets, SiLA)

  • Own software design and implementation for new product development, collaborating cross functionally with hardware, systems, and application scientists

  • Partner with scientists and lab automation engineers to diagnose and resolve complex integration issues across APIs, services, and third-party devices

  • Debug system behavior across hardware/software boundaries, including timing, communication, and scheduling interactions

The essential requirements of the job include:

  • Bachelor's degree in computer science, software engineering, or related field

  • 5+years of professional software development experience (3+ with a master's degree)

  • Strong verbal and written English communication skills

  • Strong proficiency in C#/.NET (Java experience also considered)

Work Authorization Requirement: Applicants must be legally authorized to work in the United States at the time of application. This position is not eligible for current or future employment visa sponsorship. Candidates who are not U.S. Citizens or U.S. Permanent Residents (Green Card holders), including those working under OPT, CPT, H-1B, TN, or other temporary work authorization statuses, should indicate in their application that they require current or future sponsorship. Providing accurate work authorization information is a requirement of the application process.

It would be a plus if you also possess previous experience in:

  • WPF or desktop application development

  • Containerization and Orchestration technology (e.g. Docker, Podman, Kubernetes)

  • Troubleshooting network-related issues (latency, connectivity, DNS resolution)

  • Hardware integrations or lab automation systems

Beckman Coulter Life Sciences, a Danaher operating company, offers a broad array of comprehensive, competitive benefit programs that add value to our lives. Whether it's a health care program or paid time off, our programs contribute to life beyond the job. Check out our benefits at Danaher Benefits Info.


The salary range for this role $95,000 - $105,000.This is the range that we in good faith believe is the range of possible compensation for this role at the time of this posting. We may ultimately pay more or less than the posted range. This range may be modified in the future.

This job is also eligible for bonus/incentive pay.

We offer comprehensive package of benefits including paid time off, medical/dental/vision insurance and 401(k) to eligible employees.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole discretion unless and until paid and may be modified at the Company's sole discretion, consistent with the law.

Join our winning team today. Together, we'll accelerate the real-life impact of tomorrow's science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life.


For more information, visit www.danaher.com.


Danaher Corporation and all Danaher Companies are committed to equal opportunity regardless of race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law.


The U.S. EEO posters are available here.


For candidates who are based outside of New York City or who are applying for roles outside of New York City, for more information about conditions of any job offer please click here.


We comply with federal and state disability laws and make reasonable accommodations for applicants and employees with disabilities. If reasonable accommodation is needed to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please contact:1-202-419-7762 or applyassistance@danaher.com.


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About Danaher

Sourced by ZipRecruiter

We are a science and technology innovator committed to helping our customers solve complex challenges, and improving quality of life around the world. A global family of more than 20 operating companies, we drive meaningful innovation in some of today's most dynamic, growing industries.

Industry

Medical equipment and supplies manufacturing

Company size

10,000+ Employees

Headquarters location

Washington, DC, US

Year founded

1984