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Mayo Clinic's Genomics and Emerging Systems Unit is seeking a Software Engineer to design, develop, and maintain .NET-based applications and services that support genomics and clinical workflows.  These systems run in on-premises and cloud environments, including Microsoft Azure and Google Cloud Platform (GCP), and integrate with other enterprise systems through secure APIs and web services. The Software Engineer will build and optimize services that handle complex laboratory workflows, clinical datasets, and high-volume genomic data processing. This includes ensuring services meet performance, reliability, data integrity, and quality requirements as data volumes grow.

The role collaborates closely with cross-functional teams to translate business, clinical, and technical requirements into maintainable software solutions that meet federal regulatory guidelines. Software Engineer responsibilities include designing and implementing services aligned to enterprise architecture, including cloud-ready APIs, data integration pipelines, and secure interoperability layers for systems that primarily support genomic data and laboratory workflows.

The engineer participates in Agile and DevOps practices using tools such as GitHub, Azure DevOps, Azure Pipelines, and CI/CD frameworks. Work may include deployment automation and configuration management for both on-premises and cloud-hosted applications. Development efforts leverage modern .NET technologies, cloud-native patterns, API-first design, and secure coding practices. Responsibilities also include maintaining comprehensive technical documentation, contributing to code reviews, and participating in advanced troubleshooting through log analysis, root cause evaluation, and data/system investigation.

This position requires effective communication with peers, leaders, and clinical partners across the organization. The engineer will develop working knowledge of laboratory genomics workflows, organizational processes, and customer needs while performing technical assignments with moderate guidance and increasing autonomy.
This is a full time, limited tenure, remote position funded for 2 years.  Mayo Clinic will not sponsor or transfer visas for this position including F-1 OPT STEM.

Bachelor's degree in Computer Science/Engineering or related field; Or an Associates' degree in Computer Science/Engineering or related field with an additional 2 years of experience as described below. 

• Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.). 
• Demonstrated problem solving and time management skills. 
• Possesses strong technical aptitude for designing and implementing software solutions. 
• Experience with modern application development frameworks 
• Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations. 
• Deep hands-on technical expertise, excellent verbal and written communication skills. 
• Experience with Agile software development techniques. 
   

Preferred qualifications:

• Experience developing applications in hybrid environments, including on-premises systems, Microsoft Azure, and Google Cloud Platform (GCP).
• Proficiency with C# .NET and Angular for developing modern application components, APIs, and web-based user experiences.
• Experience supporting or modernizing legacy Windows desktop applications, including WinForms and/or WPF applications that predate modern cloud-native tooling. Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.). 
• Familiarity with RESTful APIs, microservices, web services, DevOps pipelines, and CI/CD using Azure DevOps, GitHub Actions, Azure Pipelines, or similar tooling.
• Experience with relational or NoSQL databases, analytics platforms, big-data processing, and/or enterprise data pipelines.
• Familiarity with AI coding tools and/or specification-driven development.

• Experience supporting or developing solutions in healthcare, clinical, Bioinformatics or genomics-focused applications is highly desirable.  
  This vacancy is not eligible for sponsorship/we will not sponsor or transfer visas for this position.  Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.

  
   This position is Limited Tenure.  Limited Tenure (LT) means that if you are offered the position and accept it:
       You will be categorized as a regular employee during this tenure, but employment will be terminated at the established end date.
       You commit to stay in this position until the end of the tenure (approximately x months from date of hire) before you become eligible to transfer          to a new position.
       After the completion of the limited tenure assignment, it is your responsibility to secure another role within Mayo through the job vacancy       process or employment will be ended upon the completion of the limited tenure assignment.
   

Bachelor's degree in Computer Science/Engineering or related field; Or an Associates' degree in Computer Science/Engineering or related field with an additional 2 years of experience as described below. 

• Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.). 
• Demonstrated problem solving and time management skills. 
• Possesses strong technical aptitude for designing and implementing software solutions. 
• Experience with modern application development frameworks 
• Knowledge of professional software engineering practices & best practices for the full software development life cycle, including coding standards, code reviews, source control management, build processes, testing, and operations. 
• Deep hands-on technical expertise, excellent verbal and written communication skills. 
• Experience with Agile software development techniques. 
   

Preferred qualifications:

• Experience developing applications in hybrid environments, including on-premises systems, Microsoft Azure, and Google Cloud Platform (GCP).
• Proficiency with C# .NET and Angular for developing modern application components, APIs, and web-based user experiences.
• Experience supporting or modernizing legacy Windows desktop applications, including WinForms and/or WPF applications that predate modern cloud-native tooling. Have working knowledge and experience of Software Engineering with a minimum of internships and a minimum of 1 yr. of experience, or 2yrs of experience coding applications or services in a high-level language (C, C++, Golang, Java, C# etc.). 
• Familiarity with RESTful APIs, microservices, web services, DevOps pipelines, and CI/CD using Azure DevOps, GitHub Actions, Azure Pipelines, or similar tooling.
• Experience with relational or NoSQL databases, analytics platforms, big-data processing, and/or enterprise data pipelines.
• Familiarity with AI coding tools and/or specification-driven development.

• Experience supporting or developing solutions in healthcare, clinical, Bioinformatics or genomics-focused applications is highly desirable.  
  This vacancy is not eligible for sponsorship/we will not sponsor or transfer visas for this position.  Mayo Clinic DOES NOT participate in the F-1 STEM OPT extension program.

  
   This position is Limited Tenure.  Limited Tenure (LT) means that if you are offered the position and accept it:
       You will be categorized as a regular employee during this tenure, but employment will be terminated at the established end date.
       You commit to stay in this position until the end of the tenure (approximately x months from date of hire) before you become eligible to transfer          to a new position.
       After the completion of the limited tenure assignment, it is your responsibility to secure another role within Mayo through the job vacancy       process or employment will be ended upon the completion of the limited tenure assignment.