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Remote Software Engineer 150K Jobs in Missouri (NOW HIRING)

$112K - $148K/yr

Role Specific Information About the Role As Senior Software Engineer, you will collaborate closely with design, product and engineering experts to tackle real-world challenges and deliver innovative ...

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

Join a fast-growing, remote-first technology company building tools that help developers connect applications to the real world through integrations. In this role, you'll combine software engineering ...

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

... software engineering standards. * Excellent technical leadership, communication, problem-solving, and mentoring skills. Benefits * Fully remote work opportunity. * Opportunity to shape the ...

$88K - $106K/yr

Familiarity with Agile methodologies and product-focused software development environments ... Fully remote work environment with flexibility to work from anywhere. * Competitive contract ...

$88K - $106K/yr

Our partner is looking for a Data Engineer based in Netherlands. This is a hands-on data ... for software development, testing, optimization, and operational support. * Remote working ...

Showing results 41-60

Remote Software Engineer 150K information

How does collaboration typically work for remote software engineers, and what tools are commonly used to stay connected with the team?

Remote software engineers often collaborate through digital platforms such as Slack for messaging, Zoom or Microsoft Teams for video meetings, and Jira or Trello for project management. Regular stand-ups and code reviews are scheduled to ensure everyone is aligned and projects stay on track. While the work is independent, strong communication skills are essential, as much of the collaboration happens asynchronously. Many teams also use version control systems like GitHub or GitLab to manage code and facilitate peer reviews.

What does a remote software engineer earning $150K do?

A Remote Software Engineer earning $150K is typically responsible for designing, developing, testing, and maintaining software applications from a remote location. They collaborate with team members using digital communication tools, write clean and efficient code, debug issues, and participate in code reviews. These engineers often work for tech companies or startups, and their high salary reflects their experience, specialized skills, and the complexity of the projects they handle.

What are the key skills and qualifications needed to thrive as a remote software engineer earning $150K?

To thrive as a Remote Software Engineer at this level, you need advanced programming skills, a strong understanding of software development methodologies, and typically a degree in computer science or equivalent experience. Familiarity with version control systems like Git, cloud platforms such as AWS or Azure, and frameworks relevant to your tech stack is essential, alongside certifications like AWS Certified Developer or similar. Strong self-motivation, time management, and excellent written communication are crucial soft skills for collaborating effectively across distributed teams. These abilities ensure consistent delivery of high-quality code, seamless teamwork, and the ability to meet the expectations of a high-paying, remote engineering role.

What are the most commonly searched types of Software Engineer 150K jobs in Missouri?

The most popular types of Software Engineer 150K jobs in Missouri are:

What cities in Missouri are hiring for Remote Software Engineer 150K jobs?

Cities in Missouri with the most Remote Software Engineer 150K job openings:

Infographic showing various Remote Software Engineer 150K job openings in Missouri as of August 2026, with employment types broken down into 59% Full Time, 33% Part Time, and 8% Contract. Highlights an 100% Remote job distribution.

Senior Software Engineer Applied AI

Advanced Monitored Caregiving Inc.

Jefferson City, MO • Remote

$116K - $153K/yr

Full-time

Re-posted 2 days ago


Job description

Senior Software Engineer: Applied AI (Voice Agents & ML Systems)

AMC Health · Remote (US) · Full-time

The pitch

We build and operate production AI voice agents that hold real phone conversations in a regulated healthcare setting, plus the machine learning and LLM pipelines around them. This is one seat that spans four disciplines that rarely come together: real-time systems, LLM engineering, traditional machine learning, and serious cloud infrastructure, all in production, all with real consequences. If you are the kind of engineer who gets restless doing one thing, this role is the opposite problem.

What you'll work across

Real-time voice AI

  • Streaming, low-latency speech-to-speech systems built on modern LLMs
  • Telephony and real-time media (call control, live audio streaming)
  • Audio handling and the quirks of real human conversation (interruptions, timing, noise)
  • Concurrency on a latency-sensitive path, where p99 matters and a stall is something a caller hears

LLM engineering

  • Wrapping nondeterministic models in deterministic control so they behave reliably in production
  • Multi-model pipelines, prompt design, and cost/latency budgeting
  • Evaluation harnesses, including LLM-as-judge and automated agent-tests-agent approaches
  • Agentic tooling that gives AI systems safe, structured access to infrastructure

Traditional (non-LLM) machine learning

  • End-to-end ML pipelines: feature engineering, model training, and scheduled inference
  • Imbalanced, messy real-world data; calibration and explainability for non-technical consumers
  • Turning research notebooks into reproducible, auditable production pipelines

Cloud and infrastructure

  • Infrastructure as code across multiple environments (we run on AWS)
  • Managed compute, data, streaming, and orchestration services
  • Security engineering in a regulated setting: encryption, least-privilege access, strict data-handling discipline
  • Observability and telemetry-driven debugging, tracing a production issue from a metric anomaly to root cause

Plus occasional full-stack work on internal tools, and an engineering workflow that leans heavily on AI coding assistants, with human accountability for every change.

What you'll actually do

  • Ship and debug code on a live, real-time voice pipeline where latency and correctness are user-facing
  • Design control systems around LLMs: guardrails, budgets, watchdogs, safe fallbacks
  • Build and operate LLM evaluation and batch-analysis pipelines
  • Own traditional ML workflows from data to scheduled production inference
  • Trace production issues from a metric anomaly to root cause, including building the evidence when the cause is a vendor

Must-haves

  • 7+ years building and operating production backend systems, with strong general-purpose programming skills (we work primarily in Python)
  • Experience running distributed systems in the cloud; comfortable debugging from telemetry to root cause
  • Hands-on production experience with LLMs or generative AI (any provider or framework), plus the judgment to know when not to use a model
  • Working fluency across the traditional machine learning lifecycle (you productionize; you do not need to publish)
  • Disciplined in a regulated environment: small, reviewable changes and careful handling of sensitive data

Nice-to-haves

  • Real-time media or telephony experience
  • Front-end / full-stack ability
  • ML pipeline experience, vector search, or embeddings
  • Fluency with AI coding assistants (our workflows assume them, with human accountability for every change)

How we work

Smallest correct change wins. Every behavior change is validated against the live system. Evidence over opinion in debugging. Code review is rigorous. Safety and privacy gate everything.

Work authorization (no exceptions)

This role is open only to US citizens and lawful permanent residents (Green Card holders). We cannot consider candidates who require visa sponsorship now or in the future, and we are unable to make exceptions of any kind.

How to apply

Please submit both of the following:

  • Your LinkedIn profile URL
  • A phone number where we can reach you

A resume is welcome but optional; the two items above are required.