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Remote Senior Machine Learning Engineer Jobs (NOW HIRING)

Career Renew

Senior Machine Learning Engineer

Chicago, IL · Remote

$165K - $225K/yr

Career Renew is recruiting for one of its clients a Senior Machine Learning Engineer - this is a fully remote role for US/Canada based candidates. Salary range: 165-225K USD yearly plus benefits plus ...

Career Renew

Senior Machine Learning Engineer

Atlanta, GA · Remote

$165K - $225K/yr

Career Renew is recruiting for one of its clients a Senior Machine Learning Engineer - this is a fully remote role for US/Canada based candidates. Salary range: 165-225K USD yearly plus benefits plus ...

Career Renew

Senior Machine Learning Engineer

New York, NY · Remote

$165K - $225K/yr

Career Renew is recruiting for one of its clients a Senior Machine Learning Engineer - this is a fully remote role for US/Canada based candidates. Salary range: 165-225K USD yearly plus benefits plus ...

OneStudyTeam

Senior Machine Learning Engineer

Boston, MA · Remote

$140K - $190K/yr

By joining our team as a Senior Machine Learning Engineer , you will play a pivotal role in ... LI-Remote We value diversity and believe the unique contributions each of us brings drives our ...

OneStudyTeam

Senior Machine Learning Engineer

$140K - $190K/yr

By joining our team as a Senior Machine Learning Engineer , you will play a pivotal role in ... LI-Remote We value diversity and believe the unique contributions each of us brings drives our ...

Inovalon

Senior Machine Learning Engineer

$125K - $165K/yr

The Senior Machine Learning Engineer will design, train, and deploy machine learning models, collaborating with various business units to improve clinical and operational outcomes at scale.

DailyPay

Senior Machine Learning Engineer

New York, NY · Remote

$190K - $250K/yr

We are seeking a Senior Machine Learning Engineer to join our AI & ML team in New York City. You will play a key role in maturing and scaling our machine learning infrastructure, ensuring the ...

Inovalon

Senior Machine Learning Engineer

$125K - $165K/yr

The Senior Machine Learning Engineer will contribute to both classical machine learning and generative AI applications, working across the full model development lifecycle on a modern, cloud-native ...

Chewy

Senior Machine Learning Engineer

Bellevue, WA · On-site +1

$149K - $245K/yr

At Chewy, our Sponsored Ads Technology team based out of Bellevue, WA is looking for a Senior Machine Learning Engineer to help launch various innovative ads-offerings for Chewy onsite and offsite ...

Chewy

Senior Machine Learning Engineer

Boston, MA · On-site +1

$149K - $245K/yr

At Chewy, our Sponsored Ads Technology team based out of Bellevue, WA is looking for a Senior Machine Learning Engineer to help launch various innovative ads-offerings for Chewy onsite and offsite ...

Signifyd

Senior Machine Learning Engineer I // II

Denver, CO · On-site +1

$107K - $147K/yr

The Senior Machine Learning Engineer will join our ML team. This team is responsible for building ... learning. #LI-Remote Benefits in our US offices: * Discretionary Time Off Policy (Unlimited ...

Orita

Senior Machine Learning Engineer

New York, NY · On-site +1

$180K - $250K/yr

The Role As a Senior Machine Learning Engineer at Orita, you will: * Build and Productionize Models : Design, train, and deploy models that directly power our marketing-focused products, primarily ...

C the Signs

Senior Machine Learning Engineer

Boston, MA · Remote

$125K - $165K/yr

Position Summary The Machine Learning Engineer will be responsible for the end-to-end development ... Flexible working arrangements (remote or hybrid options available). * The opportunity to work on ...

C the Signs

Senior Machine Learning Engineer

Boston, MA · On-site +1

$133K - $175K/yr

Position Summary The Machine Learning Engineer will be responsible for the end-to-end development ... Flexible working arrangements (remote or hybrid options available). * The opportunity to work on ...

Akasa, Inc

Sr. Machine Learning Engineer

$120/hr

About the Role As a Sr. Machine Learning Engineer, you'll report to our Engineering Manager and ... While we support remote work on a variety of teams, we have a strong Bay Area presence across the ...

C the Signs

Senior Machine Learning Engineer

Boston, MA · On-site +1

$133K - $175K/yr

Position Summary The Machine Learning Engineer will be responsible for the end-to-end development ... Flexible working arrangements (remote or hybrid options available). * The opportunity to work on ...

Shaped

Senior Machine Learning Engineer

Brooklyn, NY · On-site +1

$130K - $200K/yr

We're remote but have an office in Brooklyn, New York. We are looking for a machine learning engineer to design, build, experiment and optimize Shaped's AI discovery engine. You will be a founding ...

Amgen, Inc.

Sr Machine Learning Engineer

Thousand Oaks, CA · On-site +1

$109K - $150K/yr

Senior Machine Learning Engineer What you will do Let's do this. Let's change the world. In this ... Flexible work models, including remote and hybrid work arrangements, where possible Apply now and ...

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Remote Senior Machine Learning Engineer information

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$75.5K

$143.3K

$192K

How much do remote senior machine learning engineer jobs pay per year?

As of Jul 24, 2026, the average yearly pay for remote senior machine learning engineer in the United States is $143,292.00, according to ZipRecruiter salary data. Most workers in this role earn between $122,500.00 and $161,500.00 per year, depending on experience, location, and employer.

How do Remote Senior Machine Learning Engineers typically collaborate with cross-functional teams despite working remotely?

Remote Senior Machine Learning Engineers often work closely with data scientists, product managers, and software engineers using digital collaboration tools such as Slack, Jira, and video conferencing platforms. Regular virtual meetings and code reviews are standard practices to ensure alignment on project goals and to facilitate knowledge sharing. Clear communication, proactive documentation, and adaptability to different time zones are key to effective teamwork in a remote environment. This structure allows for flexibility while maintaining strong collaboration and project momentum.

What engineer makes $500,000 a year?

Senior machine learning engineers with extensive experience, advanced skills in deep learning and data modeling, and working at large tech companies or in specialized industries can earn salaries approaching or exceeding $500,000 annually, often including bonuses and stock options. Such compensation typically requires a strong educational background, a track record of impactful projects, and expertise in tools like TensorFlow or PyTorch.

What is the difference between Remote Senior Machine Learning Engineer vs Remote Data Scientist?

AspectRemote Senior Machine Learning EngineerRemote Data Scientist
Required CredentialsBachelor's/Master's in CS, ML, or related; experience with ML frameworksBachelor's/Master's in Statistics, Data Science, or related; strong analytical skills
Work EnvironmentDevelops and deploys ML models, collaborates with engineering teamsAnalyzes data, builds statistical models, provides insights
Employer & Industry UsageTech companies, startups, AI-focused firmsResearch institutions, tech companies, finance, healthcare

Remote Senior Machine Learning Engineers focus on designing, building, and deploying ML models, often working closely with engineering teams. Data Scientists analyze data and develop insights, but may not always deploy models. Both roles require strong technical skills and are highly sought after in tech industries, but their core responsibilities differ.

What are the key skills and qualifications needed to thrive as a Remote Senior Machine Learning Engineer, and why are they important?

To thrive as a Remote Senior Machine Learning Engineer, you need deep expertise in machine learning algorithms, statistical analysis, and strong programming skills (often in Python or similar languages), typically supported by a degree in computer science or a related field. Familiarity with tools such as TensorFlow, PyTorch, cloud platforms (AWS, GCP, or Azure), and experience with data engineering pipelines are commonly required, along with certifications like TensorFlow Developer or AWS Machine Learning Specialty. Excellent problem-solving, communication, and self-management skills help you collaborate remotely, lead projects, and explain complex models to stakeholders. These skills and qualities are vital for building scalable ML solutions, ensuring effective teamwork across distributed environments, and delivering impactful results.

What does a Remote Senior Machine Learning Engineer do?

A Remote Senior Machine Learning Engineer designs, develops, and deploys machine learning models and systems while working from a location outside the traditional office. They collaborate with cross-functional teams, analyze large datasets, build scalable algorithms, and often mentor junior engineers. Their work helps organizations automate processes, gain insights, and improve products or services using data-driven approaches. Senior engineers are also responsible for ensuring model performance, reliability, and integration into production environments. Working remotely, they use various communication and collaboration tools to stay connected with their team.

What engineers make $300,000 a year?

Senior machine learning engineers can earn $300,000 or more annually, especially with extensive experience, advanced skills in deep learning and data modeling, and work at large tech companies or in specialized industries. Compensation often includes base salary, bonuses, and stock options, particularly in high-demand markets.

Will MLE be replaced by AI?

As a Senior Machine Learning Engineer, the role involves designing, developing, and maintaining AI systems, which currently require human expertise. While AI tools can automate certain tasks, the need for skilled professionals to interpret data, ensure ethical use, and improve models remains essential. AI is more likely to augment rather than replace the responsibilities of MLEs in the foreseeable future.

What engineers make $200,000 a year?

Senior machine learning engineers often earn $200,000 or more annually, especially with extensive experience, advanced skills in deep learning and data modeling, and proficiency with tools like TensorFlow or PyTorch. Compensation can vary based on industry, location, and company size, with some roles in tech giants or specialized fields reaching or exceeding this level.
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Remote Senior Machine Learning Engineer jobs near you
Infographic showing various Remote Senior Machine Learning Engineer job openings in the United States as of July 2026, with employment types broken down into 96% Full Time, 1% Part Time, and 3% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $143,292 per year, or $68.9 per hour.

Senior Machine Learning Engineer

Career Renew

Chicago, IL • Remote

$165K - $225K/yr

Full-time

Posted yesterday

Job description

Career Renew is recruiting for one of its clients a Senior Machine Learning Engineer - this is a fully remote role for US/Canada based candidates. Salary range: 165-225K USD yearly plus benefits plus equity.
We are the leading virtual staining company revolutionizing digital pathology adoption worldwide through cutting-edge AI-powered technology. Our solutions deliver diagnostic-quality results in minutes while preserving tissue samples for comprehensive analysis.
Our breakthrough DeepStainâ„¢ and ReStainâ„¢ technologies enable unlimited virtual staining from a single tissue sample, eliminating the bottlenecks and limitations of traditional chemical staining processes. This innovation supports the critical evolution from research applications to clinical deployment, empowering laboratories to advance their digital pathology capabilities while reducing chemical waste, improving operational efficiency, and expanding diagnostic possibilities.

About the Role

We are seeking an experienced Senior ML Engineer to join our team who owns the representation-learning and generative modeling stack that powers Pictor’s virtual staining. The ideal candidate will have deep expertise in Machine Learning and building generalizable, production-ready models, and evaluations that stand up in clinical workflows.
Design and implement novel computer vision and deep learning algorithms for virtual staining and digital pathology applications
Conduct rigorous experiments to evaluate algorithm performance, validate research hypotheses, and drive iterative improvements
Develop and advance ML models leveraging Vision Transformers, Diffusion Models, GANs, and generative architectures for image-to-image translation tasks
Apply classical and learned image enhancement, denoising, and semantic segmentation techniques to histopathology imaging challenges
Explore image representation in latent space for efficient, high-fidelity virtual staining
Stay current with state-of-the-art research, identifying opportunities to apply novel techniques to PictorLabs’ product roadmap

Collaboration
Collaborate with ML Engineering and software teams to translate research prototypes into production-ready systems meeting latency and throughput requirements
Work with large-scale pathology datasets to train, validate, and fine-tune foundation models and custom architectures
Partner with software engineers, data scientists, and pathology domain experts to integrate research into production systems
Contribute to best practices for data engineering, data governance, and data quality across research and production pipelines
Leverage AI coding and ideation tools to accelerate research velocity and prototype new approaches

Required Qualifications

PhD (preferred) or Master’s degree in Computer Science, Electrical Engineering, or a related field
Deep expertise in computer vision and deep learning, with hands-on experience in one or more of: Vision Transformers, Diffusion Models, GANs, semantic segmentation, or classical image enhancement and denoising
Expert proficiency in Python and PyTorch and other scientific computing environments a plus
Strong mathematical foundation in linear algebra, probability, and optimization
Experience with large-scale model training, distributed computing, or cloud ML infrastructure (AWS, GCP, or Azure)
Knowledge of handling large scale image data, data version controls, model registry, has experience dealing with ML lifecycles
Experience with feature search, data balancing, and data curation pipelines.
Knowledge of software engineering best practices including version control (Git) and CI/CD pipelines
Excellent collaboration and communication skills, with the ability to work effectively in a fast-paced, cross-functional international startup environment
Extensive use of AI tools for coding, optimization, and ideation

Preferred Qualifications

Experience with medical imaging, digital pathology, or whole slide image (WSI) processing
Experience with LoRAs, transformer architecture and state of the art image to image translation models (Flux 2, Z-Image) and the Hugging face ecosystem
Background in generative models and fine-tuning of foundation models
Experience with GPU acceleration and optimization, including CUDA kernel engineering, TensorRT/ONNX export, and inference serving frameworks such as Triton
Experience with hosting computer vision model inference on NVIDIA DGX Spark.
Understanding of FDA regulatory requirements for AI/ML in medical devices
Experience with MLOps tools (MLflow, Kubeflow) and model versioning practices
Develop tools and frameworks to streamline ML research workflows, experimentation, and reproducibility

What We Offer

The opportunity to work on technology that directly improves patient outcomes and transforms clinical diagnostics, alongside a talented team of engineers and researchers pushing the boundaries of AI in healthcare. You will have the freedom to pursue high-impact research while seeing your work deployed at scale in real clinical environments.