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Remote Infrastructure Software Engineer Jobs in Cleveland, OH

Aegis Ventures

Principal Software Engineer

Cleveland, OH · On-site +1

$130K - $175K/yr

Architect and lead the development of critical systems, services, and infrastructure - with a focus ... Strong foundation in software engineering best practices , including CI/CD, observability ...

Aegis Ventures

Senior Software Engineer

Cleveland, OH · On-site +1

$118K - $156K/yr

... infrastructure supports their core business, ensuring continued growth and cash flow to fuel their ... About the Job As a Senior Software Engineer , help build and scale a category-defining healthcare ...

System One

Sr Software Engineer

Strongsville, OH · Remote

$125K - $165K/yr

Tittle: Sr. Software Engineer Location: Strongsville, OH or Pittsburgh, PA Work Mode ... Hybrid (3days Office / 2days Remote) Duration: Contract to Hire Years Of Exp Required: 10+ Years ...

System One

Sr Software Engineer

Strongsville, OH · Remote

$125K - $165K/yr

Tittle: Sr. Software Engineer Location: Strongsville, OH or Pittsburgh, PA Work Mode ... Hybrid (3days Office / 2days Remote) Duration: Contract to Hire Years Of Exp Required: 10+ Years ...

System One

Sr Software Engineer

Strongsville, OH · Remote

$125K - $165K/yr

Tittle: Sr. Software Engineer Location: Strongsville, OH or Pittsburgh, PA Work Mode ... Hybrid (3days Office / 2days Remote) Duration: Contract to Hire Years Of Exp Required: 10+ Years ...

System One

Sr Software Engineer

Strongsville, OH · Remote

$125K - $165K/yr

Tittle: Sr. Software Engineer Location: Strongsville, OH or Pittsburgh, PA Work Mode ... Hybrid (3days Office / 2days Remote) Duration: Contract to Hire Years Of Exp Required: 10+ Years ...

System One

Sr Software Engineer

Strongsville, OH · Remote

$125K - $165K/yr

Tittle: Sr. Software Engineer Location: Strongsville, OH or Pittsburgh, PA Work Mode ... Hybrid (3days Office / 2days Remote) Duration: Contract to Hire Years Of Exp Required: 10+ Years ...

System One

Sr Software Engineer

Strongsville, OH · Remote

$125K - $165K/yr

Tittle: Sr. Software Engineer Location: Strongsville, OH or Pittsburgh, PA Work Mode ... Hybrid (3days Office / 2days Remote) Duration: Contract to Hire Years Of Exp Required: 10+ Years ...

System One

Sr Software Engineer

Strongsville, OH · Remote

$125K - $165K/yr

Tittle: Sr. Software Engineer Location: Strongsville, OH or Pittsburgh, PA Work Mode ... Hybrid (3days Office / 2days Remote) Duration: Contract to Hire Years Of Exp Required: 10+ Years ...

CHAMPtitles

Software Engineering Team Lead (UI)

Cleveland, OH · On-site +1

$100K - $134K/yr

As a UI Software Engineering Team Lead, you will work and lead a group of frontend developers using ... office)/Remote if located outside of Cleveland CHAMPtitles is an Equal Opportunity Employer.

micro1 AI

Bioinformatics Software Engineer

Cleveland, OH · Remote

$80 - $110/hr

Remote micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer's computational drug discovery project. In this role, you'll apply your expertise ...

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Remote Infrastructure Software Engineer information

See Cleveland, OH salary details

$112K

$174.8K

$200.3K

How much do remote infrastructure software engineer jobs pay per year?

As of Aug 17, 2026, the average yearly pay for remote infrastructure software engineer in Cleveland, OH is $174,827.00, according to ZipRecruiter salary data. Most workers in this role earn between $167,800.00 and $198,800.00 per year, depending on experience, location, and employer.

What is a remote infrastructure software engineer?

Remote Infrastructure Software Engineers are professionals who design, build, and maintain the core systems and services that support an organization's IT infrastructure, all while working remotely. They focus on ensuring that networks, servers, cloud environments, and related software are secure, scalable, and reliable. Their responsibilities may include automating deployment processes, managing cloud resources, monitoring system performance, and troubleshooting issues. By working remotely, they leverage various collaboration tools to communicate with teams and manage critical infrastructure from anywhere.

How does a remote infrastructure software engineer typically collaborate with cross-functional teams in a distributed work environment?

Remote Infrastructure Software Engineers regularly work with DevOps, security, and development teams to ensure that infrastructure solutions are reliable and scalable. Collaboration often happens through daily stand-ups, code reviews, and shared documentation platforms, making strong communication skills essential. Tools like Slack, Jira, and Zoom are commonly used to bridge the distance and keep projects aligned. Successfully navigating time zone differences and asynchronous communication is a key part of the role, requiring proactive updates and flexibility.

What are the key skills and qualifications needed to thrive as a remote infrastructure software engineer, and why are they important?

To thrive as a Remote Infrastructure Software Engineer, you need a strong background in software engineering, computer networking, and distributed systems, typically supported by a degree in computer science or a related field. Familiarity with cloud platforms (such as AWS, Azure, or GCP), infrastructure-as-code tools (like Terraform or Ansible), and CI/CD systems is essential, along with relevant certifications like AWS Certified Solutions Architect. Excellent problem-solving, communication, and self-management skills are crucial for collaborating effectively across distributed teams and handling complex remote projects. These skills ensure secure, reliable, and scalable systems that support business goals in a remote work environment.

What are the most commonly searched types of Infrastructure Software Engineer jobs in Cleveland, OH?

The most popular types of Infrastructure Software Engineer jobs in Cleveland, OH are:

What are popular job titles related to Remote Infrastructure Software Engineer jobs in Cleveland, OH?

For Remote Infrastructure Software Engineer jobs in Cleveland, OH, the most frequently searched job titles are:

What job categories do people searching Remote Infrastructure Software Engineer jobs in Cleveland, OH look for?

The top searched job categories for Remote Infrastructure Software Engineer jobs in Cleveland, OH are:

What cities near Cleveland, OH are hiring for Remote Infrastructure Software Engineer jobs?

Cities near Cleveland, OH with the most Remote Infrastructure Software Engineer job openings:

Remote Infrastructure Software Engineer jobs near you

Principal Software Engineer

Aegis Ventures

Cleveland, OH • On-site, Remote

$130K - $175K/yr

Full-time

Posted 4 days ago

Job description

About Aegis Ventures
Aegis Ventures partners with entrepreneurs and industry leaders to launch and scale transformative companies in digital health and artificial intelligence. Our platform brings together market-shaping ideas, growth capital, and ambitious individuals to solve major societal problems. With a focus on innovations in healthcare, Aegis has launched four successful portfolio companies in partnership with Northwell Health and recently announced the Digital Consortium to co-develop, invest in, and launch new companies.
About the Company
Avandra Imaging's mission is to unlock clinical data to overcome previously impossible medical challenges, bringing hope and medical breakthroughs that transform patient lives. Avandra is poised to revolutionize healthcare research and innovation by creating the largest indexed data cloud of medical imaging. This platform will unlock unprecedented access to real-world imaging data, essential for biopharma research, medical device innovation, AI model training, and improved patient care.
Leveraging its strategic acquisitions, Avandra aims to aggregate and de-identify vast amounts of imaging data, providing frictionless access to this invaluable resource. With a national footprint of over 5,000 customer integrations and a market share of approximately 70%, this robust infrastructure supports their core business, ensuring continued growth and cash flow to fuel their innovative data cloud platform.
About the Job
As a Principal Software Engineer at Avandra Imaging, you'll serve as a hands-on technical leader, collaborating across Engineering, Product, and other areas of the business to shape and deliver systems that are secure, scalable, and high-impact. You'll be trusted to drive architectural direction, mentor other engineers, and set quality standards across the stack.
This role is ideal for an engineer who thrives in complex technical domains, influences through expertise rather than authority, and elevates the work of others through mentorship, collaboration, and a commitment to engineering excellence.
This role goes beyond individual contributions - you'll model engineering excellence, influence technical strategy, and help foster a team culture built on curiosity, craftsmanship, and care. You'll often lead without authority, earning influence through deep technical insight, sound judgment, and a reputation for raising the bar.
What You'll Do
  • Architect and lead the development of critical systems, services, and infrastructure - with a focus on reliability, security, performance, and maintainability.
  • Partner with product and program leaders to ensure engineering solutions align with user needs, regulatory requirements, and business outcomes.
  • Set and evolve technical standards across the organization. Proactively address tech debt, guide code review quality, and drive initiatives that improve team velocity and code quality.
  • Coach and mentor engineers across teams - helping them grow their craft, navigate ambiguity, and develop in their careers.
  • Investigate and evaluate new technologies to drive innovation, simplify complexity, and support scale.
  • Contribute directly to codebases, especially for architectural foundations, prototypes, and complex or high-risk areas.
  • Serve as a multiplier, identifying gaps, facilitating collaboration, and unblocking teams without taking over.
  • Uphold and strengthen our engineering culture, with a commitment to curiosity, learning, integrity, and positive team dynamics.
  • Help recruit and onboard exceptional talent, contributing to a team that reflects our values and mission.
What You'll Need
  • 12+ years of experience as an engineer across multiple tech stacks, with deep experience building and scaling distributed systems.
  • Proven ability to operate as a technical leader - setting direction, influencing others, and delivering results without formal authority.
  • Strong foundation in software engineering best practices, including CI/CD, observability, automated testing, and infrastructure as code.
  • Experience with cloud-native systems (preferably AWS), including containerization (Docker, Kubernetes)
  • Solid knowledge of relational and non-relational databases,
  • Demonstrated success in a highly regulated environment, preferably healthcare, with an understanding of compliance and data protection (e.g., HIPAA).
  • Effective communicator and cross-functional collaborator, comfortable representing engineering in executive conversations and product strategy.
  • Passion for teaching, mentoring, and cultivating a high-trust, high-autonomy team environment.
What We Offer
  • Meaningful Impact: The work we do directly enables medical breakthroughs - such as earlier cancer detection, better Alzheimer's treatments, AI diagnostics that save lives. This isn't abstract; it's the reason our health system partners invest in us.
  • Career-Defining Opportunity: You'll have a front-row seat to every aspect of building a category-defining company-strategy, operations, fundraising, M&A, scaling.
  • Exceptional Team: Work alongside a founder with a track record of building and exiting healthcare technology companies, backed by investors who are true partners.
  • Competitive Package: Competitive salary, equity, comprehensive benefits, and hybrid work flexibility.
  • Values-Driven Culture: We're building a team grounded in Avandra's 5 Core Values that guide how we show up every day:
    • WIN with Integrity
    • Radical Accountability
    • Engage with Empathy
    • Innovation Through Playful Curiosity
    • Patients First

Aegis Ventures is a proud Equal Opportunity Employer - we recruit, train, compensate and promote our team members based on qualifications. We encourage you to apply regardless of your race, religion, national origin, sex, gender identity, sexual orientation, disability, age, veteran status, or any other applicable legally protected characteristics.

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