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Recombinant Protein Expression Jobs (NOW HIRING)

Marshall University

Postdoctoral Fellow

Huntington, WV · On-site

$47K - $64K/yr

The ideal candidate will possess extensive hands-on experience in microbial construct design, genetic transformation, recombinant protein expression, and targeting those proteins with biochemical ...

Cascade Bio

Research Associate Biocatalysis

Denver, CO · On-site

$60K - $75K/yr

Recombinant Protein Expression & Purification: Express and purify recombinant enzymes (including via cell-free protein synthesis), and assess purity and identity using techniques such as SDS-PAGE.

Aequor

Associate Scientist

Thousand Oaks, CA

... recombinant protein expression, and strong aseptic technique. Candidates should have practical lab experience (preferably with CHO or similar systems such as HEK) and be able to quickly contribute to ...

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How much do recombinant protein expression jobs pay per hour?

As of Sep 15, 2026, the average hourly pay for recombinant protein expression in the United States is $35.05, according to ZipRecruiter salary data. Most workers in this role earn between $25.48 and $41.59 per hour, depending on experience, location, and employer.

What is recombinant protein expression?

A Recombinant Protein Expression job involves producing proteins using genetic engineering techniques in host systems such as bacteria, yeast, insect, or mammalian cells. Professionals in this role design expression vectors, optimize expression conditions, and purify proteins for various applications, including research, therapeutics, and industrial use. The job often requires expertise in molecular biology, biochemistry, and protein purification techniques.

What does recombinant protein expression do?

Professionals in Recombinant Protein Expression typically spend their days designing and constructing DNA constructs, cultivating host cells (like E. coli, yeast, or mammalian cells), and optimizing conditions for protein expression and purification. Routine responsibilities may also include performing quality control assays, troubleshooting experimental issues, maintaining accurate lab records, and preparing reports for stakeholders or regulatory purposes. Collaboration with research scientists, bioinformaticians, or downstream processing teams is common, especially when tailoring protocols for different target proteins. This hands-on and collaborative environment offers a dynamic mix of experimentation and problem-solving each day.

What are the key skills and qualifications needed to thrive in recombinant protein expression?

To thrive in Recombinant Protein Expression, you need a solid background in molecular biology, biochemistry, or a related life sciences field, with experience in gene cloning, vector design, and protein purification techniques. Familiarity with laboratory equipment such as FPLC/HPLC systems, PCR machines, and relevant software (e.g., LIMS, protein modeling tools) is highly beneficial, and certifications in laboratory safety are often valued. Attention to detail, strong problem-solving abilities, and effective teamwork are essential soft skills for success in this field. These abilities ensure the efficient production of high-quality recombinant proteins, support scientific research, and facilitate collaboration within multidisciplinary teams.

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Recombinant Protein Expression jobs near you
Infographic showing various Recombinant Protein Expression job openings in the United States as of September 2026, with employment types broken down into 1% As Needed, 72% Full Time, 24% Part Time, 2% Contract, and 1% Nights. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $72,895 per year, or $35 per hour.

Associate Scientist, Antibody Sciences

Bothell, WA • On-site

Immunome, Inc.
Biotechnology Research and Development • 11 - 50 employees
Learn more about Immunome, Inc.external

$87K - $102K/yr

Full-time

Re-posted 28 days ago

Job description

Company Overview
Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.
Position Overview
Immunome is seeking a highly motivated and detail-oriented Associate Scientist, Antibody Sciences to drive our in-house high-throughput (HTP) recombinant protein production efforts, spanning protein expression, purification, and characterization through basic screening in support of rapid, data-driven protein engineering and discovery workflows.
This position will leverage analytical methods including SEC-UPLC, HIC-UPLC, DLS, reduced mass spectrometry, and biolayer interferometry (BLI) to characterize key properties of generated molecules and inform iterative protein engineering.
A key function of this role will be overseeing the integrity and management of Immunome's recombinant antibody and protein inventory, from intake through material distribution across the organization, enabling efficient iteration and seamless execution across the R&D team.
Responsibilities
Research Design and Execution
  • Recombinant protein production, including high-throughput transient expression and purification.
  • Execute analytical assays including SEC-UPLC, HIC-UPLC, DLS, and reduced mass spectrometry.
  • Perform mammalian tissue culture in support of recombinant protein production.
  • Perform BLI-based assays, including single-point (yes/no) binding and full kinetic binding.
  • Maintain strong attention to detail and record keeping for inventory management of recombinant proteins.
  • Apply understanding of molecular biology and protein structure, including principles relevant to antibodies.

Data Analysis and Interpretation
  • Analyze and summarize experimental data from protein production, characterization, and binding assays.
  • Interpret results and communicate implications to support iterative protein engineering and discovery workflows.

Project Collaboration
  • Collaborate with colleagues across biology, chemistry, pharmacology, and translational medicine to achieve project goals.
  • Organize and share data to enable efficient collaboration with other research teams.

Documentation and Reporting
  • Maintain detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.
  • Prepare and present research findings to internal teams and contribute to project updates and strategic discussions.

Continuous Learning and Development
  • Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics.
  • Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.

Qualifications
  • Bachelor's degree in molecular biology, biochemistry, biophysics, immunology, or related fields.
  • 3 years of lab experience in preclinical drug development in the biotechnology or pharmaceutical industry, or equivalent.
  • Strong understanding of molecular biology and protein sciences.
  • Experience with mammalian tissue culture.
  • Experience with Octet or similar instrument is a plus.
  • Experience with antibody discovery workflows is a plus.
  • Familiarity with Benchling is a plus.

Knowledge and Skills
  • Hands-on experience with recombinant protein expression and purification in high-throughput workflows.
  • Experience applying biophysical and analytical characterization methods (SEC-UPLC, HIC-UPLC, DLS, reduced mass spectrometry).
  • Working knowledge of BLI/Octet assay setup, execution, and data interpretation.
  • Strong laboratory skills in mammalian cell culture and sample handling for protein production.
  • Ability to analyze data, summarize results, and communicate findings to cross-functional teams.
  • Excellent documentation practices, including electronic laboratory notebooks and organized data management.
  • High attention to detail and strong organizational skills, including inventory management and sample tracking.
  • Ability to work effectively in a fast-paced, collaborative research environment and adapt to changing priorities.

Washington State Pay Range
$87,143-$102,002 USD
E/E/O
Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
E-Verify
Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).

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