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Protein Mass Spectrometry Jobs (NOW HIRING)

The Pennsylvania State University

The successful candidate will have a strong foundation in proteomics, mass spectrometry, protein biochemistry, quantitative biology, bioinformatics, or related analytical and computational approaches.

Amgen

Scientist - Protein Biochemist

Thousand Oaks, CA · On-site

Use biochemical and biophysical techniques (e.g., SDS-PAGE, Western blot, spectrophotometry, SEC-MALS, SPR, mass spectrometry) to assess protein quality and stability. Collaborate with team members ...

ImmunEdge Inc.

$106 - $139/hr

Strong analytical skills and experience with SEC-HPLC, CIEX-HPLC, protein mass spectrometry, mass photometry, DLS, and nanoDSF. * Familiar with protein inventory management systems, e.g. Benchling.

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Protein Mass Spectrometry information

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$15

$22

$33

How much do protein mass spectrometry jobs pay per hour?

As of Sep 6, 2026, the average hourly pay for protein mass spectrometry in the United States is $22.62, according to ZipRecruiter salary data. Most workers in this role earn between $18.51 and $24.04 per hour, depending on experience, location, and employer.

What is protein mass spectrometry?

Protein mass spectrometry is an analytical technique used to identify and characterize proteins by measuring the mass-to-charge ratio of their ionized particles. This method allows researchers to determine the composition, structure, modifications, and interactions of proteins in complex biological samples. Protein mass spectrometry is widely used in proteomics, disease biomarker discovery, and pharmaceutical research due to its sensitivity and accuracy.

What are the key skills and qualifications needed to thrive as a protein mass spectrometry specialist?

To thrive as a Protein Mass Spectrometry Specialist, you need a solid background in biochemistry or analytical chemistry, experience with protein analysis techniques, and often an advanced degree (MSc or PhD) in a related field. Proficiency in operating mass spectrometers, using software for data analysis (such as Mascot or MaxQuant), and familiarity with chromatography systems are essential. Attention to detail, problem-solving ability, and strong communication skills help in troubleshooting experiments and collaborating with interdisciplinary teams. These skills ensure accurate protein identification and quantification, supporting critical research and development in biotechnology and pharmaceuticals.

What are some common challenges faced by scientists working in protein mass spectrometry, and how can they be addressed?

One common challenge in protein mass spectrometry is dealing with complex sample mixtures that can lead to overlapping signals and reduced sensitivity. Scientists often address this by optimizing sample preparation protocols and employing advanced separation techniques such as liquid chromatography. Another challenge is data interpretation, as protein identification and quantification require specialized software and bioinformatics skills. Collaboration with bioinformaticians and ongoing training in analytical tools can help overcome these obstacles and improve the accuracy of results.

What is the difference between Protein Mass Spectrometry vs Protein Biochemist?

AspectProtein Mass SpectrometryProtein Biochemist
Required CredentialsBachelor's or Master's in Chemistry, Biochemistry, or related field; specialized training in mass spectrometryBachelor's or Master's in Biochemistry, Molecular Biology, or related field; research experience
Work EnvironmentLaboratories with advanced analytical instruments, research facilitiesResearch labs, academic or industrial settings, often involving experiments and analysis
Industry UsagePharmaceutical, biotech, research institutionsAcademic research, biotech, pharmaceutical companies

Protein Mass Spectrometry specialists focus on analyzing protein samples using mass spectrometry techniques, while Protein Biochemists conduct broader research on protein functions, structures, and interactions. Both roles require strong laboratory skills and scientific knowledge, but Protein Mass Spectrometry roles are more specialized in analytical instrumentation, whereas Protein Biochemists often engage in experimental design and broader biological research.

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What cities are hiring for Protein Mass Spectrometry jobs?

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What job categories do people searching Protein Mass Spectrometry jobs look for?

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Protein Mass Spectrometry jobs near you
Infographic showing various Protein Mass Spectrometry job openings in the United States as of August 2026, with employment types broken down into 84% Full Time, 15% Part Time, and 1% Contract. Highlights an 93% Physical, 3% Hybrid, and 4% Remote job distribution, with an average salary of $47,050 per year, or $22.6 per hour.

Research Technician III - Mass Spectrometry

Howard Hughes Medical Institute (HHMI)

Ashburn, VA • On-site

$54.23 - $67.18/hr

Other

This job post has expired 3 days ago. Applications are no longer accepted.

Job description

Primary Work Address

19700 Helix Drive, Ashburn, VA, 20147

About the role

We are seeking a motivated Research Technician with experience in metabolomics, lipidomics, and/or proteomics to join the mass spectrometry shared resource. The successful candidate will play a key role executing sample preparation and operating LC‑MS/MS systems, serving as a trusted technical resource across a variety of labs and research projects at different stages. We also consider Research Specialist level candidates.

What we provide
  • A competitive compensation package with comprehensive health and welfare benefits
  • A continuous learning environment with opportunities to deepen your technical expertise and expand your scientific knowledge
  • A collaborative and innovative work environment that enables you to provide technical expertise directly supporting scientific breakthroughs
What you’ll do
  • Perform sample preparation, including biomolecule extractions, isotope labeling, protein digestions, LC fractionation, SPE cleanup, and related purifications
  • Operate and maintain state‑of‑the‑art mass spectrometry instruments onsite
  • Assist in daily operation of the mass spectrometry lab, reporting QC assessments of instrument performance, maintaining laboratory workstations, and other related duties
  • Maintain accurate and detailed records of experimental procedures and data analysis results; assist in identifying and troubleshooting unexpected results
  • Proactively contribute to the optimization and validation of metabolomics, lipidomics, and/or proteomics protocols and methodologies
  • Train junior laboratory personnel on proper techniques, equipment use, and safety procedures
What you bring
  • Bachelor’s degree in chemistry, biochemistry, biology, or a closely related field (Master’s degree or higher preferred)
  • At least 4years of hands‑on experience performing metabolomic, lipidomic, or proteomic sample preparations and operating or maintaining LC‑MS/MS systems; for a Master’s candidate, at least 2years is acceptable
  • Proficiency in mass spectrometer operating software (e.g., Thermo Xcalibur)
  • Experience with data analysis software such as Compound Discoverer, LipidSearch, MS‑DIAl, Skyline, Proteome Discoverer, MaxQuant, DIA‑NN, or FragPipe
  • Comfortable operating in a shared resource environment, balancing the needs of multiple research groups while remaining responsive and adaptable
  • Highly organized with strong written and verbal communication skills, sharp attention to detail, and a dependable, team‑oriented work style
Physical Requirements

Remain in a normal seated or standing position for extended periods; reach and grasp by extending hand(s) or arm(s); manipulate objects with fingers; communicate verbally; see and hear within normal parameters; move about the workspace; handle materials weighing up to several pounds (e.g., a laptop or tablet). Work may involve exposure to malodorous vapors, low‑dose radiation, toxic chemicals, acids, and carcinogenic substances. Persons with disabilities may be able to perform the essential duties with reasonable accommodation. Requests for reasonable accommodation will be evaluated individually.

Compensation Range

Research Technician III: $54,230.00 (minimum) – $67,800.00 (midpoint) – $88,110.00 (maximum)
Research Specialist I: $70,290.00 (minimum) – $87,800.00 (midpoint) – $114,180.00 (maximum)
Pay Type: Salary – typically compensated between the minimum and midpoint of the range based on education, experience, knowledge, skills, and abilities.

Equal Opportunity Employer

HHMI is an Equal Opportunity Employer. We use E‑Verify to confirm the identity and employment eligibility of all new hires. Requests for reasonable accommodation will be evaluated on an individual basis. All information provided will be kept confidential and used only to provide needed accommodations. Applicants have rights under federal employment laws.

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