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Protein Mass Spectrometry Jobs (NOW HIRING)

Merck & Co.

The Analytical Enabling Capabilities organization in West Point, PA is seeking a motivated scientist with technical expertise in mass spectrometry-based protein, protein conjugation or ...

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Bench Scientist

Andover, MA

$35.75 - $44.75/hr

* A rare position is available for a bioanalytical scientist to join a state-of-the-art protein mass spectrometry laboratory lab in Pharmaceutical's Pharmacokinetics Dynamics and Metabolism department.

Pioneer Data

Bench Scientist

Andover, MA · On-site

$35.75 - $44.75/hr

A rare position is available for a bioanalytical scientist to join a state-of-the-art protein mass spectrometry laboratory lab in Pharmaceutical's Pharmacokinetics Dynamics and Metabolism department.

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Protein Mass Spectrometry information

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How much do protein mass spectrometry jobs pay per hour?

As of Aug 1, 2026, the average hourly pay for protein mass spectrometry in the United States is $22.62, according to ZipRecruiter salary data. Most workers in this role earn between $18.51 and $24.04 per hour, depending on experience, location, and employer.

What is the difference between Protein Mass Spectrometry vs Protein Biochemist?

AspectProtein Mass SpectrometryProtein Biochemist
Required CredentialsBachelor's or Master's in Chemistry, Biochemistry, or related field; specialized training in mass spectrometryBachelor's or Master's in Biochemistry, Molecular Biology, or related field; research experience
Work EnvironmentLaboratories with advanced analytical instruments, research facilitiesResearch labs, academic or industrial settings, often involving experiments and analysis
Industry UsagePharmaceutical, biotech, research institutionsAcademic research, biotech, pharmaceutical companies

Protein Mass Spectrometry specialists focus on analyzing protein samples using mass spectrometry techniques, while Protein Biochemists conduct broader research on protein functions, structures, and interactions. Both roles require strong laboratory skills and scientific knowledge, but Protein Mass Spectrometry roles are more specialized in analytical instrumentation, whereas Protein Biochemists often engage in experimental design and broader biological research.

What are the key skills and qualifications needed to thrive as a Protein Mass Spectrometry Specialist, and why are they important?

To thrive as a Protein Mass Spectrometry Specialist, you need a solid background in biochemistry or analytical chemistry, experience with protein analysis techniques, and often an advanced degree (MSc or PhD) in a related field. Proficiency in operating mass spectrometers, using software for data analysis (such as Mascot or MaxQuant), and familiarity with chromatography systems are essential. Attention to detail, problem-solving ability, and strong communication skills help in troubleshooting experiments and collaborating with interdisciplinary teams. These skills ensure accurate protein identification and quantification, supporting critical research and development in biotechnology and pharmaceuticals.

What are some common challenges faced by scientists working in protein mass spectrometry, and how can they be addressed?

One common challenge in protein mass spectrometry is dealing with complex sample mixtures that can lead to overlapping signals and reduced sensitivity. Scientists often address this by optimizing sample preparation protocols and employing advanced separation techniques such as liquid chromatography. Another challenge is data interpretation, as protein identification and quantification require specialized software and bioinformatics skills. Collaboration with bioinformaticians and ongoing training in analytical tools can help overcome these obstacles and improve the accuracy of results.

What is protein mass spectrometry?

Protein mass spectrometry is an analytical technique used to identify and characterize proteins by measuring the mass-to-charge ratio of their ionized particles. This method allows researchers to determine the composition, structure, modifications, and interactions of proteins in complex biological samples. Protein mass spectrometry is widely used in proteomics, disease biomarker discovery, and pharmaceutical research due to its sensitivity and accuracy.
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Protein Mass Spectrometry jobs near you
Infographic showing various Protein Mass Spectrometry job openings in the United States as of July 2026, with employment types broken down into 82% Full Time, 17% Part Time, and 1% Contract. Highlights an 93% Physical, 3% Hybrid, and 4% Remote job distribution, with an average salary of $47,050 per year, or $22.6 per hour.

Scientist, Mass Spec & Characterization, Biosimilars ARD

Kashiv BioSciences, LLC

Piscataway, NJ

$35.25 - $44.25/hr

Other

Re-posted 17 days ago

Job description

Description

SUMMARY:


We are seeking a highly motivated, well-organized, and detail-oriented scientist who can work effectively in a fast-paced and multi-disciplinary environment. The position is in the ARD laboratory of Kashiv's Piscataway facility in NJ. The Scientist Mass Spec and Characterization will be responsible for development of LC-MS methods for protein characterization along with other analytical tools involving HPLCs and UV Spectrophotometry. Additional responsibilities include support of method transfer to QC laboratories when required and liaising with CROs and other R&D labs of Kashiv BioSciences. Basic LC-MS and HPLC operation experience is required. Experience with sequence elucidation of protein using LC-MS/MS is desired. The candidate must have experience authoring SOPs and technical reports and should be able to collaborate laboratories for method and data transfer.


Essential Duties and Responsibilities:


Development of LC-MS methods and workflow for sequence elucidation and identification of sites of chemical modification in the sequence.

Development of chromatography methods for quantification of related impurities.

Support sample testing as necessary for various stages of biosimilar development

Provide technical inputs to team members with respect to HPLC/UPLC troubleshooting, method development, method validation, etc.

Ensure adherence to highest quality and efficiency standards in laboratory operations (cGLP, cGMP)

Develop, optimize, and validate new chromatography methods using literature references and scientific principles.

Implement and when necessary, optimize compendial test methods.

Independently write experiment summaries, development reports, technical reports, operation and test method procedure documents, and review documents comprising, but not limited to standard operating procedures, standard test methods, validation protocols and reports, etc.

Foster morale and teamwork. Perform MS analyses of biologics. These studies include but are not limited to, protein molecular weight analysis, peptide mapping, protein sequencing, post-translational modifications qualitative and quantitative analyses, and glycan structural analysis using primarily but not solely high-resolution mass spectrometry.

Prepare chemical solutions and perform detailed and complex analytical procedures (e.g., digestions, purifications, buffer exchanges, etc.) following SOP and established test protocols.

Write and review reports, protocols, and any documentation in relation to the performance of the work.

Work closely with Quality Assurance to meet all necessary regulatory requirements.

Requirements


PREREQUISITES:


Education:


Minimum B.S. degree in Analytical Chemistry, Biophysical/Biochemical Sciences, Pharmaceutical Sciences with 5 years industry experience

Or Master's Degree in Biochemistry, Biotechnology, Biology with 2+ years' experience in protein mass spectrometry

Or Ph.D. in Biochemistry, Biotechnology, Biology with 1+ years of experience in protein mass spectrometry

Experience:

A strong theoretical understanding and experience in protein chemistry and biochemistry.

Experience with operation of LC-MS, HPLC and UV techniques is required.

Experience with HPLC methods like peptide mapping, SEC, CEX is required.

Protein sequencing experience is derived.

Familiar with ICH guidelines and USP/EP pharmacopeia requirements

Excellent communication and technical writing skills

Experience in method development, as well as method qualification/verification/validation in a GLP/GMP environment

Strong experience in analytical method development and validation

Demonstrated skills as a team-player.

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