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Protein Engineering Scientist Jobs (NOW HIRING)

Aragen

Scientist / Sr Scientist

Morgan Hill, CA · On-site

$101K - $138K/yr

Our capabilities span antibody discovery, protein engineering, cell line development, process ... We are seeking a highly motivated Scientist/Senior Scientist, Protein Sciences & Biologics ...

Aragen

Scientist / Sr Scientist

Morgan Hill, CA · On-site

$101K - $138K/yr

Our capabilities span antibody discovery, protein engineering, cell line development, process ... We are seeking a highly motivated Scientist/Senior Scientist, Protein Sciences & Biologics ...

H. T. PROF Group

$82K - $97K/yr

My client offers scientists genuine latitude to pursue creative endeavors and true research. My client seeks a Computational Protein Engineer to build and lead hands-on experimental programs while ...

H. T. PROF Group

Computational Protein Engineer

Rockville, MD · On-site

$113K - $134K/yr

My client offers scientists genuine latitude to pursue creative endeavors and true research. My client seeks a Computational Protein Engineer to build and lead hands-on experimental programs while ...

ImmunEdge Inc.

This role is ideal for a scientist who enjoys hands-on laboratory work and wants to directly ... Partner with the protein-engineering team to recommend molecule redesign and engineering solutions ...

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Protein Engineering Scientist information

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$40.5K

$98.8K

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How much do protein engineering scientist jobs pay per year?

As of Sep 11, 2026, the average yearly pay for protein engineering scientist in the United States is $98,759.00, according to ZipRecruiter salary data. Most workers in this role earn between $78,000.00 and $116,000.00 per year, depending on experience, location, and employer.

What is a protein engineering scientist?

A Protein Engineering Scientist designs and optimizes proteins for specific applications using techniques like directed evolution and computational modeling. They work in biotechnology, pharmaceuticals, or academic research to develop enzymes, antibodies, or therapeutic proteins. Their role includes molecular biology, structural analysis, and laboratory experimentation to improve protein function, stability, or specificity.

What are the typical day-to-day responsibilities of a protein engineering scientist?

As a Protein Engineering Scientist, your daily responsibilities often include designing and executing experiments to modify protein structures, analyzing biochemical data, and troubleshooting experimental results. You’ll regularly use both laboratory techniques and computational tools to optimize protein properties, document your findings, and present data to project teams. Collaboration is a key part of the role, so you’ll frequently interact with colleagues from molecular biology, bioinformatics, and downstream process development groups. This dynamic environment keeps the work intellectually stimulating and offers ongoing opportunities to learn from multidisciplinary teams.

What are the key skills and qualifications needed to thrive as a protein engineering scientist?

To thrive as a Protein Engineering Scientist, you need a strong background in molecular biology, biochemistry, and protein design, typically demonstrated through an advanced degree (MSc or PhD) in a life science field. Experience with techniques such as site-directed mutagenesis, protein expression and purification, and familiarity with analytical tools like HPLC, mass spectrometry, and relevant bioinformatics software is essential. Strong problem-solving abilities, attention to detail, and effective teamwork and communication skills set top candidates apart. Mastery of these areas is crucial for efficiently designing, optimizing, and characterizing proteins that meet organizational and research goals.

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Protein Engineering Scientist jobs near you
Infographic showing various Protein Engineering Scientist job openings in the United States as of September 2026, with employment types broken down into 1% Internship, 90% Full Time, 6% Part Time, 2% Contract, and 1% Nights. Highlights an 83% Physical, 4% Hybrid, and 13% Remote job distribution, with an average salary of $98,759 per year, or $47.5 per hour.

Scientist-Principal Scientist, Protein Design & Structure

Boston, MA • On-site

Superluminal Medicines, Inc.
Biotechnology Research and Development • 1 - 10 employees
Learn more about Superluminal Medicines, Inc.external

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 12 days ago

Job description

About Superluminal Medicines:
Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company's platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation.
Position Summary
We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands-on laboratory work and scientific leadership.
Key Responsibilities
  • Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
  • Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
  • Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.
  • Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
  • Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.

Required Qualifications
  • Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master's or bachelor's degree in a related field with commensurate industry experience.
  • Deep knowledge of GPCR biology and membrane protein structure-function relationships.
  • Proven expertise in molecular biology (cloning, construct design, mutagenesis).
  • Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC).
  • Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).
  • Excellent communication, interpersonal, and leadership skills.

Preferred Qualifications
  • Experience with structural biology methods (data collection and processing for Cryo-EM).
  • Experience in laboratory automation in protein sciences & purification.
  • Background in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

Benefits:
Superluminal offers a comprehensive benefits package that fully covers employees' annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance.
Equal Opportunity Statement:
Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

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