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Protein Engineer Jobs in Massachusetts (NOW HIRING)

Merck & Co.

D (with 7+ years relevant experience) degree in biochemistry, pharmacology, pharmaceutical sciences, protein engineering, molecular biology, bioengineering, or related STEM field; Relevant experience ...

Manifold Bio

Scientist, cDNA Display

Boston, MA

$118K - $138K/yr

Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies. Position Manifold Bio is ...

Manifold Bio

AI/ML Research Engineer

Boston, MA · On-site

$140K - $225K/yr

Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies. Position Manifold Bio is ...

New England Biolabs

Development Scientist I/II

Ipswich, MA · On-site

$87K - $105K/yr

Develop and characterize novel solutions to support protein expression, analysis and modification technologies and workflows, with a particular focus on enabling protein engineering, synthetic ...

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Showing results 21-40

All JobsProtein Engineer JobsProtein Engineer Jobs in Massachusetts

Protein Engineer information

See Massachusetts salary details

$25.7K

$98.7K

$179.2K

How much do protein engineer jobs pay per year?

As of Sep 2, 2026, the average yearly pay for protein engineer in Massachusetts is $98,716.00, according to ZipRecruiter salary data. Most workers in this role earn between $67,584.00 and $124,442.00 per year, depending on experience, location, and employer.

What does a protein engineer do?

A Protein Engineer designs and modifies proteins for specific functions in fields like medicine, biotechnology, and bioengineering. They use computational modeling, molecular biology techniques, and biochemical assays to improve protein stability, activity, or binding properties. Their work is crucial for developing new therapeutics, enzymes, and biomaterials for various industries.

What are the key skills and qualifications needed to thrive as a protein engineer?

To thrive as a Protein Engineer, you need expertise in molecular biology, biochemistry, and protein structure-function analysis, often supported by an advanced degree in a relevant scientific field. Familiarity with tools such as protein modeling software, high-throughput screening systems, and genetic engineering techniques is commonly required. Attention to detail, strong analytical thinking, and effective teamwork are valuable soft skills in this role. These abilities are crucial for designing, optimizing, and testing proteins with desired properties, ensuring impactful contributions to research or product development.

What are the most commonly searched types of Protein Engineer jobs in Massachusetts?

The most popular types of Protein Engineer jobs in Massachusetts are:

What are popular job titles related to Protein Engineer jobs in Massachusetts?

For Protein Engineer jobs in Massachusetts, the most frequently searched job titles are:

What job categories do people searching Protein Engineer jobs in Massachusetts look for?

The top searched job categories for Protein Engineer jobs in Massachusetts are:

Protein Engineer jobs near you
Infographic showing various Protein Engineer job openings in Massachusetts as of August 2026, with employment types broken down into 87% Full Time, 8% Part Time, and 5% Contract. Highlights an 86% Physical, 5% Hybrid, and 9% Remote job distribution, with an average salary of $98,716 per year, or $47.5 per hour.

Research Associate, Protein Chemistry & Bioconjugation (6 MONTH CONTRACT)

Ring Therapeutics

Cambridge, MA

Contractor

Re-posted 17 days ago

Job description

6 MONTH CONTRACT --- ONSITE IN CAMBRIDGE, MACompany Summary

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a new field of targeted medicines by exploiting naturally occurring commensal viruses. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for diseases with high unmet medical need.

Ring Therapeutics was founded in Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines (NASDAQ: GENB) were conceived and created. Since Flagship's founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures resulting in more than 500 issued patents and more than 50 clinical trials for novel therapeutic agents.

Position Summary

We are seeking a motivated and detail-oriented Research Associate to join our Protein Chemistry & Bioconjugation team. This is a hands-on bench role focused on supporting the production, modification, and characterization of antibodies, proteins, and bioconjugates that underpin our targeted therapeutic programs.

The ideal candidate has a solid foundation in standard protein workflows and bioconjugation chemistry and can generate high-quality, decision-driving data to advance platform development. Experience with or exposure to ADC or other biologics research and development is particularly desirable. This is a highly collaborative, hands-on role requiring scientific independence and a strong focus on delivering well-characterized, high-quality protein and conjugate inputs to enable downstream assay development and candidate selection.

Key ResponsibilitiesAntibody & Protein Conjugation
  • Execute common bioconjugation reactions.
  • Prepare and characterize antibody- and protein-conjugated constructs (e.g., fluorophore labeling and payload attachment).
  • Perform post-conjugation purification techniques including desalting columns and TFF.
Protein Processing & Characterization
  • Perform standard protein analytics and concentration measurements
  • Prepare formulation buffers and working reagents
  • Conduct buffer exchange and protein concentration
Lab Operations & Collaboration
  • Maintain accurate experimental records and SOPs in an electronic lab notebook (ELN)
  • Ensure proper inventory management of reagents, consumables, and protein stocks
  • Present data clearly and provide actionable recommendations to project teams
  • Collaborate cross-functionally with targeting, protein engineering, analytical, and translational teams to ensure materials align with program needs
Required Qualifications
  • S. or M.S. in Biochemistry, Bioengineering, Chemistry, or a related field
  • 1-3+ years of hands-on laboratory experience in a biotech, pharma, or academic research setting
  • Demonstrated proficiency in standard protein workflows:
  • Protein concentration measurement (UV-Vis spectroscopy, BCA, Bradford)
  • Protein characterization techniques (SDS-PAGE, DLS)
  • Buffer preparation and formulation
  • Buffer exchange via dialysis
  • Hands-on experience with at least one bioconjugation chemistry approach (e.g., NHS ester, maleimide, click chemistry)
  • Strong attention to detail, excellent organizational skills, and rigorous documentation habits
  • Ability to work independently and collaboratively in a fast-paced research environment
Preferred Qualifications
  • Experience with antibody-drug conjugates (ADCs)
  • Familiarity with TFF systems including Pulse TFF
  • Experience with SEC-HPLC or analytical HPLC for purity/conjugation analysis
  • Experience with protein purification workflows including IMAC, SEC, and ion exchange chromatography
  • Experience with data analysis tools (GraphPad Prism, imageJ)
Key Competencies
  • Hands-on proficiency in bench-scale protein chemistry and bioconjugation
  • Methodical approach to experimental execution and troubleshooting
  • High standards for data quality, reproducibility, and documentation
  • Clear, concise communication of technical results to cross-functional team members
  • Proactive, team-oriented mindset with flexibility to support evolving project priorities

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