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Principal Statistical Programmer Jobs in Durham, NC

The Principal Quality Engineer is working in close collaboration with NPI core development teams ... SPC (statistical process control) Preferred Skills & Experience: * Proficiency with Lean ...

Principal Data Scientist

Raleigh, NC · On-site +1

$147K - $243K/yr

... engineering using statistical techniques; data querying and transformation, including SQL; and working with engineering and ML Ops team members to develop and operationalize data science solutions ...

... and Statistics Education, Science Education, and Engineering and Technology Education. The ... Principal administrative liaison between the graduate student, the graduate program, the Directors ...

Project Engineer - Asphalt

Raleigh, NC · On-site

$61K - $78K/yr

Principals ONLY - NO Recruiters Description Who We Are Vinci Construction USA is a full-service ... The Project Engineer will interface with clients, attend meetings, and provide statistical reports ...

Project Engineer - Asphalt

Raleigh, NC · On-site

$61K - $78K/yr

**Principals ONLY - NO Recruiters** Description Who We Are Vinci Construction USA is a full-service ... The Project Engineer will interface with clients, attend meetings, and provide statistical reports ...

Use data and statistical analysis to drive business decisions and target improved results across ... Experience in multiple programming languages, including R and Python. * Deep understanding of GLMs ...

Showing results 21-40

Principal Statistical Programmer information

See Durham, NC salary details

$50

$76

$105

How much do principal statistical programmer jobs pay per hour?

As of Sep 8, 2026, the average hourly pay for principal statistical programmer in Durham, NC is $76.62, according to ZipRecruiter salary data. Most workers in this role earn between $66.01 and $88.41 per hour, depending on experience, location, and employer.

What is a principal statistical programmer?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the typical daily responsibilities of a principal statistical programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.

What are the key skills and qualifications needed to thrive in the principal statistical programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are popular job titles related to Principal Statistical Programmer jobs in Durham, NC?

For Principal Statistical Programmer jobs in Durham, NC, the most frequently searched job titles are:

What job categories do people searching Principal Statistical Programmer jobs in Durham, NC look for?

The top searched job categories for Principal Statistical Programmer jobs in Durham, NC are:

What cities near Durham, NC are hiring for Principal Statistical Programmer jobs?

Cities near Durham, NC with the most Principal Statistical Programmer job openings:

Infographic showing various Principal Statistical Programmer job openings in Durham, NC as of August 2026, with employment types broken down into 88% Full Time, 10% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $159,363 per year, or $76.6 per hour.

Principal AI Engineer - AI Transformation

Fifth Third

Raleigh, NC • On-site

Full-time

Re-posted 23 days ago


Key responsibilities

  • Design, develop, and implement AI and machine learning systems to address specific business challenges.

  • Create evaluation frameworks to assess model performance, detect hallucinations, and ensure output quality.

  • Collaborate with cross-functional teams to integrate AI solutions into existing systems and communicate technical concepts to stakeholders.


Job description

Make banking a Fifth Third better
We connect great people to great opportunities. Are you ready to take the next step? Discover a career in banking at Fifth Third Bank.

GENERAL FUNCTION:

The Principal AI Engineer architects and implements artificial intelligence and machine learning systems that address diverse business challenges throughout the Bank, with a strong focus on research and experimentation of generative AI models and agentic systems. This role involves conducting rigorous data analysis, performing statistical evaluation, designing experimental frameworks, and developing algorithms that effectively leverage both structured and unstructured data. The AI Engineer creates solutions that range from on-demand analytics to fully integrated software systems, working closely with cross-functional teams to align technical solutions with business requirements. Staying apprised and educating senior leaders on emerging AI trends, risks, and opportunities.

Responsible and accountable for risk by openly exchanging ideas and opinions, elevating concerns, and personally following policies and procedures as defined. Accountable for always doing the right thing for customers and colleagues and ensures that actions and behaviors drive a positive customer experience. While operating within the Bank's risk appetite, achieves results by consistently identifying, assessing, managing, monitoring, and reporting risks of all types.

Essential Duties and Responsibilities

AI Development and Implementation

  • Design, develop, and implement AI and machine learning systems that address specific business challenges and deliver measurable value.
  • Create and maintain model documentation, ensuring transparency in methodologies and approaches.
  • Research, test, and apply state-of-the-art generative AI models and/or solutions for potential use.
  • Develop agentic AI systems capable of autonomous reasoning, planning, and tool utilization for complex task completion.
  • Create comprehensive evaluation frameworks to assess model performance, detect hallucinations, and ensure output quality.
  • Stay current with emerging AI/ML technologies, frameworks, and methodologies.
  • Contribute to establishing best practices for AI development and deployment.
  • Sets enterprise-wide technical standards by defining reference architectures, chairing design reviews, and approving model lifecycle gates (e.g., data sourcing, bias audits, drift monitoring).

Analytics and Insights

  • Extract meaningful patterns and insights from complex, multi-dimensional data sets.
  • Apply advanced analytics including predictive modeling, machine learning, and optimization techniques.
  • Translate business questions into well-defined analytical problems with clear objectives
  • Design and execute experiments with statistically valid methodologies and evaluation criteria.
  • Develop specialized analytics for banking-specific use cases while maintaining compliance with financial regulations.

Collaboration and Communication

  • Leads projects or processes with limited supervision, applying advanced knowledge to solve complex problems.
  • Acts as a resource for colleagues, influencing technical direction and standards across multiple products or platforms.
  • Drives cross-team technical initiatives, ensuring integration, scalability, and compliance across multiple products and platforms.
  • Partner with cross-functional teams to understand business requirements and translate them into technical solutions.
  • Effectively communicate complex technical concepts to non-technical stakeholders.
  • Present findings, recommendations, and insights to business teams in accessible formats.
  • Collaborate with software engineers, cloud engineers, data engineers, and data scientists to integrate AI solutions into existing systems and products.
  • Work with compliance and security teams to ensure AI systems meet banking regulatory requirements.

Minimum Knowledge, Skills and Abilities Required

Education and Experience

  • Bachelor's degree in Computer Science, Statistics, Data Science, Mathematics, or related technical field; Advanced degree preferred but not required.
  • 6+ years of experience developing and deploying machine learning or AI solutions in production environments.

Technical Skills

  • Strong programming skills with proficiency in Python; familiarity with JavaScript and SQL.
  • Expertise in generative AI techniques including prompt engineering, fine-tuning, retrieval-augmented generation (RAG), evaluation frameworks, tool integration, and agentic system design.
  • Experience with cloud computing platforms (AWS preferred, specifically Bedrock, Sagemaker, Lex, etc.).
  • Skilled in data visualization and storytelling, effectively communicating complex analytical insights in clear, actionable formats for technical and non-technical audiences.
  • Experience with machine learning frameworks (PyTorch, scikit-learn, Hugging Face).
  • Practical knowledge of deep learning, neural networks, and traditional ML algorithms.
  • Familiarity with model optimization techniques including quantization and distillation.
  • Knowledge of AI orchestration frameworks (LangChain, LlamaIndex, MCPs, etc.)

Engineering Practices

  • Proficiency with version control systems (Git/GitHub)
  • Understanding of CI/CD pipelines and DevOps practices
  • Experience with containerization and Infrastructure as Code (Docker, Terraform)
  • Knowledge of data structures, algorithms, and software design principles
  • Experience designing observability systems for AI applications

Business and Soft Skills

  • Communicates clearly and builds consensus across teams
  • Mentors colleagues and promotes knowledge sharing
  • Excellent written and verbal communication skills
  • Strong analytical thinking and problem-solving abilities
  • Ability to manage time effectively and prioritize competing demands
  • Self-motivated with demonstrated capacity to work independently
  • Experience working in Agile environments
  • Proficiency with Microsoft Office suite (Word, Excel, PowerPoint)
  • Understanding of ethical considerations in AI deployment

#LI-MB1

Principal AI Engineer - AI Transformation

At Fifth Third, we understand the importance of recognizing our employees for the role they play in improving the lives of our customers, communities and each other. Our Total Rewards include comprehensive benefits and differentiated compensation offerings to give each employee the opportunity to be their best every day.

The base salary for this position is reflective of the range of salary levels for all roles within this pay grade across the U.S. Individual salaries within this range will vary based on factors such as role, relevant skillset, relevant experience, education and geographic location. In addition to the base salary, this role is eligible to participate in an incentive compensation plan, with any such payment based upon company, line of business and/or individual performance.

Our extensive benefits programs are designed to support the individual needs of our employees and their families, encompassing physical, financial, emotional and social well-being.You can learn more about those programs on our 53.com Careers page at: https://www.53.com/content/fifth-third/en/careers/benefits.html or by consulting with your talent acquisition partner.

LOCATION -- Frisco, Texas 75034

Attention search firms and staffing agencies: do not submit unsolicited resumes for this posting. Fifth Third does not accept resumes from any agency that does not have an active agreement with Fifth Third. Any unsolicited resumes - no matter how they are submitted - will be considered the property of Fifth Third and Fifth Third will not be responsible for any associated fee.

Fifth Third Bank, National Association is proud to have an engaged and inclusive culture and to promote and ensure equal employment opportunity in all employment decisions regardless of race, color, gender, national origin, religion, age, disability, sexual orientation, gender identity, military status, veteran status or any other legally protected status.