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RDI

Principal CRA - Monitoring Standards & Training

$100K - $115K/yr

About RDI RDI is an IVD-focused contract research organization. Since 2008 we've run 300+ diagnostic trials for the largest test makers in the world. Our clinical operations team is sharp, motivated ...

City of Haines City

CRA Manager

Haines City, FL · On-site

$79K - $114K/yr

Responsible for reporting as required under Florida State Statute 163, Part III. * Serves as principal staff person for the Community Redevelopment Agency (CRA). Responsible for the maintenance and ...

City of Haines City

CRA Manager

Haines City, FL · On-site

$79K - $114K/yr

Responsible for reporting as required under Florida State Statute 163, Part III. * Serves as principal staff person for the Community Redevelopment Agency (CRA). Responsible for the maintenance and ...

City of Haines City

CRA Manager

Haines City, FL

Responsible for reporting as required under Florida State Statute 163, Part III. * Serves as principal staff person for the Community Redevelopment Agency (CRA). Responsible for the maintenance and ...

Novotech

Clinical Research Associate

$70K - $110K/yr

The CRA is the primary contact between the Investigational Sites, Novotech, and Sponsor. Key ... CRAs primary responsibility is to build relationships with Principal Investigators, study co ...

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How much do principal cra jobs pay per year?

As of Jun 8, 2026, the average yearly pay for principal cra in the United States is $109,393.00, according to ZipRecruiter salary data. Most workers in this role earn between $85,000.00 and $125,000.00 per year, depending on experience, location, and employer.

What is a Principal CRA job?

A Principal Clinical Research Associate (CRA) is a senior-level professional responsible for overseeing clinical trials to ensure compliance with regulatory guidelines, protocols, and ethical standards. They provide leadership in site management, monitor data quality, and mentor junior CRAs. Principal CRAs collaborate with sponsors, investigators, and regulatory bodies to ensure successful trial execution. Their role often involves problem-solving, risk assessment, and implementing best practices to maintain study integrity.

What are some typical responsibilities and challenges faced by a Principal CRA in a clinical trial setting?

As a Principal CRA, you are responsible for overseeing site management activities, ensuring regulatory compliance, mentoring junior CRAs, and serving as a primary point of contact for complex study sites. One common challenge is managing multiple sites or projects simultaneously while maintaining high standards for quality and adherence to timelines. You will also collaborate closely with cross-functional teams such as data management, project management, and regulatory affairs. This role often requires proactive problem-solving, leadership, and adaptability in a fast-paced and highly regulated environment. Advancing to this level can open doors to positions such as Clinical Trial Manager or Clinical Project Lead.

What are the key skills and qualifications needed to thrive in the Principal Cra position, and why are they important?

To thrive as a Principal CRA (Clinical Research Associate), you need extensive experience in clinical trial monitoring, regulatory compliance, and a solid understanding of Good Clinical Practice (GCP) guidelines, usually supported by a science degree. Expertise with electronic data capture (EDC) systems, clinical trial management systems (CTMS), and relevant certifications such as ACRP or SOCRA is highly valued. Strong leadership, problem-solving, and communication skills are essential for managing teams and coordinating across various stakeholders. These competencies are vital for ensuring the quality, integrity, and successful execution of complex clinical research projects.

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Principal Cra jobs near you
Principal Clinical Research Associate (Remote)

Principal Clinical Research Associate (Remote)

Astrix Inc

Cleveland, OH • On-site, Remote

$65 - $80/hr

Full-time

Posted 27 days ago

Job description

Pay Rate Low: 75 | Pay Rate High: 85
We are seeking a high-level, technically proficient Principal CRA to oversee complex monitoring activities for specialized Medical Device trials.
Job Title: Senior / Principal Clinical Research Associate (Medical Device)
Term: 12-Month Renewable Contract (Plus Benefits)
Compensation: $65-80/hr
Travel: Approximately 60% The Role
We are seeking a high-level, technically proficient Senior or Principal CRA to oversee complex monitoring activities for specialized Medical Device trials. Unlike high-volume CRO environments, this role requires a "hands-on" expert who possesses the deep clinical intuition and technical skills that only come with years of dedicated field experience.
You will manage site performance across the country, focusing on high-enrollment sites and long-term follow-up monitoring.
What Sets You Apart
  • True Seniority: You have 5+ years of experience and have mastered the nuances of site management. You are looking for a role where your actual skill set-not just your title-is utilized.
  • Medical Device Expertise: You have a proven track record specifically in the Medical Device sector. Experience in Cardiology is a significant advantage.
  • Site Management Prowess: You prioritize site health and data integrity over "checking boxes." You excel at managing site volume, patient enrollment, and rigorous long-term monitoring.
  • Stability: Your career history reflects commitment and steady growth rather than rapid-fire jumping or title inflation.
Core Responsibilities
  • Conduct comprehensive monitoring visits (PSV, SIV, RM, COV) across country
  • Manage a high volume of site activities, ensuring adherence to protocols, IDE regulations, and ISO 14155 standards.
  • Drive enrollment and oversee long-term patient follow-up for complex device studies.
  • Act as a primary liaison for clinical sites, fostering strong investigator relationships.
Qualifications
  • Minimum 5+ years of CRA experience (must be at a Senior or Principal level).
  • Direct Medical Device monitoring experience is required.
  • Cardiology therapeutic experience is highly preferred.
  • Experience outside of "Big CRO" environments is preferred; we value versatile talent capable of working independently.
  • Ability to travel 60% of the time (approx. 2 weeks/month).
  • Must be based in the U.S.; Central Time Zone is a plus to bridge Eastern and Western engagements.
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