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Principal Bioinformatics Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

Legend Biotech is seeking a Principal Bioinformatician as part of the Early Drug Development team ... sciences. Strong expertise in bioinformatics, statistics with some biological training background ...

AskBio

Principal Scientist, Delivery

Durham, NC · On-site

Working closely with crossfunctional partners-including bioinformatics, vector biology, translational, and therapeutic teams-the Principal Scientist will oversee multiple highimpact projects, provide ...

Formation Bio

Principal Data Scientist

New York, NY

$204K - $267K/yr

About the Position As a Principal Data Scientist at Formation Bio, you will be at the forefront of ... Extensive experience in multi-modal bioinformatics analysis Preferred Qualifications * Proven ...

NCBiotech

Principal Scientist, Delivery

Durham, NC · On-site

$150 - $210/hr

Working closely with cross‑functional partners--including bioinformatics, vector biology, translational, and therapeutic teams--the Principal Scientist will oversee multiple high‑impact projects ...

New

University of Utah

Bioinformatics Management

Campus, IL · Hybrid

$110K - $122K/yr

A senior scientific, clinical informatics, and team-leadership role. It serves as the primary ... Partner with principal investigators during grant development to define informatics scopes of work ...

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How much do principal bioinformatics scientist jobs pay per year?

As of Aug 7, 2026, the average yearly pay for principal bioinformatics scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What is a principal bioinformatics scientist?

A Principal Bioinformatics Scientist is a senior-level expert who leads the development and application of computational techniques to analyze biological data, such as genomics or proteomics. They design algorithms, manage large datasets, and collaborate with biologists, clinicians, and data scientists to derive meaningful insights. Their responsibilities often include leading research projects, mentoring junior scientists, and contributing to scientific publications or regulatory submissions. This role is critical in fields like pharmaceuticals, biotechnology, and biomedical research, where data-driven discoveries inform drug development and personalized medicine.

What are the key skills and qualifications needed to thrive as a principal bioinformatics scientist?

To excel as a Principal Bioinformatics Scientist, one typically needs an advanced degree in bioinformatics or a related field, extensive experience with genomic data analysis, and strong expertise in programming languages such as Python, R, or Perl. Familiarity with bioinformatics software, databases like NCBI or Ensembl, and cloud computing platforms is often required, and relevant certifications in genomics or data science can be advantageous. Exceptional leadership, communication, and project management skills help facilitate collaboration and drive complex research initiatives. These competencies are critical for leading multidisciplinary teams, interpreting sophisticated datasets, and advancing scientific discovery in life sciences organizations.

What does a principal bioinformatics scientist do?

A Principal Bioinformatics Scientist typically oversees the design, execution, and interpretation of large-scale bioinformatics projects, analyzing complex biological datasets to derive actionable insights. On a daily basis, they may supervise junior scientists, manage collaborations with experimental biologists or clinicians, and ensure the accuracy and integrity of data analyses. They are also involved in reviewing project progress, communicating findings to stakeholders, and staying updated with the latest advancements in bioinformatics tools and methodologies. This blend of hands-on technical work, mentorship, and strategic planning makes each workday dynamic and intellectually stimulating.

Is principal bioinformatics scientist well paying?

Principal bioinformatics scientists typically earn high salaries due to their advanced expertise, leadership responsibilities, and experience in computational biology and data analysis. Compensation often includes base salary, bonuses, and benefits, reflecting the demand for specialized skills in biotech and pharmaceutical industries.
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Principal Bioinformatics Scientist jobs near you
Infographic showing various Principal Bioinformatics Scientist job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, 9% Part Time, 1% Temporary, and 1% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.

Principal Scientist - NGS/Genomics and Bioinformatics

Thermo Fisher Scientific

Richmond, VA • On-site

Full-time

Re-posted 19 days ago

Thermo Fisher Scientific rating

7.7

Company rating: 7.7 out of 10

Based on 422 frontline employees who took The Breakroom Quiz

196th of 536 rated manufacturers

Job description

Work Schedule
Standard (Mon-Fri)
Environmental Conditions
Cleanroom: no hair products, jewelry, makeup, nail polish, perfume, exposed piercings, facial hair etc... allowed, Laboratory Setting, Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)
Job Description
This is a fully onsite role based in our bioanalytical laboratory in Richmond, VA. We welcome applicants from all locations within the US. Please note that relocation assistance is not provided for this position, and any relocation costs will be the responsibility of the candidate.
Must be legally authorized to work in the United States without sponsorship.
Must be able to pass a comprehensive background check, which includes a drug screening.
At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on - now and in the future.
Our PPD® Laboratory Services team has a direct impact on improving patient health through the expertise of scientists, industry thought-leaders and therapeutic experts. As the world leader in serving science, our laboratory professionals bring their commitment to accuracy and quality to deliver groundbreaking innovations.
Discover Impactful Work:
Discover Impactful Work: We are seeking a Principal Scientist to lead the strategy, design, and implementation of our NGS sequencing platforms. This role defines the next phase of our laboratory's molecular innovation-combining sequencing, proteomics, and spatial transcriptomics to deliver integrated multi-omics solutions.
A Day in the Life:
  • Oversee setup, qualification, and validation of the Ultima and/or Illumina NGS system
  • Lead evaluation and implementation of genomics and proteomics technologies (NextGen Sequencing (WGS, RNASeq, targeted sequencing), spatial sequencing (10x Genomics Chromium, Visium, Xenium), O-Link HT, NuLISA)
  • Define and execute the sequencing strategy for the lab, aligning with organizational and client objectives
  • Mentor scientists and analysts in NGS workflows, QC, and data interpretation including bioinformatics support
  • Partner with automation, bioinformatics, and proteomics teams for multi-omics integration
  • Represent the lab in vendor partnerships, conferences, and technical collaborations

Keys to Success:
  • Bachelor's degree or equivalent and relevant formal academic / vocational qualification
  • Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 12+ years') or equivalent combination of education, training, and experience.
  • OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 10+ year)
  • OR PhD and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable 8+ year)

In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
Knowledge, Skills and Abilities:
  • Demonstrated leadership in launching or managing NGS and spatial sequencing platforms and analysis
  • Ultima and/or Illumina NGS - MUST HAVE
  • Proven track record of cross-functional scientific leadership and technical innovation
  • Expert knowledge of sequencing chemistry, data QC, and assay validation, data analysis/bioinformatics
  • Experience integrating sequencing with proteomics or other omics technologies
  • Strong communication and external collaboration skills
  • Strategic mindset with ability to identify and implement new technologies
  • Demonstrated success mentoring staff and building scientific teams

Working Conditions and Environment:
Work is performed in a laboratory and/or a clinical environment with exposure to electrical office equipment.
  • Occasional drives to site locations, occasional domestic travel
  • Exposure to biological fluids with potential exposure to infectious organisms
  • Rare exposure to skin and lung irritants, radiation, toxic materials and hazardous waste
  • Personal protective equipment required such as protective eyewear, garments and gloves
  • Exposure to fluctuating and/or extreme temperatures on rare occasions

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