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Principal Bioinformatics Scientist Jobs (NOW HIRING)

AskBio

Principal Scientist, Delivery

Durham, NC · On-site

Working closely with cross-functional partners-including bioinformatics, vector biology, translational, and therapeutic teams-the Principal Scientist will oversee multiple high-impact projects ...

AskBio

Principal Scientist, Delivery

Durham, NC · On-site

Working closely with crossfunctional partners-including bioinformatics, vector biology, translational, and therapeutic teams-the Principal Scientist will oversee multiple highimpact projects, provide ...

Formation Bio

Principal Data Scientist

New York, NY

$204K - $267K/yr

About the Position As a Principal Data Scientist at Formation Bio, you will be at the forefront of ... Extensive experience in multi-modal bioinformatics analysis Preferred Qualifications * Proven ...

Battelle

Bioinformaticist

Columbus, OH · On-site

Using methods like principal component analysis, spectral decomposition, t-SNE, UMAP for data ... Degree must be in bioinformatics, biology, genetics, computer science, mathematics, or a related ...

University of Rochester

$77K - $115K/yr

Contributes to scientific analysis of data generated by multiple research projects by organizing ... Knowledge of basic statistics, linear model building, principal component analysis, and factor ...

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All JobsPrincipal Bioinformatics Scientist Jobs

Principal Bioinformatics Scientist information

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$68.5K

$144K

$190.5K

How much do principal bioinformatics scientist jobs pay per year?

As of Jun 27, 2026, the average yearly pay for principal bioinformatics scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What is a Principal Bioinformatics Scientist job?

A Principal Bioinformatics Scientist is a senior-level expert who leads the development and application of computational techniques to analyze biological data, such as genomics or proteomics. They design algorithms, manage large datasets, and collaborate with biologists, clinicians, and data scientists to derive meaningful insights. Their responsibilities often include leading research projects, mentoring junior scientists, and contributing to scientific publications or regulatory submissions. This role is critical in fields like pharmaceuticals, biotechnology, and biomedical research, where data-driven discoveries inform drug development and personalized medicine.

What are the key skills and qualifications needed to thrive in the Principal Bioinformatics Scientist position, and why are they important?

To excel as a Principal Bioinformatics Scientist, one typically needs an advanced degree in bioinformatics or a related field, extensive experience with genomic data analysis, and strong expertise in programming languages such as Python, R, or Perl. Familiarity with bioinformatics software, databases like NCBI or Ensembl, and cloud computing platforms is often required, and relevant certifications in genomics or data science can be advantageous. Exceptional leadership, communication, and project management skills help facilitate collaboration and drive complex research initiatives. These competencies are critical for leading multidisciplinary teams, interpreting sophisticated datasets, and advancing scientific discovery in life sciences organizations.

What are the typical daily responsibilities of a Principal Bioinformatics Scientist?

A Principal Bioinformatics Scientist typically oversees the design, execution, and interpretation of large-scale bioinformatics projects, analyzing complex biological datasets to derive actionable insights. On a daily basis, they may supervise junior scientists, manage collaborations with experimental biologists or clinicians, and ensure the accuracy and integrity of data analyses. They are also involved in reviewing project progress, communicating findings to stakeholders, and staying updated with the latest advancements in bioinformatics tools and methodologies. This blend of hands-on technical work, mentorship, and strategic planning makes each workday dynamic and intellectually stimulating.

More about Principal Bioinformatics Scientist jobs
What cities are hiring for Principal Bioinformatics Scientist jobs? Cities with the most Principal Bioinformatics Scientist job openings:
What states have the most Principal Bioinformatics Scientist jobs? States with the most job openings for Principal Bioinformatics Scientist jobs include:
What job categories do people searching Principal Bioinformatics Scientist jobs look for? The top searched job categories for Principal Bioinformatics Scientist jobs are:
Principal Bioinformatics Scientist jobs near you
Infographic showing various Principal Bioinformatics Scientist job openings in the United States as of June 2026, with employment types broken down into 91% Full Time, 7% Part Time, 1% Temporary, and 1% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.
Principal Scientist - Computational Histopathology Lead

Principal Scientist - Computational Histopathology Lead

Yoh, A Day & Zimmermann Company

Collegeville, PA

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 10 days ago

Job description

Principal Scientist – Computational Histopathology Lead needed for a contract opportunity with Yoh Scientific’s client located in Collegeville, PA.
This position requires a Master's degree in Computational Biology, Bioinformatics, Biomedical Engineering, Computer Science, Data Science, Pathology, Biostatistics, or related scientific discipline. Schedule is full-time M-F (7am-8am start time, 8 hour shift) and may require flexibility to work some evenings and overtime due to projects.
 
Primary Duties:
The Principal Scientist – Computational Histopathology Lead will serve as the scientific and technical lead for computational pathology initiatives supporting biomarker discovery, translational research, and digital pathology innovation. This role is responsible for leading the design, development, validation, and deployment of advanced image analysis and machine learning solutions applied to histological and whole-slide imaging data. The individual will provide strategic direction for computational pathology workflows, oversee scientific execution across multidisciplinary teams, and ensure the successful delivery of project milestones in support of pharmaceutical R&D programs.
 
Key Responsibilities:
Scientific Leadership
  • Provide scientific leadership and technical oversight for computational pathology programs supporting biomarker discovery and translational research initiatives.
  • Define and execute computational pathology strategies aligned with project objectives and scientific priorities.
  • Lead multidisciplinary teams consisting of computational scientists, pathologists, data engineers, image analysts, and laboratory personnel.
  • Serve as the primary scientific liaison between research, pathology, bioinformatics, translational medicine, and external stakeholders.
  • Present scientific findings, project updates, and strategic recommendations to senior leadership and project governance committees.
Computational Pathology & Image Analysis
  • Lead the development, validation, optimization, and deployment of computational pathology pipelines for histological image analysis.
  • Design and implement machine learning and artificial intelligence approaches for tissue classification, segmentation, biomarker quantification, and predictive modeling.
  • Oversee development of image analysis algorithms using commercial and open-source platforms, including Halo AI, Visiopharm, QuPath, and CellProfiler.
  • Ensure analytical methodologies are scientifically rigorous, reproducible, and fit for purpose.
  • Establish best practices for algorithm validation, quality control, and performance monitoring.
Biomarker Discovery & Translational Research
  • Collaborate with pathology and translational research teams to identify and validate tissue-based biomarkers.
  • Support development of quantitative image analysis methodologies to assess biomarker expression and spatial biology features.
  • Interpret histopathological and computational findings to generate actionable scientific insights.
  • Contribute to translational research strategies that support preclinical and clinical development programs.
Data Integration & Metadata Governance
  • Lead development of metadata ingestion, reconciliation, and data integration strategies supporting digital pathology ecosystems.
  • Oversee implementation of automated workflows that integrate image data, metadata, and analytical outputs into enterprise image management systems.
  • Ensure data integrity, traceability, and compliance with organizational data standards.
  • Collaborate with data engineering and informatics teams to improve data accessibility and analytical efficiency.
Governance, Compliance & Documentation
  • Establish project governance frameworks, including stage gates, milestone reviews, risk management processes, and performance metrics.
  • Ensure all computational methodologies and deliverables are documented according to pharmaceutical industry standards and Good Documentation Practices (GDP).
  • Review and approve technical reports, validation documentation, protocols, and scientific deliverables.
  • Identify project risks and develop mitigation strategies to ensure successful execution.
  • Support audits, inspections, and regulatory inquiries related to computational pathology activities.
Stakeholder Management
  • Partner with pathologists, translational scientists, laboratory teams, bioinformaticians, statisticians, and external vendors.
  • Facilitate regular project review meetings and governance forums.
  • Communicate complex technical concepts to both scientific and non-technical stakeholders.
  • Drive alignment across cross-functional teams to ensure successful project execution.
 
Qualifications:
  • Master's degree or PhD in Computational Biology, Bioinformatics, Biomedical Engineering, Computer Science, Data Science, Pathology, Biostatistics, or related scientific discipline.
  • 10+ years of experience in computational pathology, digital pathology, image analysis, biomarker research, translational medicine, or related disciplines.
  • Minimum 5 years of leadership experience managing multidisciplinary scientific teams and complex research programs.
  • Demonstrated experience supporting pharmaceutical, biotechnology, CRO, or translational research organizations.
  • Experience leading computational pathology initiatives from concept through validation and deployment.
  • Experience managing external vendors, collaborators, and scientific partnerships.
  • Experience with multiplex imaging technologies, immunohistochemistry (IHC), immunofluorescence (IF), and spatial transcriptomics.
  • Knowledge of FDA, GxP, and pharmaceutical research quality standards.
  • Experience working with automated staining platforms such as Ventana Discovery Ultra and Leica Bond RX.
  • Publications, patents, or recognized scientific contributions in computational pathology or digital pathology.

Estimated Min Rate: $70.00
Estimated Max Rate: $100.00
What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:
  • Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
  • Health Savings Account (HSA) (for employees working 20+ hours per week)
  • Life & Disability Insurance (for employees working 20+ hours per week)
  • MetLife Voluntary Benefits
  • Employee Assistance Program (EAP)
  • 401K Retirement Savings Plan
  • Direct Deposit & weekly epayroll
  • Referral Bonus Programs
  • Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.
Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
Visit https://www.yoh.com/applicants-with-disabilities to contact us if you are an individual with a disability and require accommodation in the application process.
For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
By applying and submitting your resume, you authorize Yoh to review and reformat your resume to meet Yoh’s hiring clients’ preferences. To learn more about Yoh’s privacy practices, please see our Candidate Privacy Notice: https://www.yoh.com/privacy-notice

Company Description

Yoh delivers expertise, methodology, and momentum to keep work moving forward. From strategy to execution, we deliver bold ideas and big results through consulting, staffing, and enterprise solutions. Nearly a century after our founding, Yoh remains STEM-centered, collaborative, and committed to client success. Yoh is a proud member of the Day & Zimmermann family of companies. Visit us at https://www.yoh.com/