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The Izzo Lab (Laboratory of Clonal Evolution and Molecular Epigenetics of Cancer) at the Icahn School of Medicine at Mount Sinai is seeking a highly motivated Postdoctoral Fellow in Bioinformatics to join our team. Our research focuses on uncovering the fundamental mechanisms driving the onset, therapy resistance, and progression of hematological malignancies, with a particular emphasis on clonal evolution, genetic heterogeneity, and epigenetic plasticity. We develop and apply cutting-edge single-cell sequencing technologies (including multi-omic approaches integrating genomics, transcriptomics, and epigenomics) to directly profile patient samples. This work aims to map genotype-to-phenotype relationships, understand how somatic mutations drive epigenetic deregulation, and identify vulnerabilities that can be targeted to overcome therapy resistance and improve patient outcomes. The successful candidate will play a central role in the computational analysis of large-scale single-cell datasets from ongoing projects in blood cancers (e.g., myeloproliferative neoplasms, MDS, and leukemia). This is an outstanding opportunity for a computational scientist interested in translational cancer research within a dynamic, collaborative, and highly supportive environment at the Tisch Cancer Institute and Center for Advancement of Blood Cancer Therapies (CABCT).
Responsibilities

• Perform advanced bioinformatics analysis of single-cell multi-omic data (scRNA-seq, scATAC-seq, multiome, CITE-seq, and emerging spatial/single-cell technologies), including quality control, integration, clustering, trajectory inference, and differential analysis.
• Develop and apply custom computational methods or pipelines to study genetic heterogeneity, clonal evolution, somatic mutation effects, and epigenetic regulation (e.g., chromatin accessibility, gene regulatory networks, and plasticity).
• Integrate multi-modal datasets with clinical and functional data to generate biological insights and hypotheses.
• Collaborate closely with wet-lab team members on experimental design, data interpretation, and validation.
• Contribute to manuscript preparation, grant writing, and presentation of findings at conferences.
• Mentor junior lab members and participate in lab meetings and journal clubs.

Qualifications

• Ph.D. (or M.D./Ph.D.) in Bioinformatics, Computational Biology, Genomics, Biostatistics, or a closely related field.
• Strong expertise in single-cell sequencing analysis, with demonstrated experience in R/Bioconductor and/or Python (e.g., Seurat, Scanpy, ArchR, Signac, or similar tools).
• Proficiency in handling large-scale genomic datasets, statistical modeling, machine learning (optional but a plus), and high-performance computing (e.g., SLURM clusters).
• Familiarity with cancer biology, epigenetics, or clonal evolution is highly desirable.
• Excellent communication skills, ability to work independently and in teams, and a track record of peer-reviewed publications.
• Prior experience with hematological malignancies or multi-omic integration is a strong advantage.

What We Offer

• Competitive salary and benefits, commensurate with experience and NIH guidelines (including subsidized housing options in New York City).
• Access to state-of-the-art computational resources and core facilities at Mount Sinai.
• Mentorship from Dr. Franco Izzo and close collaboration with leading investigators in oncology, single-cell genomics, and hematology.
• Opportunities for career development, including independent projects, grant applications (e.g., K99/R00), and networking within the vibrant Mount Sinai research community.
• A creative, rigorous, and supportive lab culture focused on high-impact science with translational potential.

How to Apply
Interested candidates should send the following to franco.izzo@mssm.edu (mailto:franco.izzo@mssm.edu)(with the subject line ?Postdoc Bioinformatics Application ? [Your Last Name]?):

• Cover letter describing research interests, relevant experience, and career goals.
• Curriculum vitae (CV).
• Contact information for 2?3 references.
• One representative publication (PDF).

Applications will be reviewed on a rolling basis until the position is filled. Mount Sinai is an equal opportunity employer; we encourage applications from diverse backgrounds.
SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 824 - Oncological Sciences - ISM, Icahn School of Medicine
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Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's "Best Children's Hospitals" ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's "The World's Best Smart Hospitals" ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
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The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.