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How much do plasmid jobs pay per hour?

As of May 29, 2026, the average hourly pay for plasmid in the United States is $33.68, according to ZipRecruiter salary data. Most workers in this role earn between $27.64 and $41.35 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Plasmid Scientist, and why are they important?

To excel as a Plasmid Scientist, you need a solid background in molecular biology, genetics, and biochemistry, typically supported by a relevant degree (such as a BSc, MSc, or PhD) in life sciences. Experience with techniques like PCR, DNA cloning, gel electrophoresis, and proficiency in using laboratory information management systems (LIMS) are commonly required, along with familiarity with tools like CRISPR and plasmid design software. Strong attention to detail, problem-solving abilities, and clear scientific communication skills are critical for success in this role. These skills ensure accurate plasmid construction, data integrity, and effective collaboration within research teams.

What are some common challenges faced by scientists working with plasmids in a laboratory setting?

Scientists handling plasmids often encounter challenges such as ensuring the purity and quality of plasmid DNA, optimizing transformation efficiency, and preventing contamination. Troubleshooting issues like low plasmid yield or unwanted mutations requires attention to protocol details and familiarity with molecular biology techniques. Collaborating closely with team members, such as research associates and lab technicians, is essential for coordinating experiments and sharing best practices, especially in high-throughput or collaborative research environments.

What are plasmids?

Plasmids are small, circular pieces of double-stranded DNA that exist independently of the chromosomal DNA in bacteria and some other cells. They often carry genes that provide beneficial traits, such as antibiotic resistance or the ability to metabolize unusual substances. Plasmids are widely used in genetic engineering and biotechnology as vectors to introduce foreign genes into host organisms. Their ability to replicate independently makes them valuable tools for cloning and gene expression studies.

What is the difference between Plasmid vs Molecular Biologist?

AspectPlasmidMolecular Biologist
Required CredentialsLaboratory skills, molecular biology knowledge, often a degree in biology or related fieldDegree in biology, biochemistry, or related field; often advanced degrees
Work EnvironmentResearch labs, biotech companies, academic institutionsResearch labs, academic settings, biotech firms
Employer & Industry UsageUsed in genetic engineering, cloning, and researchConducts research, experiments, and data analysis in molecular biology

While a plasmid is a DNA molecule used as a tool in genetic engineering, a molecular biologist is a professional who studies biological processes at the molecular level. Both roles often work in research labs and require knowledge of molecular biology techniques, but plasmids are tools, whereas molecular biologists are researchers who utilize such tools to conduct experiments and advance scientific understanding.

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What job categories do people searching Plasmid jobs look for? The top searched job categories for Plasmid jobs are:
Plasmid jobs near you
Infographic showing various Plasmid job openings in the United States as of May 2026, with employment types broken down into 50% Full Time, and 50% Contract. Highlights an 100% In-person job distribution, with an average salary of $70,060 per year, or $33.7 per hour.

Molecular Biology/Plasmid Constructs Co-Op

Legend Biotech US

Philadelphia, PA

Other

Posted yesterday

Job description

Legend Biotech is seeking a Molecular Biology/Plasmid Constructs Co-Op as part of the R&D team based in Philadelphia, PA.

Role Overview

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse range of technology platforms, including autologous and allogeneic chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapies. From our global R&D sites, we leverage innovative technologies to advance the discovery and development of safe, effective, and cutting-edge therapies for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autoleucel (cilta-cel). This strategic partnership combines the strengths and expertise of both companies to advance the promise of immunotherapy for the treatment of multiple myeloma.

The Philadelphia R&D site continues to expand its research capabilities, including growing capacity to support in-vivo CAR-T discovery and vector biology research, spanning early process development and platform optimization, to advance next-generation cell and gene therapy innovation.

The Molecular Biology team within the Vector Biology group at Legend Biotech's Philadelphia R&D facility is seeking a motivated Molecular Biology Co-Op who is currently pursuing a Master's or PhD degree in Molecular Biology, Cell Biology, Biotechnology, or a related life science discipline.

The Co-Op will support lentiviral vector (LVV) design, plasmid construction, and functional evaluation to advance in-vivo CAR-T programs. This role provides hands-on experience with molecular biology techniques, viral vector technologies, and mammalian cell engineering in a collaborative industry research environment.

Co-Op Duration: 6-month (Summer to Fall) with possible extension.

Key Responsibilities

  • Assist with plasmid cloning workflows, including PCR, restriction digestion, ligation, bacterial transformation, and plasmid preparation.
  • Support viral vector plasmid and helper plasmid construction for gene expression and vector development studies.
  • Confirm plasmid constructs through restriction digest analysis and sequencing review.
  • Maintain accurate plasmid records, including sequence files, plasmid maps, inventory tracking, and documentation.
  • Perform mammalian cell culture and transient transfection under BSL-2 conditions.
  • Support small-scale lentiviral vector production and preparation of samples for downstream characterization.
  • Assist with molecular and cellular assays used to evaluate vector performance, such as qPCR/ddPCR, ELISA, Western blot, and flow cytometry.
  • Document experimental procedures and results in electronic lab notebooks in accordance with company policies and laboratory standards.
  • Follow BSL-2 biosafety practices and maintain compliance with laboratory safety guidelines.
Requirements
  • Currently pursuing a Master's or PhD degree in Molecular Biology, Cell Biology, Virology, Biotechnology, or a related life science discipline.
  • Hands-on experience with molecular cloning, plasmid preparation, PCR, or DNA assembly methods.
  • Experience with mammalian cell culture and transfection is preferred.
  • Familiarity with viral vector systems, gene delivery technologies, or cell therapy research is a plus.
  • Strong analytical, organizational, and problem-solving skills.
  • Ability to work effectively in a collaborative research environment and communicate scientific results clearly.
  • Experience with mammalian cell culture and transfection.
  • Familiarity with viral vector systems, gene delivery technologies, or cell therapy research.
  • Basic knowledge of molecular and cellular assays, including qPCR, ELISA, or flow cytometry.
  • Strong organizational and communication skills. 

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