ZipRecruiter

Log In

1

Plasmid Jobs (NOW HIRING)

System One

Biochemist/Molecular Biologist

Cambridge, MA · On-site

$35 - $41.82/hr

Responsibilities • Independently execute high-throughput plasmid DNA production workflows including bacterial culture, plasmid purification, and downstream sample handling • Operate and ...

System One

Biochemist/Molecular Biologist

Cambridge, MA · On-site

$35 - $41.82/hr

Responsibilities • Independently execute high-throughput plasmid DNA production workflows including bacterial culture, plasmid purification, and downstream sample handling • Operate and ...

next page

Showing results 1-20

All JobsPlasmid Jobs

Plasmid information

See salary details

$18

$33

$49

How much do plasmid jobs pay per hour?

As of Jul 4, 2026, the average hourly pay for plasmid in the United States is $33.68, according to ZipRecruiter salary data. Most workers in this role earn between $27.64 and $41.35 per hour, depending on experience, location, and employer.

What is the job of plasmids?

In a biological research or biotechnology context, the job of plasmids is to serve as small, circular DNA molecules that can replicate independently within a host cell. They are used as vectors to transfer genetic material, enable gene cloning, and produce proteins in laboratory and industrial applications.

What are the key skills and qualifications needed to thrive as a Plasmid Scientist, and why are they important?

To excel as a Plasmid Scientist, you need a solid background in molecular biology, genetics, and biochemistry, typically supported by a relevant degree (such as a BSc, MSc, or PhD) in life sciences. Experience with techniques like PCR, DNA cloning, gel electrophoresis, and proficiency in using laboratory information management systems (LIMS) are commonly required, along with familiarity with tools like CRISPR and plasmid design software. Strong attention to detail, problem-solving abilities, and clear scientific communication skills are critical for success in this role. These skills ensure accurate plasmid construction, data integrity, and effective collaboration within research teams.

What careers are in cell biology?

Careers in cell biology include roles such as research scientist, laboratory technician, and university professor, focusing on understanding cell functions and processes. These positions often require a degree in biology or a related field, proficiency with laboratory techniques, and knowledge of microscopy and molecular biology tools.

What is the difference between Plasmid vs Molecular Biologist?

AspectPlasmidMolecular Biologist
Required CredentialsLaboratory skills, molecular biology knowledge, often a degree in biology or related fieldDegree in biology, biochemistry, or related field; often advanced degrees
Work EnvironmentResearch labs, biotech companies, academic institutionsResearch labs, academic settings, biotech firms
Employer & Industry UsageUsed in genetic engineering, cloning, and researchConducts research, experiments, and data analysis in molecular biology

While a plasmid is a DNA molecule used as a tool in genetic engineering, a molecular biologist is a professional who studies biological processes at the molecular level. Both roles often work in research labs and require knowledge of molecular biology techniques, but plasmids are tools, whereas molecular biologists are researchers who utilize such tools to conduct experiments and advance scientific understanding.

What are plasmids?

Plasmids are small, circular pieces of double-stranded DNA that exist independently of the chromosomal DNA in bacteria and some other cells. They often carry genes that provide beneficial traits, such as antibiotic resistance or the ability to metabolize unusual substances. Plasmids are widely used in genetic engineering and biotechnology as vectors to introduce foreign genes into host organisms. Their ability to replicate independently makes them valuable tools for cloning and gene expression studies.

What is a plasmid in biotechnology?

A plasmid is a small, circular DNA molecule commonly used in biotechnology for gene cloning and genetic modification. It can replicate independently within a host cell, such as bacteria, and is often introduced into cells using techniques like transformation or electroporation. Working with plasmids requires knowledge of molecular biology tools and sterile laboratory practices.

What are some common challenges faced by scientists working with plasmids in a laboratory setting?

Scientists handling plasmids often encounter challenges such as ensuring the purity and quality of plasmid DNA, optimizing transformation efficiency, and preventing contamination. Troubleshooting issues like low plasmid yield or unwanted mutations requires attention to protocol details and familiarity with molecular biology techniques. Collaborating closely with team members, such as research associates and lab technicians, is essential for coordinating experiments and sharing best practices, especially in high-throughput or collaborative research environments.
More about Plasmid jobs
What job categories do people searching Plasmid jobs look for? The top searched job categories for Plasmid jobs are:
Plasmid jobs near you
Infographic showing various Plasmid job openings in the United States as of June 2026, with employment types broken down into 96% Full Time, 2% Part Time, and 2% Contract. Highlights an 95% Physical, and 5% Remote job distribution, with an average salary of $70,060 per year, or $33.7 per hour.
Research Associate - GEM Plasmid Production Facility

Research Associate - GEM Plasmid Production Facility

Roswell Park Comprehensive Cancer Center

Buffalo, NY • On-site

$59K/yr

Full-time

Posted 12 days ago

Roswell Park Comprehensive Cancer Center rating

8.1

Company rating: 8.1 out of 10

Based on 18 frontline employees who took The Breakroom Quiz

Job description

Title:
Research Associate - GEM Plasmid Production Facility
Job Type:
RegularCompany:
Health Research, Inc. (HRI) Roswell Park DivisionDepartment:
Center for ImmunotherapyTime Type:
Full timeWeekly Hours:
40
FTE:
1Shift:
First Shift (United States of America)
Summary:
The Research Associate will support the development and production of research- and GMP-grade plasmid DNA within the Plasmid Production Facility. This role will focus on molecular cloning, construct design, and upstream/downstream process development to enable robust, scalable, and regulatory compliant plasmid manufacturing in support of cell and gene therapy programs.
The ideal candidate has strong bench skills in molecular biology and cloning, experience with bacterial expression systems, and an interest in translating laboratory methods into standardized, phase-appropriate manufacturing processes.
Key Responsibilities
Molecular Cloning and Construct Development
• Design and generate plasmid constructs for use in GMP plasmid production
• Perform routine and advanced molecular biology techniques, including:
oDNA isolation and purification
oPCR and qPCR
oRestriction digestion and ligation
oColony screening and clone verification
• Interpret sequencing and analytical data to select and document final plasmid constructs.
• Maintain detailed records of plasmid maps, sequences, and lineage in electronic systems.
Process Development (Upstream and Downstream)
• Support development and optimization of plasmid production processes in E. coli, including:
oStrain selection and characterization
oShake flask and bioreactor growth studies
oMedia and feed strategy optimization
oInduction and harvest parameters
• Assist with downstream process development for plasmid purification, including clarification, chromatography, precipitation, filtration, and concentration steps.
• Perform small-scale and scale-down studies to evaluate process robustness, yield, and product quality attributes.
• Analyze process data and contribute to development reports, technology transfer documents, and batch records.
GMP Readiness and Laboratory Operations
• Execute studies and experiments following written procedures, development protocols, and applicable quality standards.
• Draft and review technical documents such as standard operating procedures (SOPs), test methods, and development reports.
• Support the transition of processes into GMP operations by contributing to process descriptions, risk assessments, and tech transfer packages.
• Maintain laboratory equipment, inventory, and general lab organization in collaboration with the broader team.
• Adhere to safety guidelines and maintain compliance with institutional biosafety and quality policies.
Cross-functional Collaboration
• Work closely with Quality Control, Quality Assurance, and other GEM staff to ensure process alignment and manufacturability.
• Participate in team meetings to present data, troubleshoot issues, and propose improvements.
• Support investigations, deviations, and continuous improvement initiatives related to plasmid process performance and quality.
The starting salary for this position is $59,537 and this includes a full comprehensive benefits package.
Qualifications:
Required Education and Experience
1. Master's degree and the equivalent of eighteen (18) months of full-time professional research experience in a laboratory, clinical or scientific research environment; or
2. Bachelor's degree and the equivalent of thirty (30) months of full-time professional research experience in a laboratory, clinical or scientific research environment.
NOTE:
Required degrees must have been granted by an accredited school, college or university or one recognized by Roswell Park Comprehensive Cancer Center as following acceptable educational practices.
  • 2-3 years of hands-on industry experience in biopharmaceuticals, synthetic biology, molecular biology, or plasmid production.
  • Experience working in a GMP, GLP, or similarly regulated environment (even academic GMP or process development labs).
  • Strong proficiency in molecular cloning, including seamless/Gibson cloning, Golden Gate, or other assembly methods.
  • Experience with E. coli-based plasmid production, including shake flask and (ideally) small bioreactor work.
  • Familiarity with downstream plasmid purification
  • Experience with analytical QC methods such as qPCR, agarose gel electrophoresis, HPLC/UPLC, endotoxin testing, or OD600-based growth monitoring.
  • Experience writing or revising SOPs, batch records, development reports, or deviation/investigation documents.
  • Understanding of cGMP principles, data integrity, and phase-appropriate documentation.

Equal Employment Opportunity Statement
Roswell Park Cancer Institute Corporation (RPCIC) and Health Research Inc. (HRI) Roswell Park Division believe that all persons are entitled to equal employment opportunities, and we do not discriminate against our employees, applicants or job seekers because of their race, color, religion, sex, sexual orientation, gender identity or expression, national origin, creed, age, disability, pregnancy-related condition, military or veteran status, marital or familial status, domestic violence victim status, citizenship status, genetic information, individual's relationship or association with a member of a protected category or any other protected group status as defined by law.
Affirmative Action/Equal Opportunity Employer/Qualified Individuals with Disabilities/Qualified Protected Veterans
Reasonable Accommodation Request
RPCIC and HRI are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email HR-PayAndBenefits@RoswellPark.org and let us know the nature of your request and your contact information.
Our Core Values
RPCIC and HRI are committed to providing an environment where patients, families, employees and community are treated with courtesy and respect. We support an inclusive environment that nurtures the talents, skills and abilities of each individual to embody and reflect our core values: Innovation, Integrity, Teamwork, Commitment, Compassion and Respect.
Grant Funding
This is a grant-funded position. Compliance with funding requirements such as time and effort reporting, grant deliverables, and contract deliverables is required.
E-Verify Employer
Health Research Inc. (HRI) Roswell Park Division participates in the E-Verify program.

What Roswell Park Comprehensive Cancer Center employees say

Pay

Benefits

Hours and flexibility

Workplace

Get the full story on Breakroom

Apply