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Patch Clamp Jobs (NOW HIRING)

University of Florida

Post Doctoral Associate

Gainesville, FL · On-site

$44K - $60K/yr

... patch-clamp electrophysiology, optogenetics and chemogenetics, spatial transcriptomics, and 3D imaging. We are interested in the role of serotonin systems in the pathogenesis of Alzheimer's disease ...

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How much do patch clamp jobs pay per week?

As of Jul 21, 2026, the average weekly pay for patch clamp in the United States is $1,444.35, according to ZipRecruiter salary data. Most workers in this role earn between $1,250.00 and $1,625.00 per week, depending on experience, location, and employer.

What are some typical daily responsibilities for someone working in a Patch Clamp role?

A Patch Clamp professional’s daily responsibilities often include preparing biological samples or cultured cells, setting up and calibrating electrophysiology equipment, and performing precise patch clamp recordings to study ion channel activity. Data analysis, troubleshooting technical issues, and maintaining detailed experimental records are also common tasks. Collaboration with other researchers, attending lab meetings, and contributing to manuscript preparation or grant proposals are frequently part of the role. These varied responsibilities help ensure high-quality scientific outcomes and ongoing professional development within the research team.

What is a Patch Clamp job?

A Patch Clamp job typically involves using the patch-clamp technique to study ion channels in biological cells. This role is common in neuroscience, electrophysiology, and pharmaceutical research, where scientists analyze electrical activity in neurons or other cells. Responsibilities may include preparing cell samples, performing recordings, analyzing data, and maintaining laboratory equipment. Professionals in this field often work in academic institutions, biotechnology companies, or pharmaceutical industries to support drug discovery and fundamental research.

What are the key skills and qualifications needed to thrive in the Patch Clamp position, and why are they important?

To thrive as a Patch Clamp technician or researcher, you typically need a strong background in cellular physiology, electrophysiology, and hands-on laboratory skills, often supported by a relevant degree in biology, neuroscience, or a related field. Proficiency with patch clamp amplifiers, data acquisition software (such as pCLAMP), and microscopy is essential, and additional certifications in laboratory safety are beneficial. Attention to detail, problem-solving abilities, and effective teamwork are key soft skills that help individuals excel in this meticulous and collaborative research environment. These competencies are crucial to ensure reliable data collection, accurate interpretation of experimental results, and smooth collaboration within interdisciplinary scientific teams.

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Patch Clamp jobs near you
Infographic showing various Patch Clamp job openings in the United States as of July 2026, with employment types broken down into 92% Full Time, 2% Part Time, 1% Temporary, 2% Contract, and 3% Nights. Highlights an 100% Physical job distribution, with an average salary of $75,106 per year, or $36.1 per hour.
Principal Scientist, Epilepsy Research

Principal Scientist, Epilepsy Research

The Jackson Laboratory

Bar Harbor, ME • On-site

Full-time

Medical, Dental, Vision, PTO

Posted 26 days ago

The Jackson Laboratory rating

8.3

Company rating: 8.3 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

28th of 105 rated laboratories

Job description

In Vivo Research & Mouse Models
  • Design, execute, and lead seizure studies using established and novel mouse models of epilepsy (e.g., kainate, pilocarpine, kindling, genetic models such as Scn1a+/-).
  • Plan and perform chronic in vivo electrophysiological recordings (EEG/LFP) to quantify seizure burden, inter-ictal activity, and network dynamics.
  • Oversee surgical implantation of recording electrodes and manage long-term telemetric monitoring cohorts.
  • Develop and validate new in vivo model systems relevant to drug-resistant or pediatric epilepsies.

Ex Vivo Electrophysiology
  • Execute and lead acute and organotypic brain slice preparation with high reproducibility across hippocampal, cortical, and thalamocortical circuits.
  • Perform whole-cell patch-clamp and field potential recordings to characterize intrinsic neuronal excitability, synaptic transmission, and network-level epileptiform activity.
  • Analyze pharmacological modulation of ion channels, GABAergic/glutamatergic systems, and other therapeutic targets in slice preparations.

Therapeutic Development
  • Serve as the primary electrophysiology lead in evaluating candidate therapeutics (small molecules, biologics, gene therapy approaches) across preclinical models.
  • Design and execute dose-response, time-course, and mechanistic studies to characterize compound efficacy and tolerability in the CNS.
  • Partner closely with medicinal chemistry, pharmacology, and translational teams to align preclinical findings with clinical hypotheses.
  • Contribute to IND-enabling studies and regulatory submissions by providing high-quality preclinical data packages.

Scientific Leadership & Collaboration
  • Lead a small team of research scientists and associates, providing mentorship, experimental guidance, and career development support.
  • Define research priorities, drive experimental strategy, and ensure rigorous, reproducible science across the team.
  • Present findings at internal research reviews, external conferences, and in peer-reviewed publications.
  • Build and maintain collaborations with academic KOLs, clinical epileptologists, and external research partners.
  • Contribute to grant writing, scientific communications, and IP generation as appropriate.

Required Qualifications
  • PhD in Neuroscience, Pharmacology, Physiology, or a closely related discipline.
  • Minimum 8 years of post-doctoral research experience, with a demonstrated track record in epilepsy or seizure biology.
  • Expert-level proficiency in in vivo electrophysiology, including EEG recording and analysis in rodent seizure models.
  • Expert-level proficiency in brain slice preparation and patch-clamp or field potential electrophysiology.
  • Extensive hands-on experience with rodent models of epilepsy and associated surgical, behavioral, and data analysis workflows.
  • Direct experience contributing to preclinical therapeutic development programs, including target validation and compound profiling.
  • Strong publication record in peer-reviewed journals relevant to epilepsy, ion channel biology, or CNS pharmacology.
  • Demonstrated ability to independently design, execute, and interpret complex experiments and communicate findings clearly.

Preferred Qualifications
  • Experience with genetic mouse models of epilepsy (e.g., Dravet syndrome, KCNQ2, CDKL5).
  • Familiarity with advanced imaging modalities (e.g., calcium imaging, optogenetics) in the context of seizure research.
  • Experience with translational biomarker development or clinical EEG interpretation.
  • Prior experience in a biotech, pharma, or translational research environment.
  • Familiarity with regulatory expectations for preclinical CNS packages (FDA/EMA guidelines).
  • Experience with gene therapy or RNA-based therapeutic modalities.

Skills & Competencies
  • Scientific rigor and meticulous attention to reproducibility and data quality.
  • Strong analytical and quantitative skills; proficiency with electrophysiology analysis software (e.g., Clampfit, Spike2, custom MATLAB/Python pipelines).
  • Excellent written and verbal communication skills, including the ability to present complex data to cross-functional stakeholders.
  • Collaborative mindset with the ability to work effectively across disciplines and organizational boundaries.
  • Self-motivated, proactive, and capable of managing multiple priorities in a fast-paced research environment.
  • Demonstrated leadership ability, including mentoring junior scientists and driving team-level deliverables.

What We Offer
  • A senior, high-visibility role at the forefront of epilepsy research and drug discovery.
  • Significant scientific autonomy and the opportunity to shape the direction of a core research program.
  • A collaborative, mission-driven culture with access to state-of-the-art research infrastructure.
  • Competitive compensation package including base salary, bonus, and equity.
  • Comprehensive benefits including medical, dental, vision, and generous PTO.
  • Support for conference attendance, publications, and continued professional development.

Knowledge, Skills, and Abilities
  • A Ph.D. or equivalent degree in a relevant scientific field
  • Extensive experience (typically 8+ years) in scientific research, preferably in a related industry or academic setting.
  • Proven track record of leading successful research projects, with a strong publication record and demonstrated expertise in a specialized area.
  • Proficiency in experimental design, data analysis, and interpretation.
  • Excellent leadership, communication, and interpersonal skills.
  • Ability to thrive in a dynamic, fast-paced environment and effectively manage multiple projects simultaneously.
  • Familiarity with regulatory guidelines and compliance requirements relevant to the industry.

Education: Doctorate required/preferred
Experience: 8 years required/ 10 years preferred
Pay Range: $136,461 - $212,147, salary is determined by experience
About JAX:
The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org.
EEO Statement:
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

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