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Overnight Histotechnologist Jobs (NOW HIRING)

We are currently seeking an overnight Histotechnologist to join our Immunohistochemistry team . Role Overview The IHC Histotechnologist will support daily Immunohistochemistry laboratory operations ...

$41.28 - $57.11/hr

Overnight shift * 50% admin and 50% bench work * No weekends * Benefit-eligible position Provides ... such as Histotechnologist (HTL), or Cytotechnologist (CT) upon hire required Physical Demands

Overnight Histotechnologist information

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$30.5K

$80K

$112.5K

How much do overnight histotechnologist jobs pay per year?

As of Jul 28, 2026, the average yearly pay for overnight histotechnologist in the United States is $80,005.00, according to ZipRecruiter salary data. Most workers in this role earn between $63,000.00 and $102,500.00 per year, depending on experience, location, and employer.

What is an Overnight Histotechnologist?

An Overnight Histotechnologist is a laboratory professional who prepares tissue samples for microscopic examination, typically working night shifts in hospitals or diagnostic labs. Their duties include sectioning, staining, and mounting tissue specimens to assist pathologists in diagnosing diseases. Working overnight ensures that specimens are ready for analysis by the next day, supporting quick turnaround times for critical patient diagnoses.

What are some unique challenges of working as an Overnight Histotechnologist, and how can I prepare for them?

Working as an Overnight Histotechnologist often involves operating with limited supervision and handling urgent or stat cases that require quick turnaround times. You may also be responsible for troubleshooting equipment issues and ensuring that all specimens are processed accurately before the morning shift arrives. To prepare, it's helpful to develop strong independent problem-solving skills, maintain excellent attention to detail, and be comfortable working in a quieter, less populated lab environment. Good communication with day shift staff is also essential for smooth handoffs and continuity of patient care.

What are the key skills and qualifications needed to thrive as an Overnight Histotechnologist, and why are they important?

To excel as an Overnight Histotechnologist, you need in-depth knowledge of tissue processing, embedding, microtomy, and staining, typically supported by an associate's or bachelor's degree in histotechnology or a related field and HT/HTL (ASCP) certification. Proficiency with laboratory information systems (LIS), automated stainers, and quality control protocols is essential. Attention to detail, strong time management, and the ability to work independently are crucial soft skills for success during overnight shifts. These competencies ensure accurate and timely diagnostic results, supporting effective patient care even outside regular hours.

What is the difference between Overnight Histotechnologist vs Histotechnician?

AspectOvernight HistotechnologistHistotechnician
CredentialsASCP certification often preferred, relevant education in histotechnologyTypically requires a histotechnology certificate or associate degree
Work EnvironmentHospitals, laboratories, often overnight shiftsPathology labs, hospitals, usually daytime shifts
Job ResponsibilitiesPreparing tissue samples, complex staining, quality controlAssisting with tissue processing, basic slide preparation

The Overnight Histotechnologist and Histotechnician roles both involve tissue sample preparation, but the histotechnologist typically handles more complex tasks and requires advanced certification. The histotechnologist often works overnight in hospital labs, while the histotechnician usually works during daytime hours. Both roles are essential in pathology labs, with the histotechnologist generally performing more advanced procedures.

More about Overnight Histotechnologist jobs
What cities are hiring for Overnight Histotechnologist jobs? Cities with the most Overnight Histotechnologist job openings:
What are the most commonly searched types of Histotechnologist jobs? The most popular types of Histotechnologist jobs are:
What states have the most Overnight Histotechnologist jobs? States with the most job openings for Overnight Histotechnologist jobs include:
What job categories do people searching Overnight Histotechnologist jobs look for? The top searched job categories for Overnight Histotechnologist jobs are:
Infographic showing various Overnight Histotechnologist job openings in the United States as of July 2026, with employment types broken down into 7% Locum Tenens, 1% Internship, 1% As Needed, 38% Full Time, 3% Part Time, and 50% Temporary. Highlights an 100% Physical job distribution, with an average salary of $80,005 per year, or $38.5 per hour.

Immunohistochemistry Histotechnologist

Msk

New York, NY

$46.26 - $74/hr

Full-time

Posted 3 days ago


Job description

About Us:

The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursueour missionat MSK and around the globe.

Exciting Opportunity: We are currently seeking an overnight Histotechnologist to join our Immunohistochemistry team.

Role Overview

The IHC Histotechnologist will support daily Immunohistochemistry laboratory operations, including specimen preparation, technical testing, quality control, instrument maintenance, troubleshooting, validation, and compliance with regulatory and departmental requirements.

Responsibilities include:

  • Section paraffin tissue specimens as requested.

  • Perform Immunohistochemistry techniques, including embedding, microtomy, tissue processing, reagent preparation, antibody staining, and antibody reactivity review.

  • Perform and document IHC quality control activities according to laboratory procedures.

  • Assist with IHC instrument maintenance, including daily setup, shutdown, cleaning, routine maintenance, and troubleshooting.

  • Analyze and troubleshoot equipment-related, staining-related, reagent-related, and workflow-related issues in a timely manner.

  • Assist with lot-to-lot validation, antibody validation, optimization, and troubleshooting.

  • Maintain accurate quality control, quality assurance, validation, and maintenance records.

  • Support compliance with FDA, CAP/CLIA, NYS, and Joint Commission requirements.

  • Adapt to updated workflows, procedures, and operational changes with an open mind and in a timely manner.

  • Work collaboratively with supervisors, leads, pathologists, and team members to support patient care, laboratory quality, and turnaround time.

Key Qualifications

  • Bachelor's degree or equivalent in Medical Technology, Clinical Laboratory Science, Biology, Chemistry, or a related field.

  • NYS Clinical Laboratory Technologist license, Certified Histological Technologist license, or eligibility to obtain NYS licensure required.

  • Prior experience in Histology and/or Immunohistochemistry is strongly preferred.

Core Skills

  • Knowledge of instruments used in Immunohistochemistry.

  • Knowledge of Immunohistochemistry antibodies, staining patterns, and antibody reactivity.

  • Ability to perform dilutions and laboratory calculations accurately.

  • Ability to assist with antibody optimization, validation, lot-to-lot validation, and troubleshooting.

  • Ability to perform IHC quality control and maintain complete documentation.

  • Ability to perform routine IHC instrument maintenance and recognize instrument-related issues.

  • Strong troubleshooting skills related to staining quality, instrument function, reagents, and workflow.

  • Excellent organizational and time-management skills.

  • Strong digital literacy, including working with laboratory databases and computer systems.

  • Strong problem-solving skills, with the ability to manage complex, high-volume, and sometimes conflicting information effectively.

  • Good decision-making skills, with proven ability to make timely decisions that support laboratory operations.

  • Commitment to compliance with FDA, CAP/CLIA, NYS, and Joint Commission regulations.

  • Open-minded and flexible with updated workflows, process improvements, and operational changes.

  • Eager to take on new opportunities and challenging assignments with urgency, high energy, and enthusiasm.

Additional Information

  • Schedule: Sunday through Thursday, 9:00 PM to 5:00 AM, 100% onsite.

  • Location: Main Hospital Campus, 1275 York Avenue, New York, NY.

  • Reporting to: IHC Assistant Manager.

Differential: 10% overnight differential & additional 10% differential for Sundays (20%!)

Helpful Links:

  • Compensation Philosophy

  • Benefits

Pay Range: $46.26 - $74.00FSLA Status: Non-Exempt

Closing:

At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills.

MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.