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Oligonucleotides Jobs (NOW HIRING)

Dyne Therapeutics

Scientist, RNA Chemistry

Waltham, MA · On-site

$118K - $145K/yr

Independently perform synthesis of modified RNA oligonucleotides (ASO, siRNAs) incorporating diverse sugar and backbone chemistries at scales suitable for both in vitro and in vivo studies.

Roche

Scientist

Pleasanton, CA · On-site

$111K - $206K/yr

You will synthesize, purify, characterize complex nucleotides, phosphoramidites, oligonucleotides, their analogs, and related small molecule reagents. You will drive process optimization to enable ...

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Oligonucleotides information

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How much do oligonucleotides jobs pay per hour?

As of Jul 13, 2026, the average hourly pay for oligonucleotides in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Oligonucleotide Scientist, and why are they important?

To thrive as an Oligonucleotide Scientist, you need a solid background in molecular biology, organic chemistry, and nucleic acid synthesis, typically supported by an advanced degree in a relevant scientific field. Familiarity with automated oligonucleotide synthesizers, analytical instruments like HPLC and mass spectrometry, and software for sequence design is essential. Strong problem-solving abilities, attention to detail, and effective teamwork are valuable soft skills in this role. These competencies are critical for ensuring high-quality synthesis, accurate analysis, and successful collaboration in research or pharmaceutical environments.

What is the difference between Oligonucleotides vs Molecular Biologists?

AspectOligonucleotides

Oligonucleotides are short DNA or RNA sequences used in genetic research, diagnostics, and therapeutics. Molecular biologists design, synthesize, and analyze these sequences as part of their work. While oligonucleotides are tools or materials, molecular biologists are professionals who perform experiments, interpret data, and develop applications involving these molecules. Both roles often require knowledge of molecular biology techniques, but oligonucleotides are specific products, whereas molecular biologists are researchers or scientists in the field.

What are oligonucleotides?

Oligonucleotides are short sequences of nucleotides, typically composed of DNA or RNA, that are synthesized to have a specific sequence of bases. They are widely used in molecular biology research, diagnostics, and therapeutic applications, such as PCR primers, probes, and antisense therapies. Oligonucleotides can be custom-made to target specific genes, making them valuable tools in genetic testing, gene editing, and drug development.

What are some common challenges faced by professionals working in oligonucleotide synthesis and how can they be addressed?

Professionals in oligonucleotide synthesis often encounter challenges such as maintaining high purity and yield, troubleshooting synthesis failures, and working with sensitive reagents or complex modifications. Addressing these challenges requires strong attention to detail, familiarity with automated synthesizers, and staying updated on best practices for purification and quality control. Collaborating closely with analytical teams and participating in ongoing training can also help resolve technical issues efficiently and ensure the delivery of high-quality oligonucleotides for research or therapeutic use.
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Oligonucleotides jobs near you
Infographic showing various Oligonucleotides job openings in the United States as of July 2026, with employment types broken down into 99% Full Time, and 1% Part Time. Highlights an 91% Physical, 4% Hybrid, and 5% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.
Scientist II - Oligonucleotides

Scientist II - Oligonucleotides

Dawar Consulting, Inc.

South San Francisco, CA

$47 - $53/hr

Full-time

Posted 16 days ago

Job description

Our client, leading leader in biotechnology and diagnostics, is looking for Scientist II - Oligonucleotides based out of South San Francisco. If you are interested to discuss further, please review the details below.


Duration: Long term contract (Possibility of further extension)

Pay Rate: $53.50/hr on W2


Job Summary:


We are seeking a motivated Oligonucleotide Scientist II to support oligonucleotide therapeutic discovery within a collaborative drug discovery team. The successful candidate will have hands-on experience in oligonucleotide synthesis, purification, and characterization, and will contribute to the development of RNA-based therapeutics across neuroscience, oncology, and immunology programs.
Responsibilities
  • Perform hands-on synthesis, purification, and characterization of oligonucleotides using automated synthesizers, HPLC, and mass spectrometry.
  • Develop, optimize, and troubleshoot oligonucleotide synthesis methods, including impurity profiling and process improvements.
  • Collaborate with cross-functional research teams to support oligonucleotide therapeutic discovery and lead molecule progression.
  • Operate, maintain, and troubleshoot laboratory equipment including oligo synthesizers, HPLC systems, and desalting units.
  • Execute nucleic acid chemistry experiments, analyze data, maintain laboratory documentation, and support scale-up synthesis for preclinical studies.
  • Conduct literature reviews and contribute to experimental planning, scientific discussions, and project presentations.
  • Maintain high laboratory productivity while adhering to safety and quality standards.
Required Qualifications
  • BS or MS in Organic Chemistry, Medicinal Chemistry, Biochemistry, Chemical Biology, or a related scientific discipline.
  • Hands-on experience with automated oligonucleotide synthesis.
  • Experience with HPLC purification and mass spectrometry for oligonucleotide characterization.
  • Knowledge of nucleic acid chemistry and oligonucleotide synthesis workflows.
  • Strong analytical, troubleshooting, organizational, and communication skills.
  • Ability to work independently and collaboratively in a fast-paced research environment.
Preferred Qualifications
  • Experience in RNAi therapeutics, antisense oligonucleotides (ASO), or nucleic acid therapeutics.
  • Experience with large molecule drug discovery, oligonucleotide delivery, or bioconjugation.
  • Knowledge of sequence design, nucleic acid modifications, and therapeutic mechanisms of action.
  • Pharmaceutical or biotechnology industry experience in oligonucleotide drug discovery.
  • Experience supporting preclinical research and scale-up synthesis.
Key Skills
  • Oligonucleotide Synthesis
  • Automated Oligo Synthesizers
  • RNAi / RNA Therapeutics
  • Nucleic Acid Chemistry
  • HPLC Purification
  • Mass Spectrometry (LC-MS)
  • Oligonucleotide Characterization
  • Impurity Profiling & Troubleshooting
  • Organic Synthesis


If interested, please send your updated resume at hr@dawarconsulting.com/kavitha@dawarconsulting.com