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Next Generation Sequencing Jobs in California (NOW HIRING)

KMR Search Group

Principal Scientist I

Livermore, CA · On-site

Company is developing a novel, single molecule Next Generation Sequencing platform that aims to bring DNA and RNA sequencing-based diagnostic assays to patients everywhere. The Assays and Biomarkers ...

Talnt

Associate Scientist

Carlsbad, CA

$80K - $100K/hr

This role is ideal for a scientist with a strong background in molecular biology, genomics, and next-generation sequencing (NGS) who is passionate about developing cutting-edge genomic solutions. The ...

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Next Generation Sequencing information

See California salary details

$28.1K

$65.4K

$114.5K

How much do next generation sequencing jobs pay per year?

As of Aug 18, 2026, the average yearly pay for next generation sequencing in California is $65,401.00, according to ZipRecruiter salary data. Most workers in this role earn between $38,500.00 and $81,900.00 per year, depending on experience, location, and employer.

What is next generation sequencing?

A Next Generation Sequencing (NGS) job involves working with advanced DNA and RNA sequencing technologies to analyze genetic material. Professionals in this field may design experiments, prepare biological samples, operate sequencing instruments, and interpret genomic data. Roles can vary from research scientists and bioinformaticians to lab technicians and data analysts. NGS is widely used in medicine, agriculture, and biotechnology for applications such as disease research, personalized medicine, and evolutionary studies. Strong skills in molecular biology, computational analysis, and data interpretation are typically required.

What does someone working in next generation sequencing do?

Professionals in Next Generation Sequencing typically spend their days preparing and processing biological samples, operating sequencing instruments, and analyzing genomic data. They are responsible for troubleshooting technical issues, maintaining laboratory equipment, and ensuring quality control throughout the sequencing workflow. Collaboration with cross-functional teams—such as bioinformaticians, clinicians, and research scientists—is common to interpret sequencing results and contribute to project goals. This role also involves detailed record-keeping and adherence to regulatory or laboratory standards, making organization and communication important aspects of the job.

What are the key skills and qualifications needed to thrive in next generation sequencing?

To excel in a Next Generation Sequencing (NGS) role, you need a strong background in molecular biology, genomics, and data analysis, often supported by a degree in a life science field. Proficiency with NGS platforms (such as Illumina or Oxford Nanopore), laboratory automation tools, and bioinformatics software is highly valued, alongside relevant certifications in genomics or molecular diagnostics. Strong problem-solving abilities, attention to detail, and effective teamwork and communication skills set successful professionals apart. These competencies ensure high-quality sequencing results, efficient workflow, and productive collaboration in fast-paced research or clinical environments.

What are the most commonly searched types of Next Generation Sequencing jobs in California?

The most popular types of Next Generation Sequencing jobs in California are:

What are popular job titles related to Next Generation Sequencing jobs in California?

For Next Generation Sequencing jobs in California, the most frequently searched job titles are:

What job categories do people searching Next Generation Sequencing jobs in California look for?

The top searched job categories for Next Generation Sequencing jobs in California are:

What cities in California are hiring for Next Generation Sequencing jobs?

Cities in California with the most Next Generation Sequencing job openings:

Next Generation Sequencing jobs near you
Infographic showing various Next Generation Sequencing job openings in California as of August 2026, with employment types broken down into 84% Full Time, 10% Part Time, and 6% Contract. Highlights an 92% Physical, 3% Hybrid, and 5% Remote job distribution, with an average salary of $65,401 per year, or $31.4 per hour.

Principal Mechanical Engineer, Next-Gen Sequencing Systems, Research & Early Development

F. Hoffmann-La Roche Ltd

Santa Clara, CA • On-site

$110K - $205K/yr

Full-time

Posted 27 days ago

Job description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.
The Position
At Roche, we are working to make next-generation sequencing simple and accessible enough for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow.
This hands-on role focuses on solving mechanical challenges for our next-generation platforms. You will be responsible for conceptualizing, designing, building, and testing electro-mechanical, pneumatic, thermal, fluidic, and consumable solutions that ensure system performance, reliability, and longevity. As a technical authority, you will drive innovation and define solutions for novel DNA sequencing and automation challenges.
The Opportunity & Responsibilities:
  • You will drive the research and development of various sub-systems, encompassing electro-mechanical, pneumatic, thermal, fluidic, and consumable technologies.
  • You will collaborate with cross-functional teams to define and manage critical technical interfaces.
  • You will own sub-systems through verification, integration, and troubleshooting, working closely with System Integration engineers.
  • You will lead cross-functional design reviews to drive alignment and resolve technical trade-offs.
  • You will manage design deliverable timelines and contribute to overall project planning.
  • You will create and maintain comprehensive design documentation.
  • You will contribute to technical strategy, providing data-driven recommendations on architecture and technology.
  • You will present progress, data, and design trade-offs to stakeholders, clearly articulating the impact of engineering decisions.

This is an onsite position based in Santa Clara, CA.
Relocation benefits are not offered for this role.
Who You Are:
(Required)
  • You have a degree in Mechanical Engineering, or a closely related discipline, with relevant industry experience (minimum 7+ years for a Bachelor's, 4+ years for a Master's, or 3+ years for a PhD).
  • You have demonstrated hands-on experience designing, developing, and testing complex electro-mechanical, pneumatic, thermal, or fluidic assemblies, preferably for life science or diagnostic instrumentation.
  • You are highly proficient in SolidWorks for detailed design and the creation of manufacturing drawings.
  • You have demonstrated experience designing components for a variety of manufacturing processes (e.g., machining, sheet metal, injection molding, 3D printing).
  • You have demonstrated problem-solving skills; ability to troubleshoot complex hardware, software, and chemistry interfaces.
  • You are proficient with machine shop tools, measurement equipment, and rapid prototyping (e.g., CNC mills/lathes, laser cutters, 3D printers).
  • You have experience solving unique or unpredictable problems that might have an impact on the goals and objectives as set by the organization

Preferred:
  • You have an advanced degree in Mechanical Engineer, or a closely related discipline
  • You have a high level of proficiency with Python for device control and data acquisition.
  • You have experience with simulation tools (CFD, FEA) to guide design decisions.
  • You have experience developing next-generation sequencing (NGS) or genomics instrumentation.
  • You have strong interpersonal skills; ability to explain technical concepts to non-experts and thrive in ambiguous environments.
  • You have excellent organizational skills with the ability to manage multiple projects efficiently.

The expected salary range for this position based on the primary location Santa Clara, CA is $110,400 - $205,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.
This position also qualifies for the benefits detailed at the link provided below.
Benefits
#RMS72026
Who we are
A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.
Let's build a healthier future, together.
Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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