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Microphysiological Jobs (NOW HIRING)

Duke University

Postdoctoral Associate

Durham, NC

We seek a highly motivated individual with a background in neuroscience who can leverage techniques including advanced genomics, microphysiological cell culture system, and animal models. The team is ...

Precise Systems

In-Vitro Toxicologist

Aberdeen, MD · On-site

$76K - $86K/yr

Experience with several advanced laboratory cellular biology and tissue culture techniques, to include but not limited to, receptor-based screens, microphysiological systems, stem cell ...

MRIGlobal

Post-Doctoral Research Fellow

Kansas City, MO · On-site

$64K - $80K/yr

Experience developing advanced in vitro systems, including microphysiological systems, bioreactors, perfusion platforms, or 3D tissue models. * Expertise in reproductive biology, germ cell biology ...

Duke University

Postdoctoral Associate

Durham, NC · On-site

We seek a highly motivated individual with a background in neuroscience who can leverage techniques including advanced genomics, microphysiological cell culture system, and animal models. The team is ...

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Microphysiological information

What are the key skills and qualifications needed to thrive as a Microphysiological Systems Scientist, and why are they important?

To thrive as a Microphysiological Systems Scientist, you need a strong background in cell biology, tissue engineering, and biomaterials, typically supported by an advanced degree in biological sciences or bioengineering. Familiarity with microfluidic device fabrication, imaging systems, and analytical software like MATLAB or ImageJ is often required. Creative problem-solving, attention to detail, and strong collaboration skills are crucial in this interdisciplinary field. These skills enable the design and analysis of complex biological models that advance drug discovery and biomedical research.

What are microphysiological systems?

Microphysiological systems, also known as organ-on-a-chip technologies, are advanced laboratory models that replicate the functions of human organs on a miniature scale. These systems use living cells arranged on micro-engineered platforms to mimic the structure and function of tissues and organs. They are used in biomedical research to study disease mechanisms, drug responses, and toxicity in a controlled environment, potentially reducing the need for animal testing. Microphysiological systems provide more accurate and human-relevant data compared to traditional cell cultures or animal models.

What is the difference between Microphysiological vs Cell Culture Technician?

AspectMicrophysiologicalCell Culture Technician
Required CredentialsTypically requires a degree in biology, biomedical engineering, or related fieldsOften requires a degree or certification in biology or laboratory techniques
Work EnvironmentResearch labs, biotech companies, pharmaceutical testing facilitiesLaboratories, research institutions, biotech companies
Industry UsageUsed in drug testing, disease modeling, tissue engineeringUsed in cell growth, maintenance, and preparation for experiments

Microphysiological roles focus on creating complex tissue models that mimic human organs, often requiring advanced technical skills. Cell Culture Technicians primarily handle cell growth and maintenance. While both roles involve laboratory work and biological expertise, Microphysiological positions typically demand more specialized knowledge in tissue engineering and organ-on-chip systems.

What are some common challenges faced by microphysiological system researchers, and how can new team members prepare for them?

Microphysiological system researchers often encounter challenges such as integrating complex biological and engineering concepts, troubleshooting device malfunctions, and ensuring reproducibility of experimental results. New team members can prepare by staying updated on the latest advances in organ-on-chip technologies, refining their problem-solving skills, and actively communicating with multidisciplinary colleagues. Participating in regular team meetings and collaborating closely with engineers, biologists, and data analysts will help address issues as they arise and foster a supportive research environment.
More about Microphysiological jobs
What cities are hiring for Microphysiological jobs? Cities with the most Microphysiological job openings:
What states have the most Microphysiological jobs? States with the most job openings for Microphysiological jobs include:
What job categories do people searching Microphysiological jobs look for? The top searched job categories for Microphysiological jobs are:
Microphysiological jobs near you
Infographic showing various Microphysiological job openings in the United States as of July 2026, with employment types broken down into 90% Full Time, 7% Part Time, and 3% Contract. Highlights an 100% Physical job distribution.
Senior Scientist / Principal Scientist, Complex in Vitro Systems

Senior Scientist / Principal Scientist, Complex in Vitro Systems

Genentech, Inc.

South San Francisco, CA • On-site

Full-time

Posted 24 days ago

Genentech rating

8.8

Company rating: 8.8 out of 10

Based on 22 frontline employees who took The Breakroom Quiz

10th of 74 rated pharmaceutical

Job description

We advance science so that we all have more time with the people we love.
The Position:
The Complex in Vitro Systems (CiS) Lab within the Department of Translational Safety is seeking a highly motivated Senior Scientist / Principal Scientist to develop, characterize, and qualify advanced complex in vitro models to support Genentech's mission of delivering safe and efficacious medicines. The CiS group partners closely with colleagues across Development Sciences, Translational Medicine, and Research to establish and implement innovative platforms that enable target assessment, lead optimization, and safety evaluation across a dynamic portfolio, novel modalities, and emerging therapeutic areas.
In this lab-based role, you will provide scientific and technical expertise to support the development and implementation of human iPSC-derived ocular complex in vitro models (CIVM) including retinal organoids, for drug development. Responsibilities include culturing and characterizing state-of-the-art ocular CIVM models, designing and executing model qualification and characterization studies (e.g., advanced imaging, transcriptomics, and functional and phenotypic assays), analyzing and interpreting complex datasets; and maintaining rigorous, high-quality documentation. The Scientist will be expected to share scientific insights across functional teams, contribute to cross-disciplinary collaborations, and support internal and external publication efforts.
This position is ideal for an experienced scientist passionate about advancing disease modeling and translational safety through innovative complex in vitro and stem cell based approaches. The successful candidate will excel in a dynamic, collaborative research environment, demonstrate exceptional problem-solving skills, and effectively communicate across scientific disciplines to contribute to the development of cutting-edge ocular disease models and help shape the future of ocular drug discovery and development.
The Opportunity:
  • Establishing and implementing innovative in vitro ocular model systems including iPSC-derived retinal organoids and integrated retinal organoid retinal pigment epithelium (RPE) co-culture platforms to support disease modeling, mechanistic studies, and ocular risk assessment.
  • Designing and executing experiments to characterize retinal models, including evaluation of cell viability, morphology, photoreceptor health, and RPE barrier integrity and function, using techniques such as cytotoxicity assays, confocal and high-content imaging, transepithelial resistance/permeability assays, and transcriptomic and proteomic analyses.
  • Collaborating closely with cross-functional teams within and outside gRED to align ophtha complex model building with therapeutic strategies and program needs.
  • Analyzing, interpreting, and clearly communicating study results to collaborators and stakeholders, and contributing to internal and external scientific presentations as appropriate.
  • Maintaining comprehensive electronic documentation in accordance with departmental Standard Operating Procedures (SOPs) and contributing to study reports, safety assessments, and final deliverables.

Who You Are:
  • PhD degree in biology, bioengineering, biomedical engineering, pharmacology, or a related field with hypothesis-driven research in industry or academia; compensation and title commensurate with experience
  • For Senior Scientist (0-4 years) and for Principal Scientist (5+ years) of post-PhD experience in pharmaceutical, biotechnology, academia, or research organizations, with a strong focus on complex in vitro ocular systems.
  • Expertise in developing, qualifying, and applying 3D ocular tissue models, retinal organoids, co-culture systems, and microphysiological or microfluidic platforms, to support drug discovery and translational research is a strong plus.
  • Proficiency with quantitative and qualitative characterization techniques such as qRT-PCR, scRNA-seq, proteomics, immunofluorescence and confocal microscopy, live-cell and time-lapse imaging, high-content imaging/screening, and analysis of data generated from these assays.
  • A collaborative, team-oriented scientist who prioritizes shared objectives and communicates effectively across disciplines, with a strong work ethic grounded in scientific rigor, attention to detail, and a commitment to excellence.
  • Strong scholastic record with demonstrated independent thought, creativity, and technical proficiency in the relevant discipline, as evidenced by co-authored publications.
  • Strong organizational and communication skills are necessary; experience writing detailed SOPs.
  • Ability to analyze, integrate, and clearly communicate/present data to colleagues is required.

Preferred Qualifications:
  • Experience with stem cell based systems and ophthalmology background is a strong plus. Additional desirable skill sets include cell engineering, application of design of experiments (DOE) methodologies, and computational data analysis and/or programming:compensation and title commensurate with experience

The expected salary range for this position based on the primary location of South San Francisco, California is $120,700- $224,100 (Senior Scientist) and $141,500- $262,900 (Principal Scientist) Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this job posting.
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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

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About Genentech

Sourced by ZipRecruiter

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Industry

Scientific research and development services

Company size

10,000+ Employees

Headquarters location

South San Francisco, CA, US

Year founded

1976

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