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Microphysiological Jobs (NOW HIRING)

Johns Hopkins University

Postdoctoral Fellowship

Baltimore, MD · On-site

$48K - $66K/yr

This role focuses on developing cutting-edge platforms and integrated devices for biosensing, microphysiological systems, microrobotics and biomedical engineering. Key Responsibilities * Design and ...

Draper

Sr. Intestinal Tissue Engineer

Cambridge, MA · On-site

$114K - $156K/yr

Develop, optimize, and characterize intestine microphysiological (MPS) and organ-on-chip models for toxicity, permeability, and disease-state studies * Apply cell biology, developmental biology, and ...

Draper

Sr. Intestinal Tissue Engineer

Cambridge, MA · On-site

$114K - $156K/yr

Develop, optimize, and characterize intestine microphysiological (MPS) and organ-on-chip models for toxicity, permeability, and diseasestate studies * Apply cell biology, developmental biology, and ...

Johns Hopkins University

Postdoctoral Fellow

Baltimore, MD · On-site

$48K - $66K/yr

... Microphysiological Systems (MPS). Application Instructions * How to apply (Interfolio): Submit (i) latest CV, (ii) cover letter with a description of research background and interests, and (iii) ...

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Microphysiological information

What are the key skills and qualifications needed to thrive as a microphysiological systems scientist, and why are they important?

To thrive as a Microphysiological Systems Scientist, you need a strong background in cell biology, tissue engineering, and biomaterials, typically supported by an advanced degree in biological sciences or bioengineering. Familiarity with microfluidic device fabrication, imaging systems, and analytical software like MATLAB or ImageJ is often required. Creative problem-solving, attention to detail, and strong collaboration skills are crucial in this interdisciplinary field. These skills enable the design and analysis of complex biological models that advance drug discovery and biomedical research.

What is a microphysiological system?

Microphysiological systems, also known as organ-on-a-chip technologies, are advanced laboratory models that replicate the functions of human organs on a miniature scale. These systems use living cells arranged on micro-engineered platforms to mimic the structure and function of tissues and organs. They are used in biomedical research to study disease mechanisms, drug responses, and toxicity in a controlled environment, potentially reducing the need for animal testing. Microphysiological systems provide more accurate and human-relevant data compared to traditional cell cultures or animal models.

What is the difference between Microphysiological vs Cell Culture Technician?

AspectMicrophysiologicalCell Culture Technician
Required CredentialsTypically requires a degree in biology, biomedical engineering, or related fieldsOften requires a degree or certification in biology or laboratory techniques
Work EnvironmentResearch labs, biotech companies, pharmaceutical testing facilitiesLaboratories, research institutions, biotech companies
Industry UsageUsed in drug testing, disease modeling, tissue engineeringUsed in cell growth, maintenance, and preparation for experiments

Microphysiological roles focus on creating complex tissue models that mimic human organs, often requiring advanced technical skills. Cell Culture Technicians primarily handle cell growth and maintenance. While both roles involve laboratory work and biological expertise, Microphysiological positions typically demand more specialized knowledge in tissue engineering and organ-on-chip systems.

What are common challenges faced by microphysiological system researchers, and how can new team members prepare for them?

Microphysiological system researchers often encounter challenges such as integrating complex biological and engineering concepts, troubleshooting device malfunctions, and ensuring reproducibility of experimental results. New team members can prepare by staying updated on the latest advances in organ-on-chip technologies, refining their problem-solving skills, and actively communicating with multidisciplinary colleagues. Participating in regular team meetings and collaborating closely with engineers, biologists, and data analysts will help address issues as they arise and foster a supportive research environment.
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Infographic showing various Microphysiological job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution.

Post Doctoral.Post Doctoral.Associate

University of Pittsburgh

Pittsburgh, PA

$47K - $64K/yr

Full-time

Re-posted 11 days ago

Job description

The Organ Pathobiology and Therapeutics Institute (OPTIn) is searching for a Postdoctoral Associate to play a significant role in our New Approach Methodologies (NAMs) program utilizing our biomimetic human liver acinus microphysiological system (LAMPS) platform.  We use both primary human cells and iPSC-derived cells for evaluating metabolic dysfunction-associated steatotic liver disease (MASLD) progression, identifying disease-relevant biomarkers, and testing of candidates as well as a precision medicine platform for the development of patient digital twins and patient biomimetic twins.  We are one of four Translational Centers for MPS (TraCe-MPS) established in collaboration with the National Center for Advancing Translational Sciences (NCATS) and the FDA, with the goal of qualifying our liver MPS platforms as drug development tools (DDTs) for various specific contexts of use.  A key focus of the current position is the detection of low-level, subclinical effects in a human based system using real-time fixed endpoint, secretome-based, and image-based readouts to identify early activation of toxicity pathways.  The incumbent will primarily participate within the TraCe-MPS group for the qualification of the LAMPS platform as a DDT with the FDA to aid in the determination of drug candidate dosing in patients with MASLD. Great talent in complex, multi-cell-based experimentation, knowledge of liver physiology, experience identifying toxicity signals via phenotype and molecular level assays and high content imaging experience is required.   Toxicologists, pharmacologists or cell biologists and/or biomedical engineers with experience in the design and application of liver MPS systems are also strongly encouraged to apply.  This is an excellent introductory level opportunity for a scientist to join a highly collaborative team of bio-engineers, cell and molecular biologists, computational biologists, pharmacologists, and clinician-scientists to apply our MPS models of disease to drug discovery.

Experience and Training

        Ph.D. in toxicology, pharmacology, physiology, cell biology, biophysics, biomedical engineering, or related field.

        Strong cell-based research experience; previous experience with liver MPS model systems or co-culture systems is highly valued.

        Working knowledge of toxicology and pharmacology is greatly desired.

        Experience in liver cell and organ physiology, cell and molecular biology and fluorescence imaging and quantification is desired.

        Experience with primary (patient isolated) human cells and iPSCs a plus.

Position Responsibilities

        Perform studies for the qualification of the LAMPS platform as a DDT.

        Conduct and manage independent research projects from experimental design through implementation and analysis.  Present results in seminars and publications.

        Prepare and draft various research documents including manuscripts, proposals, and grant applications.

        Collaborate with the liver microphysiological systems team and clinician-scientists at Pitt.

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