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Manufacturing Execution System Jobs in Indiana (NOW HIRING)

... Execution Support client engagements with strong customer-service orientation Perform system ... manufacturing execution systems is highly desirable Data integrity assessment/remediation ...

System Configuration & Integration * Configure and support SAP S/4HANA Manufacturing processes, including: * Production Planning (MPS, MRP, capacity planning) * Production execution and shop floor ...

System Configuration & Integration * Configure and support SAP S/4HANA Manufacturing processes, including: * Production Planning (MPS, MRP, capacity planning) * Production execution and shop floor ...

Experience with manufacturing execution system platforms, including Opcenter, Apriso, AVEVA, or FactoryTalk * Experience with ISA-95 or ISA-88 frameworks * Experience supporting Industry 4.0 ...

Support development and implementation activities for manufacturing execution systems and communicate progress to leadership * Support process integration, root cause analysis, corrective action ...

... manufacturing execution system (MES) solutions. You'll spend time on the plant floor and in stakeholder interviews uncovering how a client's operations really work, then translate what you learn into ...

Serve as the site's subject matter expert and primary user for OHCMS (One Howmet Casting Manufacturing System), Howmet's internal manufacturing execution and lot traceability system, act as backup to ...

Showing results 41-60

Manufacturing Execution System information

See Indiana salary details

$38.5K

$104.9K

$150.8K

How much do manufacturing execution system jobs pay per year?

As of Aug 22, 2026, the average yearly pay for manufacturing execution system in Indiana is $104,878.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,900.00 and $135,600.00 per year, depending on experience, location, and employer.

What is a manufacturing execution system?

A Manufacturing Execution System (MES) job involves overseeing and managing software solutions that monitor, control, and optimize manufacturing processes on the shop floor. Professionals in this role ensure seamless data flow between production equipment, operators, and enterprise systems to improve efficiency, quality, and compliance. Responsibilities often include system implementation, configuration, troubleshooting, and continuous improvement initiatives. MES roles are crucial in industries like automotive, pharmaceuticals, and electronics, where real-time production tracking is essential.

What does a manufacturing execution system do?

Professionals in an MES role are responsible for configuring, monitoring, and optimizing the software systems that track and control manufacturing processes on the production floor. Daily tasks often include troubleshooting system issues, analyzing production data to support decision-making, and collaborating closely with production, quality, and IT teams to ensure seamless workflow integration. They may also be involved in implementing new system features, maintaining system documentation, and training end-users on MES functionalities. This role requires a proactive approach to problem-solving and strong collaboration to ensure production efficiency and product quality.

What are the key skills and qualifications needed to thrive in the manufacturing execution system position, and why are they important?

To thrive in a Manufacturing Execution System (MES) role, you need a solid understanding of manufacturing processes, strong analytical skills, and often a degree in engineering, information technology, or a related field. Familiarity with MES platforms (such as Siemens Opcenter, Rockwell FactoryTalk, or GE Proficy), database management, and relevant certifications are commonly required. Effective communication, problem-solving, and project management abilities are crucial soft skills for success in this position. These competencies ensure seamless integration of technology on the production floor, enabling efficient operations and quick response to production challenges.

What are popular job titles related to Manufacturing Execution System jobs in Indiana?

For Manufacturing Execution System jobs in Indiana, the most frequently searched job titles are:

What job categories do people searching Manufacturing Execution System jobs in Indiana look for?

The top searched job categories for Manufacturing Execution System jobs in Indiana are:

Infographic showing various Manufacturing Execution System job openings in Indiana as of August 2026, with employment types broken down into 1% As Needed, 82% Full Time, 14% Part Time, and 3% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $104,878 per year, or $50.4 per hour.

Principal Automation Integration Engineer - API Network

Initial Therapeutics, Inc.

Indianapolis, IN • On-site

$66 - $171.60/hr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 4 days ago


Job description

Organization Overview

Lilly is at a critical juncture as we tool up to realize the potential of our product pipeline. We are building new processing capabilities around the world, and emphasizing emerging, innovative technologies, such as continuous processing, biotech platforms, and advanced data and control systems. Additionally, we are recapitalizing older assets and bringing the operational philosophies in line with current technologies. Lilly places a high value on fully automated manufacturing processes, as the quality and operational benefits are baseline expectations of new process design.

Position Description and Responsibilities

The Principal Automation Integration Engineer – API Network Integration will enable information and data flow between Manufacturing Science, Quality, Engineering, Supply Chain, and Operations by leveraging IT and Process Automation Technologies. This role will support innovation evaluation and application for Manufacturing Process Automation and IT Systems with a focus on data historians, advanced analytics, cyber security, and process optimization. The primary focus of the role will be to work with our Process Automation and IT systems to integrate data supporting major capital projects. The role will be focused on supporting sites and projects within the API Network. These systems include (but not limited too) process automation platforms, HMI/SCADA, Data Historians, Alarm/Event management, and Manufacturing Execution systems. A high level of experience in automation architecture and technology trends is desired, with additional expertise needed in the primary areas of process automation and control: safety systems, process control, motion control, cyber security, and batch control. This role can be paralleled to being an “in‑house system integrator” within the corporate engineering team. This role is a mid‑level engineering role which requires high learning agility and an interest and/or background in project management along with a technical understanding of automation system integration. There is an expectation of travel to other Lilly domestic and international locations, generally 20%, with periods of heavy travel during commissioning of projects with up to 80% travel or short‑term assignments to relocate to the project location.

Key Objectives/Deliverables
  • Work safely and continually look for improvements to both people and equipment safety.
  • Provide project management and technical leadership of central automation system platform delivery for major capital projects at new and existing Lilly Manufacturing sites.
  • Develop and maintain a fully integrated schedule, connecting key milestones from the various workstreams/systems within the automation integration scope.
  • System Integrator – Develop robust and innovative solutions enabling our manufacturing engineers to utilize data to drive improvement decisions, identify issues, and utilize advanced analytics.
  • Ensure overall automation integration system requirements are delivered and tested, and that timing/dependencies for this work is included in overall project schedule.
  • Escalate key issues or barriers through project leadership team to resolve.
  • Facilitate regularly scheduled system delivery meetings (coordination meetings with other workstreams, working sessions, and project status updates to leadership).
Basic Qualifications
  • Bachelor's degree in Engineering, Computer Science, Information Systems, or related technical discipline.
  • 3+ years of hands‑on experience in process automation engineering and data integration (e.g. data historians, data analytics, visualization, MES integration, enterprise level applications, and security).
  • Prior project management and technical leadership experience on large projects (preferably $2‑3M+).
  • Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F‑1 CPT, F‑1 OPT, F‑1 STEM OPT, J‑1, H‑1B, TN, O‑1, E‑3, H‑1B1, or L‑1 (https://careers.lilly.com/us/en/workplace-accommodation).
Additional Skills/Preferences
  • Knowledge of System Integration, Data Integration, Databases, enterprise systems, Process Automation Systems, Historian, and Manufacturing Execution Systems.
  • Core knowledge related to ISE S95 and S88 principles.
  • IT/Automation integration.
  • Demonstrated proficiency in project management.
  • Ability to work well with different cultures.
  • Experience in pharma or GMP industry.
  • Experience working with validated systems.
  • Expertise in Lilly’s preferred platforms, including Rockwell Automation, Emerson DeltaV, PMX/PharmaSuite, and Syncade.
  • Experience in OSI PI Data Historians.
Additional Information
  • Monday through Friday Day Shift of 7:30 am‑4:30 pm with some allowance for flex time.
  • Location: Indianapolis, IN.
  • Travel: Domestic and International travel required (generally 20%, heavy periods up to 80%).

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $66,000 - $171,600.

Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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