Manager Elisa Jobs (NOW HIRING)

Overview:

We are seeking a highly skilled Bioanalytical Scientist to lead the development, validation, and lifecycle management of analytical methods supporting drug development programs. This role will focus on oligonucleotide therapeutics and large molecule bioanalysis, supporting both nonclinical and clinical studies in a regulated environment.

• Design, optimize, and validate high-sensitivity analytical methods (e.g., LC-MS/MS, hybrid ELISA, qPCR) for oligonucleotide therapeutics (ONTs) and their metabolites
• Develop and validate ligand-binding assays (e.g., ELISA, MSD/ECL) to support pharmacokinetics (PK) and immunogenicity assessments (ADA, NAb) for large molecules
• Oversee the full lifecycle of bioanalytical assays, from early development through clinical phases and regulatory submission
• Analyze, interpret, and report complex bioanalytical data, including PK and immunogenicity results, to support ADME, DMPK, toxicology (TK), and PK/PD evaluations
• Collaborate with cross-functional teams to support in vitro and in vivo studies across discovery and development stages
• Ensure all bioanalytical activities comply with global regulatory guidelines, including ICH M10, and support IND and NDA submissions
• Partner with external vendors/CROs as needed to support study execution and data delivery

• Strong expertise in DMPK, immunogenicity, and PK assay development
• Experience in translational biology and bioanalytical method development
• Proficiency with analytical techniques including LC-MS/MS, ELISA/ECL, and qPCR
• Familiarity with oligonucleotide therapeutics (e.g., siRNA, conjugated ONTs) and tissue-based analysis

• PhD in Medicinal Chemistry, Analytical Chemistry, Biochemistry, or a related field
• 3–5 years of experience in analytical or bioanalytical laboratory settings, including study oversight and CRO management
• Demonstrated hands-on experience developing bioanalytical methods for oligonucleotides, including sample extraction from tissue and biological matrices
• Broad understanding of drug discovery and development, including in vitro/in vivo pharmacology, ADME, PK/PD, and translational research
• Strong knowledge of GLP/GCP regulations and ICH guidelines

Job Type & Location

This is a Contract position based out of Cambridge, MA.

The pay range for this position is $77.00 - $90.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:
• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)

This is a hybrid position in Cambridge,MA.

This position is anticipated to close on Jun 23, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.

San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.