Licensed practical nurse weekend jobs, or LPN weekend jobs, focus on performing practical nursing duties during the weekend. Your responsibilities can vary from job to job, but weekend nurses work on a Saturday-Sunday schedule. LPNs most frequently work in clinical settings in hospitals or health care facilities where they assist patients, read vital signs, set up and operate medical equipment, check patients’ conditions, perform essential medical tests, and obtain and update medical records. Weekend shift LPN positions also exist in assisted living facilities and the home healthcare industry.