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Light Sheet Microscopy Jobs (NOW HIRING)

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Light Sheet Microscopy information

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$14

$25

$34

How much do light sheet microscopy jobs pay per hour?

As of Jul 3, 2026, the average hourly pay for light sheet microscopy in the United States is $25.08, according to ZipRecruiter salary data. Most workers in this role earn between $20.91 and $29.33 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Light Sheet Microscopy Specialist, and why are they important?

To excel as a Light Sheet Microscopy Specialist, you need a strong background in biology, physics, or related sciences, with hands-on experience in advanced imaging techniques. Familiarity with specialized microscopy systems, image analysis software (such as Fiji/ImageJ), and possibly certifications in microscopy or laboratory techniques is highly beneficial. Attention to detail, problem-solving skills, and effective communication are crucial for troubleshooting, collaborating with researchers, and presenting findings. These competencies are essential for producing accurate imaging data and advancing research in biomedical and life sciences.

What is light sheet microscopy?

Light sheet microscopy is an advanced imaging technique that uses a thin sheet of light to illuminate a specimen from the side, allowing for rapid and gentle imaging of living tissues and large biological samples. This method minimizes photodamage and bleaching, making it ideal for long-term observation of live samples. Light sheet microscopy provides high-resolution, three-dimensional images, and is often used in developmental biology, neuroscience, and other fields requiring detailed visualization of complex biological structures.

What are some common challenges faced by professionals working with light sheet microscopy, and how can they be addressed?

Professionals using light sheet microscopy often encounter challenges such as sample preparation, optical alignment, and managing large datasets. Preparing samples that are both transparent and stable is crucial for achieving clear images, and this can require specialized clearing techniques. Proper alignment of the light sheet and detection objectives is essential for optimal imaging, often necessitating fine adjustments and calibration. Additionally, since light sheet microscopy generates extensive 3D data, managing and analyzing these large datasets can be demanding, making familiarity with specialized software and robust data storage solutions important. Collaborating closely with imaging specialists and data analysts within the team can help address these challenges efficiently.

What is the difference between Light Sheet Microscopy vs Microscopy Technician?

AspectLight Sheet MicroscopyMicroscopy Technician
Required CredentialsAdvanced degrees in biology, physics, or related fields; specialized training in microscopy techniquesAssociate or bachelor's degree in biology, chemistry, or related fields; technical training in microscopy
Work EnvironmentResearch labs, universities, biotech companies with advanced imaging equipmentLaboratories, hospitals, research institutions operating various microscopy systems
Industry UsageResearch and development, biological imaging, neuroscienceSample preparation, equipment maintenance, imaging operation

While Light Sheet Microscopy involves operating advanced imaging systems for high-resolution 3D imaging, Microscopy Technicians focus on maintaining and operating various microscopy equipment, including light microscopes. Both roles require technical skills, but Light Sheet Microscopy specialists typically have more specialized training and work on complex imaging projects.

More about Light Sheet Microscopy jobs
What cities are hiring for Light Sheet Microscopy jobs? Cities with the most Light Sheet Microscopy job openings:
What states have the most Light Sheet Microscopy jobs? States with the most job openings for Light Sheet Microscopy jobs include:
Infographic showing various Light Sheet Microscopy job openings in the United States as of June 2026, with employment types broken down into 1% As Needed, 98% Full Time, and 1% Temporary. Highlights an 98% Physical, and 2% Remote job distribution, with an average salary of $52,160 per year, or $25.1 per hour.
Postdoctoral Scholar - Biochemistry and Molecular Biology

Postdoctoral Scholar - Biochemistry and Molecular Biology

Penn State University

University Park, PA • On-site

Full-time

Posted 20 days ago


Penn State University rating

7.8

Company rating: 7.8 out of 10

Based on 103 frontline employees who took The Breakroom Quiz

197th of 544 rated colleges and universities


Job description

APPLICATION INSTRUCTIONS:
  • CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, apply internally through Workday.

  • CURRENT PENN STATE STUDENT (not employed previously at the university) and seeking employment with Penn State, please login to Workday to complete the student application process. Please do not apply here, apply internally through Workday.

  • If you are NOT a current employee or student, please click "Apply" and complete the application process for external applicants.

JOB DESCRIPTION AND POSITION REQUIREMENTS:
Postdoctoral Position working on single molecule imaging and gene regulation
One Postdoctoral Position is available in the lab of Dr. Manyu Du at The Pennsylvania State University.
The Du lab is interested in understanding how transcription machineries and regulatory DNA elements organize in 3D in the nucleus to regulate gene expression. We leverage single-molecule super-resolution imaging, advanced lattice light sheet microscopy and other state of the art biophysical approaches to study molecular mechanisms of transcription, genome organization and bio-molecular condensation in live cells. We are using mouse embryonic stem cells and mouse erythroid leukemia cells to investigate the dynamics and function of transcriptional condensates in health and disease. Other than imaging, we are also interested in biochemical, genetic and sequencing approaches to understand gene regulation. This position is open immediately and initially funded for two years.
YOUR TASKS:
Your role at the lab is to investigate the behavior of individual molecules and bio-molecular condensates in living cells. You will use and develop the imaging and computational methods that to visualize dynamic molecule clusters during gene expression to study the formation and function of these assemblies in gene regulation.
We want to recruit postdoc who is familiar with any of the following topics:
  • Prior background in studying bio-molecular condensates using a combination of biochemistry, fluorescence and quantitative modeling methods is highly desired.
  • Prior backgrounds in single-molecule imaging, as well as DNA/RNA imaging in live mammalian cells are highly desired.

YOUR QUALIFICATIONS:
We are looking for independent, creative and highly motivated post-doctoral scientists interested in exploring biophysical principles that regulate genomic processes.
  • Applicants should have a PhD in molecular biophysics, biochemistry or a related discipline.
  • The ability to work effectively in a team and possess good communication skills.

APPLICATION DEADLINE:
Please apply with your complete application documents (letter of motivation, curriculum vitae) including a statement of research interests via our Workday portal by June 1st, 2025. At the same time, please ask three of your referees to send recommendation letters to mxd451@psu.edu.
This is a term appointment initially funded for two years from date of hire with possibility of refunding.
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Employment with the University will require successful completion of background check(s) in accordance with University policies.
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