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Lexicon Pharmaceuticals Jobs (NOW HIRING)

CiTRUS Health Group

Scientific Director

Chicago, IL

Company Description Citrus Health Group is a unique partner to the pharmaceutical, biotechnology ... g., lexicon, scientific communication platform); 2) provide ongoing training and feedback to ...

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How much do lexicon pharmaceuticals jobs pay per year?

As of Aug 16, 2026, the average yearly pay for lexicon pharmaceuticals in the United States is $112,477.00, according to ZipRecruiter salary data. Most workers in this role earn between $95,500.00 and $131,000.00 per year, depending on experience, location, and employer.

What kinds of career advancement opportunities are available at Lexicon Pharmaceuticals?

Lexicon Pharmaceuticals offers a variety of career advancement pathways for employees, including opportunities to move into senior research, project management, regulatory affairs, or leadership positions. Many team members begin in research or technical roles and, through demonstrated expertise and initiative, transition into areas that match their interests and career goals. Professional development is supported through on-the-job training, mentorship programs, and access to conferences or continuing education. The company values talent development, so employees who proactively seek new challenges often find rewarding ways to grow their careers within the organization.

What are the key skills and qualifications needed to thrive in the Lexicon Pharmaceuticals position, and why are they important?

To thrive at Lexicon Pharmaceuticals, candidates typically need a solid background in life sciences, pharmaceutical research, or related fields, often supported by advanced degrees or relevant industry experience. Proficiency with laboratory technologies, drug development software, and compliance with FDA or other regulatory guidelines is highly valuable. Collaboration, problem-solving, and clear communication are essential for working effectively in multidisciplinary teams. These competencies enable employees to drive scientific innovation and ensure quality and regulatory compliance in a fast-paced pharmaceutical environment.

What is a Lexicon Pharmaceuticals job?

A Lexicon Pharmaceuticals job refers to a role within Lexicon Pharmaceuticals, a biopharmaceutical company focused on developing innovative medicines. Positions at Lexicon can range from research and development to clinical operations, regulatory affairs, and corporate roles. Employees work towards discovering and commercializing treatments for serious diseases, often targeting novel molecular mechanisms. The company offers opportunities for professionals in science, medicine, business, and manufacturing.

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Lexicon Pharmaceuticals jobs near you
Infographic showing various Lexicon Pharmaceuticals job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 1% As Needed, 82% Full Time, 14% Part Time, and 2% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $112,477 per year, or $54.1 per hour.

Manager, Finance and Accounting

LEXICON PHARMACEUTICALS

Spring, TX • On-site

Full-time

Re-posted 28 days ago

Job description

Lexicon is a biopharmaceutical company with a mission of pioneering medicines that transform patients’ lives. Through our unique approach to gene science based on Nobel Prize-winning technology, we are moving forward rapidly to bring innovative therapies to market. At Lexicon, our passion and dedication are driven by the patients for whom we work.

Lexicon employees are inspired by the idea that their work can improve patients' lives, and we know that our employees are essential to the success of our mission. Every day they bring their passion, talents, and dedication to an engaging environment where they are rewarded with opportunities to realize their potential. We are dedicated to making Lexicon a great place to work by providing employees with benefits, services, and programs as part of our total rewards package. Join our journey and be a part of our multitalented team and make a difference in patients’ lives!

We have offices in The Woodlands, Texas and Bridgewater, New Jersey.

We are seeking a highly motivated Manager of Finance and Accounting to join our team in The Woodlands, TX office. This role is hybrid.

Job Summary:

The Manager of Finance and Accounting will oversee the general ledger, ensuring accurate, timely financial accounting. This role will also support internal and external reporting, oversee key audit activities, and lead the SOX process, including control documentation and testing.

In addition, the Manager’s responsibilities will include preparing accruals for clinical and manufacturing activities and other high-risk areas, reviewing journal entries prepared by accounting staff, reconciling finished goods and other inventories, analyzing budget variances, and supporting R&D budgeting in partnership with department heads.

Specific responsibilities include:

  • Support the monthly accounting close by preparing certain entries (e.g. higher-risk clinical accruals, stock-based compensation entries, etc.) and reviewing other monthly journal entries and schedules prepared by staff/senior accountant(s).
  • Monitor progress against the close calendar.
  • Serve as point of contact with external auditors as part of the financial reporting and SOX audit processes. Coordinate and compile audit documentation as needed for external/SOX audits across key areas, including cash, prepaids, legal accruals, debt, allocations, etc.
  • Review/prepare monthly general ledger account reconciliations to ensure accuracy, completeness, and compliance with accounting standards.
  • Review daily cash activity and review associated journal entries to maintain accurate cash reporting.
  • Generate and prepare monthly financial reports, including the trial balance, variance reports, and flash reports, to support internal and external reporting needs.
  • Prepare select SEC disclosures as required
  • This role has supervisory responsibilities.
  • Completes ad hoc projects as needed.


Qualifications and Experience:

  • Bachelor’s degree in accounting, Finance or related field required
  • CPA Preferred
  • 4–6 years of public accounting experience or 5–8 years of industry experience in a public company
  • Proficient in GAAP; experienced in performing technical accounting research preferred
  • Experience with a large accounting system such as JDE, Oracle or SAP preferred
  • Experience with inventory accounting and/or clinical trial accruals preferred
  • Moderate Excel skills (VLOOKUP, pivot tables, filters, etc.) required
  • Excellent communication and interpersonal skills; demonstrated ability to work collaboratively across a matrixed organization
  • Resourceful and proactive with strong detail orientation, analytical skills, and ability to drive projects forward


For additional information about Lexicon and its programs, please visit www.lexpharma.com.

Lexicon is an Equal Opportunity Employer. We do not discriminate based on race, color, religion, sex, sexual orientation, gender identity, national origin, disability or status as a protected veteran.

Lexicon Pharmaceuticals, Inc. is a drug-free workplace. Candidates are required to pass a drug test, background check and verification of credentials before beginning employment.



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