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Lcms Operator Jobs (NOW HIRING)

Pioneer Data

LCMS Scientist

Spring House, PA · On-site

LCMS Scientist Duration: 8 months contract, extendable up to 24 Months Location: Spring House, PA ... Mass spectometry LC-MS experience Operating and validating robotic runs; monitoring performance ...

PathGroup

LCMS Application Specialist

Nashville, TN · On-site

Reviewing reports from laboratory equipment to ensure everything is operating in an efficient ... Review and monitoring of LCMS consumables and comparative inventory. NON-ESSENTIAL FUNCTIONS:

PathGroup

LCMS Application Specialist

Nashville, TN · On-site

Reviewing reports from laboratory equipment to ensure everything is operating in an efficient ... Review and monitoring of LCMS consumables and comparative inventory. NON-ESSENTIAL FUNCTIONS:

Actalent

LCMS Chemist

Hazelwood, MO · On-site

$40 - $55/hr

Draft, review, revise, and maintain controlled documents, including Standard Operating Procedures (SOPs), analytical methods, forms, work instructions, and laboratory records. * Ensure documentation ...

Actalent

LCMS Chemist

Hazelwood, MO · On-site

$40 - $55/hr

Draft, review, revise, and maintain controlled documents, including Standard Operating Procedures (SOPs), analytical methods, forms, work instructions, and laboratory records. * Ensure documentation ...

Actalent

LCMS Chemist

Hazelwood, MO · On-site

$40 - $55/hr

Draft, review, revise, and maintain controlled documents, including Standard Operating Procedures (SOPs), analytical methods, forms, work instructions, and laboratory records. * Ensure documentation ...

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Lcms Operator information

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$10

$23

$37

How much do lcms operator jobs pay per hour?

As of Aug 10, 2026, the average hourly pay for lcms operator in the United States is $23.04, according to ZipRecruiter salary data. Most workers in this role earn between $18.03 and $21.88 per hour, depending on experience, location, and employer.

What is an LCMS operator?

LCMS Operators are professionals who operate Liquid Chromatography-Mass Spectrometry (LC-MS) instruments, which are used to analyze chemical compounds in a variety of samples. They are responsible for preparing samples, running the LC-MS equipment, maintaining the instruments, and interpreting data to ensure accurate results. LCMS Operators often work in laboratories within industries such as pharmaceuticals, environmental science, food safety, and forensics. Their expertise is crucial for identifying and quantifying chemical substances in research and quality control processes.

What are some common challenges LCMS operators face when troubleshooting instrument performance issues?

LCMS Operators often encounter challenges such as inconsistent results, signal instability, or unexpected background noise during routine analyses. These issues may stem from factors like contaminated solvents, worn-out columns, or clogged ion sources. Successful troubleshooting typically involves methodically checking each component, maintaining detailed logs, and collaborating closely with analytical chemists and maintenance teams. Staying up to date with manufacturer protocols and regular preventive maintenance are key to minimizing downtime and ensuring reliable data generation.

What is the difference between Lcms Operator vs Analytical Chemist?

AspectLcms OperatorAnalytical Chemist
Required CredentialsAssociate degree or relevant certification, training in chromatographyBachelor's degree in chemistry or related field, often with advanced certifications
Work EnvironmentLaboratory setting, operating chromatography instrumentsLaboratory, research, and development environments, performing complex analyses
Employer & Industry UsagePharmaceutical, biotech, environmental testing labsPharmaceutical, chemical manufacturing, research institutions
Common Search & ComparisonOften compared for entry-level roles in labsMore research-focused, higher education requirements

The main difference between an Lcms Operator and an Analytical Chemist lies in their responsibilities and qualifications. Lcms Operators typically handle instrument operation and basic data collection, requiring less advanced education. Analytical Chemists perform complex analyses, interpret data, and often hold higher degrees. Both roles are vital in laboratory settings, but they differ in scope and expertise.

What are the key skills and qualifications needed to thrive as an LCMS operator?

To thrive as an LCMS Operator, you need a solid background in analytical chemistry, attention to detail, and experience with laboratory practices, often supported by a degree in chemistry or a related field. Familiarity with liquid chromatography-mass spectrometry (LC-MS) instruments, data analysis software, and relevant quality control protocols is essential. Strong problem-solving skills, organization, and effective communication help you troubleshoot issues and collaborate with team members. These skills and qualifications ensure accurate sample analysis, reliable data, and efficient laboratory operations.
More about Lcms Operator jobs
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Lcms Operator jobs near you
Infographic showing various Lcms Operator job openings in the United States as of August 2026, with employment types broken down into 70% Full Time, 20% Part Time, and 10% Contract. Highlights an 100% In-person job distribution, with an average salary of $47,930 per year, or $23 per hour.

LCMS Scientist

Pioneer Data

Spring House, PA • On-site

Contractor

Re-posted 8 days ago

Job description

Position Details:
Our client, a world-leading Pharmaceutical Company in Spring House, PA is currently looking for a LCMS Scientist to join their expanding team.
 
Job Title: LCMS Scientist
Duration: 8 months contract, extendable up to 24 Months
Location: Spring House, PA
 
Note:
The client has the right-to-hire you as a permanent employee at any time during or after the end of the contract.
You may participate in the company group medical insurance plan
 
Description:
Overview
Be a part of a team developing state-of-the-art automation systems for mass spectrometry applied to biotherapeutics cell line development.
This role will leverage and develop the next phase of automation development in mass spectrometry supporting the Cell Engineering and Analytical Sciences group.
The role blends hands-on robotic operations, sample preparation, method development, and data analysis.
 
Notes:
Role is onsite 100% in Spring House, PA
Role is for 1 year at this time, regular business hours, NO TRAVEL
Bachelors degree is required
Mass spectometry required
LC-MS and sample prep required
Analyzing peptide mapping experience
Must have general lab skills
Will do programming, automation, but mass spectometry is required
Must have a willingness to learn and must be capable of learning
Will be managing samples D2D on mass spectometry
Experience with electronic lab notebooks
Must have Excel experience
Experience with Python, JavaScript, R
Must have a little industry experience
Top 2 Skills:
Mass spectometry
LC-MS experience

Job Description
Operating and validating robotic runs; monitoring performance, documenting deviations, and driving corrective action.
Develop and implement mass spectrometry assays to optimize protein expression levels, protein quality, and quantitation of biotherapeutics. Ensure accuracy and success of MS experiments through expertise in sample preparation.
Deploying, optimizing, maintaining, and continuously improving high-throughput workflows using liquid-handling robots and integrated automation workcells.
Analyze antibodies using peptide mapping, intact mass analysis, native mass spectrometry, and acoustic ejection mass spectrometry.
Troubleshooting instrumentation by coordinating with internal subject matter experts and external vendors to perform root cause analysis based on detailed scientific and technical investigations
Prepare and present scientific findings and recommendations to internal customers, project teams, and senior management.
Qualifications
Creative, independent problem‑solver with strong attention to detail and the ability to plan, prioritize, and deliver in a fast‑paced environment.
A minimum of a B.S. in Biology, Chemistry, Computer Science, Engineering, or a related field is requited. An advanced degree is preferred.
Strong organizational, time management, and interpersonal skills (both written and oral), and a commitment in close collaboration with scientists, vendors, and end users across seniority levels.
Previous hands on experience with executing protocols, pipetting and protein sample handling skills.
Experience with operating liquid handling systems (e.g., Hamilton, Tecan, Beckman) and/or basic programming experience (Python, JavaScript, R, C++/C#).
Hands on experience with LC-MS and associated sample preparation.